Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Anna M, Barron"'
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
Joseph D. Quick, Cristian Silva, Jia Hui Wong, Kah Leong Lim, Richard Reynolds, Anna M. Barron, Jialiu Zeng, Chih Hung Lo
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Be
Externí odkaz:
https://doaj.org/article/bc395be4598848258372b3681dfdadc4
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 9, Pp 1869-1870 (2024)
Externí odkaz:
https://doaj.org/article/61914c02121f40db86a7fb07aaf57c55
Autor:
Lauren H. Fairley, Naruhiko Sahara, Ichio Aoki, Bin Ji, Tetsuya Suhara, Makoto Higuchi, Anna M. Barron
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background The translocator protein (TSPO) has been identified as a positron emission tomography (PET)-visible biomarker of inflammation and promising immunotherapeutic target for the treatment of Alzheimer’s disease (AD). While TSPO ligan
Externí odkaz:
https://doaj.org/article/6cdb02ac955b4c3c9837021740adfdb6
Publikováno v:
eLife, Vol 10 (2021)
Brain microglia and border-associated macrophages (BAMs) display distinct spatial, developmental, and phenotypic features. Although at steady state, the origins of distinct brain macrophages are well-documented, the dynamics of their replenishment in
Externí odkaz:
https://doaj.org/article/94981eef302b43279a32785b3e375d69
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging. Centella asiatica (L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Past in vivo and in vitro
Externí odkaz:
https://doaj.org/article/1436b8a3ec5d4dd098d24ec2cb2168e6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Alzheimer’s disease (AD) is an age-associated terminal neurodegenerative disease with no effective treatments. Dysfunction of innate immunity is implicated in the pathogenesis of AD, with genetic studies supporting a causative role in the disease.
Externí odkaz:
https://doaj.org/article/9cfdabe703be492591a4dbf0a9234fa7
Autor:
Lauren H. Fairley, Kei Onn Lai, Jia Hui Wong, Wei Jing Chong, Anselm Salvatore Vincent, Giuseppe D’Agostino, Xiaoting Wu, Roshan R. Naik, Anusha Jayaraman, Sarah R. Langley, Christiane Ruedl, Anna M. Barron
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Microglial phagocytosis is an energetically demanding process that plays a critical role in the removal of toxic protein aggregates in Alzheimer’s disease (AD). Recent evidence indicates that a switch in energy production from mitochondrial respira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a4281071ab4b6c9a2246c31fee872c
https://doi.org/10.1073/pnas.2209177120
https://doi.org/10.1073/pnas.2209177120
Autor:
Makoto Higuchi, Lauren H. Fairley, Tetsuya Suhara, Naruhiko Sahara, Ichio Aoki, Bin Ji, Anna M. Barron
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background The translocator protein (TSPO) has been identified as a positron emission tomography (PET)-visible biomarker of inflammation and promising immunotherapeutic target for the treatment of Alzheimer’s disease (AD). While TSPO ligands have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa3b8fee2b4c970cdf93ed813bc71f9
https://doaj.org/article/6cdb02ac955b4c3c9837021740adfdb6
https://doaj.org/article/6cdb02ac955b4c3c9837021740adfdb6
Publikováno v:
Molecular Neurobiology. 58:550-563
Pharmacological studies have implicated the translocator protein (TSPO) in the regulation of complex behaviors including anxiety and depression, effects thought to be mediated by increased synthesis of neuroactive steroid hormones. However, TSPO func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929710618963f9c66b8c029e4700eb3e
https://doi.org/10.1007/s12035-020-02136-5
https://doi.org/10.1007/s12035-020-02136-5