Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anna M Dowbaj"'
Autor:
Jianjiang Hu, Xavier Serra‐Picamal, Gert‐Jan Bakker, Marleen Van Troys, Sabina Winograd‐Katz, Nil Ege, Xiaowei Gong, Yuliia Didan, Inna Grosheva, Omer Polansky, Karima Bakkali, Evelien Van Hamme, Merijn van Erp, Manon Vullings, Felix Weiss, Jarama Clucas, Anna M Dowbaj, Erik Sahai, Christophe Ampe, Benjamin Geiger, Peter Friedl, Matteo Bottai, Staffan Strömblad
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 6, Pp 1-15 (2023)
Abstract High‐content image‐based cell phenotyping provides fundamental insights into a broad variety of life science disciplines. Striving for accurate conclusions and meaningful impact demands high reproducibility standards, with particular rel
Externí odkaz:
https://doaj.org/article/732ee8bfa8294913a63eccb0f9aa6998
Autor:
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The E3 ubiquitin ligases RNF43/ZNRF3 are often mutated in cancer but their precise contribution to liver disease is unknown. Here, the authors show that RNF43/ZNRF3 alterations predispose to liver cancer by controlling the differentiation and lipid m
Externí odkaz:
https://doaj.org/article/b340f59562d343c38a3ffe78a2def2d3
Autor:
Jianjiang Hu, Xavier Serra-Picamal, Gert-Jan Bakker, Marleen Van Troys, Sabina Winograd-katz, Nil Ege, Xiaowei Gong, Yuliia Didan, Inna Grosheva, Omer Polansky, Karima Bakkali, Evelien Van Hamme, Merijn Van Erp, Manon Vullings, Felix Weiss, Jarama Clucas, Anna M. Dowbaj, Erik Sahai, Christophe Ampe, Benjamin Geiger, Peter Friedl, Matteo Bottai, Staffan Strömblad
High-content image-based cell phenotyping provides fundamental insights in a broad variety of life science areas. Striving for accurate conclusions and meaningful impact demands high reproducibility standards, even more importantly with the advent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13a169c6417efed2c58105be7f2b1482
https://doi.org/10.1101/2022.11.18.516878
https://doi.org/10.1101/2022.11.18.516878
Autor:
Zixuan Zhao, Xinyi Chen, Anna M. Dowbaj, Aleksandra Sljukic, Kaitlin Bratlie, Luda Lin, Eliza Li Shan Fong, Gowri Manohari Balachander, Zhaowei Chen, Alice Soragni, Meritxell Huch, Yi Arial Zeng, Qun Wang, Hanry Yu
Publikováno v:
Nat Rev Methods Primers
Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd49d8edcc406acf45c16f758bae97fa
https://europepmc.org/articles/PMC10270325/
https://europepmc.org/articles/PMC10270325/
Autor:
Neil C. Henderson, Richard Butler, Clare Pacini, Timo N Kohler, Ross Dobie, Meritxell Huch, Bernhard Strauss, Anna M. Dowbaj, John R. Wilson-Kanamori, Olga Sarlidou, Florian Hollfelder, Lucía Cordero-Espinoza, Palle Serup
In the homeostatic liver, ductal cells intermingle with a microenvironment of endothelial and mesenchymal cells to form the functional unit of the portal tract. Ductal cells proliferate rarely in homeostasis but do so transiently after tissue injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adeab6ee90ca48402638725d013b12bd
https://doi.org/10.1101/2020.09.21.306258
https://doi.org/10.1101/2020.09.21.306258
Autor:
Anna M Dowbaj, Reuben D. O'Dea, Alessandro Ciccarelli, Erik Sahai, Daniel E Williamson, Klaus M. Hahn, Marco Montagner, John R. King, Todd Fallesen, Robert P. Jenkins, John M. Heddleston
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The shuttling of transcription factors and transcriptional regulators into and out of the nucleus is central to the regulation of many biological processes. Here we describe a new method for studying the rates of nuclear entry and exit of transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412ddf40bfb080ead213c6551f2d554e
https://pubmed.ncbi.nlm.nih.gov/34060624
https://pubmed.ncbi.nlm.nih.gov/34060624
Autor:
Robert P. Jenkins, Erik Sahai, Todd Fallesen, Marco Montagner, John M. Heddleston, Klaus M. Hahn, Alessandro Ciccarelli, Anna M Dowbaj
The shuttling of transcription factors and transcriptional regulators in and out of the nucleus is central to the regulation of many biological processes. Here we describe a new method for studying the rates of nuclear entry and exit of transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73af25f28ffb7fe5c27626f46b987665
https://doi.org/10.1101/2020.06.08.140228
https://doi.org/10.1101/2020.06.08.140228
SummaryThe transcriptional regulator YAP1 is critical for the pathological activation of fibroblasts. In normal fibroblasts YAP1 is predominantly located in the cytoplasm, while in activated cancer-associated fibroblasts it exhibits nuclear localizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6c2fe0360a032215282d1e1970c1fc
Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export
Autor:
Erik Sahai, Charles T. Foster, Ming Jiang, Michael Howell, Robert P. Jenkins, Anna M Dowbaj, Nil Ege, Steven Hooper
Publikováno v:
Cell Systems
Summary The transcriptional regulator YAP1 is critical for the pathological activation of fibroblasts. In normal fibroblasts, YAP1 is located in the cytoplasm, while in activated cancer-associated fibroblasts, it is nuclear and promotes the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821b8b0b2c9bd3e35b88b1938fca28f2
https://pubmed.ncbi.nlm.nih.gov/29909276
https://pubmed.ncbi.nlm.nih.gov/29909276
Autor:
Palle Serup, John R. Wilson-Kanamori, Nicole Prior, Richard Butler, Anna M. Dowbaj, Neil C. Henderson, Nuno P. Martins, Clare Pacini, Timo N Kohler, Olga Sarlidou, Florian Jug, Florian Hollfelder, German Belenguer, Lucía Cordero-Espinoza, Ross Dobie, Bernhard Strauss, Meritxell Huch
Publikováno v:
Cell Stem Cell
Cordero-Espinoza, L, Dowbaj, A M, Kohler, T N, Strauss, B, Sarlidou, O, Belenguer, G, Pacini, C, Martins, N P, Dobie, R, Wilson-Kanamori, J R, Butler, R, Prior, N, Serup, P, Jug, F, Henderson, N C, Hollfelder, F & Huch, M 2021, ' Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation ', Cell Stem Cell, vol. 28, no. 11, pp. 1907-1921.e8 . https://doi.org/10.1016/j.stem.2021.07.002
Cordero-Espinoza, L, Dowbaj, A M, Kohler, T N, Strauss, B, Sarlidou, O, Belenguer, G, Pacini, C, Martins, N P, Dobie, R, Wilson-Kanamori, J R, Butler, R, Prior, N, Serup, P, Jug, F, Henderson, N C, Hollfelder, F & Huch, M 2021, ' Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation ', Cell Stem Cell, vol. 28, no. 11, pp. 1907-1921.e8 . https://doi.org/10.1016/j.stem.2021.07.002
Summary In the liver, ductal cells rarely proliferate during homeostasis but do so transiently after tissue injury. These cells can be expanded as organoids that recapitulate several of the cell-autonomous mechanisms of regeneration but lack the stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a908eaacc178873a58036a2cdcd426