Zobrazeno 1 - 10
of 462
pro vyhledávání: '"Anna M, Blom"'
Autor:
Veroniaina Hanitrarimalala, Izabela Bednarska, Takashi Murakami, Konstantinos S. Papadakos, Anna M. Blom
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-14 (2024)
Abstract Chemotherapy persists as the primary intervention for breast cancer, with chemoresistance posing the principal obstacle to successful treatment. Herein, we show that cartilage oligomeric matrix protein (COMP) expression leads to increased ca
Externí odkaz:
https://doaj.org/article/59a80d2c8de9467982b53e4e9147be8b
Autor:
Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirström, Konstantinos S. Papadakos, Anna M. Blom
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types of solid cancers. Thi
Externí odkaz:
https://doaj.org/article/70cd2d9352ca489783d89fb5d55c6172
Autor:
Emre Can Tuysuz, Eleni Mourati, Rebecca Rosberg, Aleksandra Moskal, Chrysostomi Gialeli, Elinn Johansson, Valeria Governa, Mattias Belting, Alexander Pietras, Anna M. Blom
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background The complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the brain, its function in gliomas, malignant brain tumors originating from glial cells, has not
Externí odkaz:
https://doaj.org/article/2cfba0cfd2094dd8a624c0aef401ef77
Autor:
Yihong Chen, Chrysostomi Gialeli, Junyan Shen, Pontus Dunér, Björn Walse, Annette Duelli, Rhawnie Caing-Carlsson, Anna M. Blom, John R. Zibert, Anna Hultgårdh Nilsson, Jan Alenfall, Chun Liang, Jan Nilsson
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107259- (2024)
The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable recep
Externí odkaz:
https://doaj.org/article/d07c8358d1374cfe9015cbdecd1009ab
Autor:
Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A. Gelderman, Timon Damelang, Gestur Vidarsson, Anna M. Blom, Elena Domínguez-Vega, Paul W. H. I. Parren, Thomas H. Sharp, Leendert A. Trouw
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, u
Externí odkaz:
https://doaj.org/article/66693f5931e04cbdb02cb3b635c4eb80
Autor:
Gabriel Strandberg, Carl M. Öberg, Anna M. Blom, Oleg Slivca, David Berglund, Mårten Segelmark, Bo Nilsson, Ali-Reza Biglarnia
Publikováno v:
Kidney International Reports, Vol 8, Iss 12, Pp 2592-2602 (2023)
Introduction: In kidney transplantation (KT), the role of the intravascular innate immune system (IIIS) in response to ischemia-reperfusion injury (IRI) is not well-understood. Here, we studied parallel changes in the generation of key activation pro
Externí odkaz:
https://doaj.org/article/4c11d7ad8a004dea8f967c01a5ad52d5
Autor:
Zhongwei Xu, Bingze Xu, Susanna L. Lundström, Àlex Moreno-Giró, Danxia Zhao, Myriam Martin, Erik Lönnblom, Qixing Li, Alexander Krämer, Changrong Ge, Lei Cheng, Bibo Liang, Dongmei Tong, Roma Stawikowska, Anna M. Blom, Gregg B. Fields, Roman A. Zubarev, Rikard Holmdahl
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of which react with type-II collagen (COL2) in articular cartilage. We previously described a subset of COL2 antibodies targeting the F4 epitope (ERGLKGHRG
Externí odkaz:
https://doaj.org/article/f1b2a298e350447faf9017b020647aaf
Autor:
Alexander Åkesson, James B. Bussel, Myriam Martin, Anna M. Blom, Jenny Klintman, Waleed Ghanima, Eva Zetterberg, Lamya Garabet
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Increased platelet destruction is central in the pathogenesis of immune thrombocytopenia. However, impaired platelet production is also relevant and its significance underlies the rationale for treatment with thrombopoietin receptor agonists (TPO-RAs
Externí odkaz:
https://doaj.org/article/4ab880211eae4cfa85a11a3095bac1dc
Autor:
Inmaculada Serrano, Ana Luque, Alexandra Ruiz-Cerulla, Sergio Navas, Anna M. Blom, Santiago Rodríguez de Córdoba, Francisco J. Fernández, M. Cristina Vega, Francisco Rodríguez-Moranta, Jordi Guardiola, Josep M. Aran
Publikováno v:
Pharmacological Research, Vol 197, Iss , Pp 106948- (2023)
The most recent and promising therapeutic strategies for inflammatory bowel disease (IBD) have engaged biologics targeting single effector components involved in major steps of the immune-inflammatory processes, such as tumor necrosis factor, interle
Externí odkaz:
https://doaj.org/article/f67ccb0a5ede42759354bfb33673e0c7
Autor:
Konstantinos S. Papadakos, Alexander Ekström, Piotr Slipek, Eleni Skourti, Steven Reid, Kristian Pietras, Anna M. Blom
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Sushi domain-containing protein 4 (SUSD4) is a recently discovered protein with unknown cellular functions. We previously revealed that SUSD4 can act as complement inhibitor and as a potential tumor suppressor. Methods In a syngen
Externí odkaz:
https://doaj.org/article/ffa37e609d214cb0acb3b113686e5eb0