Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anna M, Westermark"'
Autor:
Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden
Publikováno v:
eLife, Vol 9 (2020)
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolit
Externí odkaz:
https://doaj.org/article/d77eaf4877714df6a00d2b9f769cb0f8
Autor:
Kiera M. Sapp, Evan C. Lien, Allison N. Lau, Zhaoqi Li, Matthew G. Vander Heiden, Anna M. Westermark, Yin Zhang, Chen Yuan, Brian M. Wolpin
Publikováno v:
Nature
Dietary interventions can change metabolite levels in the tumour microenvironment, which might then affect cancer cell metabolism to alter tumour growth1–5. Although caloric restriction (CR) and a ketogenic diet (KD) are often thought to limit tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034a344f9f9255a46b3367455c764d70
https://doi.org/10.1038/s41586-021-04049-2
https://doi.org/10.1038/s41586-021-04049-2
Autor:
Jiang Chen, Anna M. Westermark, Lewis C. Cantley, Rakesh K. Jain, Brendan Prideaux, John M. Asara, Clary B. Clish, David P. Kodack, Neal I. Lindeman, Christopher W. Ng, Gino B. Ferraro, Ivy X. Chen, Costas A. Lyssiotis, Keene L. Abbott, Ahmed Ali, Jens Nielsen, Zohreh Amoozgar, Dai Fukumura, Raphael Ferreira, Dan G. Duda, Mark Duquette, David E. Housman, Jessica M. Possada, Véronique Dartois, Kamila Naxerova, Shawn M. Davidson, Xin Jin, Matthew G. Vander Heiden, Sylvie Roberge, Todd R. Golub, Amy Deik, Christopher R. Chin, Divya Bezwada, Elena F. Brachtel, Alba Luengo, Landry Blanc
Publikováno v:
Nature Cancer. 2:414-428
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the brain microenvironment contributes to this therapy resistance. Nutrient availability c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bfcc7374f8acf16821817f67010000
https://doi.org/10.1038/s43018-021-00183-y
https://doi.org/10.1038/s43018-021-00183-y
Autor:
Zhaoqi Li, Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine, Evan C. Lien, Aaron M. Hosios, Keene L. Abbott, Justine C. Rutter, Anna M. Westermark, Elizabeth F. Gorodetsky, Lucas B. Sullivan, Matthew G. Vander Heiden, Dennis Vitkup
Publikováno v:
Nat Metab
Production of oxidized biomass, which requires regeneration of the cofactor NAD+, can be a proliferation bottleneck that is influenced by environmental conditions. However, a comprehensive quantitative understanding of metabolic processes that may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754ddc49204415185a466d4ae8b80af3
https://europepmc.org/articles/PMC10305743/
https://europepmc.org/articles/PMC10305743/
Autor:
Zhaoqi, Li, Brian W, Ji, Purushottam D, Dixit, Konstantine, Tchourine, Evan C, Lien, Aaron M, Hosios, Keene L, Abbott, Justine C, Rutter, Anna M, Westermark, Elizabeth F, Gorodetsky, Lucas B, Sullivan, Matthew G, Vander Heiden, Dennis, Vitkup
Publikováno v:
Nature metabolism. 4(6)
Production of oxidized biomass, which requires regeneration of the cofactor NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc38cab45bd72b57b343427d022623b4
https://pubmed.ncbi.nlm.nih.gov/35739398
https://pubmed.ncbi.nlm.nih.gov/35739398
Autor:
David A. Tuveson, Nicholas J Matheson, Giulia Biffi, Evan C. Lien, Alicia M. Darnell, Laura V. Danai, Tyler Jacks, Shawn M. Davidson, Matthew G. Vander Heiden, Kiera M. Sapp, Ömer H. Yilmaz, Vasilena Gocheva, Sharanya Sivanand, Anna M. Westermark, Zhaoqi Li, Christopher R. Chin, Allison N. Lau, Raphael Ferreira, Jared R. Mayers
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Funder: Jane Coffin Childs Memorial Fund for Medical Research; FundRef: http://dx.doi.org/10.13039/100001033
Funder: Swedish Foundation for Strategic Research; FundRef: http://dx.doi.org/10.13039/501100001729
Funder: Knut and Alice Wallenbe
Funder: Swedish Foundation for Strategic Research; FundRef: http://dx.doi.org/10.13039/501100001729
Funder: Knut and Alice Wallenbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fde3c5e548d66f8a3851a8ddc356cb
Autor:
Evan C. Lien, David A. Tuveson, Zhaoqi Li, Tyler Jacks, Allison N. Lau, Raphael Ferreira, Christopher R. Chin, Giulia Biffi, Alicia M. Darnell, Jared R. Mayers, Nicholas J Matheson, Matthew G. Vander Heiden, Laura V. Danai, Sharanya Sivanand, Ömer H. Yilmaz, Kiera M. Sapp, Vasilena Gocheva, Anna M. Westermark, Shawn M. Davidson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1959975d018296b343c25c008cf167
https://doi.org/10.7554/elife.56782.sa2
https://doi.org/10.7554/elife.56782.sa2
Autor:
Keene L. Abbott, Lucas B. Sullivan, Purushottam D. Dixit, Elizabeth F. Gorodetsky, Aaron M. Hosios, Zhaoqi Li, Konstantine Tchourine, Matthew G. Vander Heiden, Evan C. Lien, Dennis Vitkup, Brian W. Ji, Anna M. Westermark
It is not well understood how physiological environmental conditions and nutrient availability influence cancer cell proliferation. Production of oxidized biomass, which requires regeneration of the cofactor NAD+, can limit cancer cell proliferation1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba3806914244a698b84d906bd1133d9
https://doi.org/10.1101/2020.06.08.134890
https://doi.org/10.1101/2020.06.08.134890
Autor:
Allison N. Lau, Evan C. Lien, Laura V. Danai, Kiera M. Sapp, Ömer H. Yilmaz, Vasilena Gocheva, Matthew G. Vander Heiden, Shawn M. Davidson, Raphael Ferreira, Giulia Biffi, Alicia M. Darnell, Zhaoqi Li, Nicholas J Matheson, Anna M. Westermark, Sharanya Sivanand, Christopher R. Chin, David A. Tuveson, Tyler Jacks, Jared R. Mayers
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between various cell types within a mixed population can be limited by the rapid turnover of metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9e0475fb71841d48fbb9cca2f5ebfd
Dietary interventions can change metabolite levels in the tumor microenvironment, which may then affect cancer cell metabolism to alter tumor growth1–6. Although caloric restriction (CR) and the ketogenic diet (KD) are often thought to inhibit tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c4183ab794255d8cf0d887113438a4