Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Anna M, Huckabee"'
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B Agonias, Marissa Watanabe, Danuta Szczesna-Cordary, Anna M Huckabee, Katarzyna Kazmierczak, Yemeserach Bishaw
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H881-H890
Mavacamten is a pharmaceutical that binds to myosin, and it is under investigation as a therapy for some forms of heart disease. We show that mavacamten reduces isometric tension and Ca2+ sensitivity of contraction in skinned myocardial strips from a
Autor:
Peter O, Awinda, Marissa, Watanabe, Yemeserach, Bishaw, Anna M, Huckabee, Keinan B, Agonias, Katarzyna, Kazmierczak, Danuta, Szczesna-Cordary, Bertrand C W, Tanner
Publikováno v:
Am J Physiol Heart Circ Physiol
Morbidity and mortality associated with heart disease is a growing threat to the global population, and novel therapies are needed. Mavacamten (formerly called MYK-461) is a small molecule that binds to cardiac myosin and inhibits myosin ATPase. Mava