Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anna Loksztejn"'
Publikováno v:
Bio-Protocol, Vol 11, Iss 8 (2021)
(1,3)-β-d-Glucan synthase (GS) is an essential enzyme for fungal cell wall biosynthesis that catalyzes the synthesis of (1,3)-β-d-glucan, a major and vital component of the cell wall. GS is a proven target of antifungal antibiotics including FDA-ap
Externí odkaz:
https://doaj.org/article/e6e115c6db1642d59dd79408084dc249
Autor:
J. Andrew Alspaugh, Abhishek Chhetri, Mi Jung Kim, Anna Loksztejn, Kaila M. Pianalto, Hai P Nguyen, Kenichi Yokoyama, Jiyong Hong
Publikováno v:
Biochemistry. 59:682-693
(1,3)-β-D-Glucan synthase (GS) catalyzes formation of the linear (1,3)-β-D-glucan in the fungal cell wall, and is a target of clinically approved antifungal antibiotics. The catalytic subunit of GS, FKS protein, does not exhibit significant sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099ed0e4784d421e25988b884c058a7b
https://doi.org/10.1021/acs.biochem.9b00896
https://doi.org/10.1021/acs.biochem.9b00896
Publikováno v:
Advances in experimental medicine and biology. 1256
Increasing evidence over the past two decades points to a pivotal role for immune mechanisms in age-related macular degeneration (AMD) pathobiology. In this chapter, we will explore immunological aspects of AMD, with a specific focus on how immune me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbf64dc2f07002f4647ef6f0053c4d81
https://pubmed.ncbi.nlm.nih.gov/33848001
https://pubmed.ncbi.nlm.nih.gov/33848001
Publikováno v:
Age-related Macular Degeneration ISBN: 9783030660130
Increasing evidence over the past two decades points to a pivotal role for immune mechanisms in age-related macular degeneration (AMD) pathobiology. In this chapter, we will explore immunological aspects of AMD, with a specific focus on how immune me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98357e693b31c72c9c7d39f77dc28f82
https://doi.org/10.1007/978-3-030-66014-7_6
https://doi.org/10.1007/978-3-030-66014-7_6
Publikováno v:
Bio Protoc
(1,3)-β-d-Glucan synthase (GS) is an essential enzyme for fungal cell wall biosynthesis that catalyzes the synthesis of (1,3)-β-d-glucan, a major and vital component of the cell wall. GS is a proven target of antifungal antibiotics including FDA-ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f3db8c207f7a4ce8d4da04863fcd7f
https://pubmed.ncbi.nlm.nih.gov/34124296
https://pubmed.ncbi.nlm.nih.gov/34124296
Autor:
Majda Hadziahmetovic, Ying Xu, Miroslav Pajic, Qitong Gao, Scott W. Cousins, Joshua Amason, Anna Loksztejn
Publikováno v:
Translational Vision Science & Technology
Purpose To develop a neural network (NN)-based approach, with limited training resources, that identifies and counts the number of retinal pigment epithelium (RPE) cells in confocal microscopy images obtained from cell culture or mice RPE/choroid fla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9587c0c3536dc23a8f0471d61058d19
http://europepmc.org/articles/PMC7414692
http://europepmc.org/articles/PMC7414692
Autor:
Anna Loksztejn, Li Chen, Kenichi Yokoyama, Yan Li, Xingzhong Liu, Gerald F. Bills, Qun Yue, Edd Felix, Ningyan Zhang, Zhiqiang An
Publikováno v:
ACS Chemical Biology. 11:2724-2733
Pneumocandins are lipohexapeptides of the echinocandin family that inhibit fungal 1,3-β-glucan synthase. Most of the pathway steps have been identified previously. However, the lipoinitiation reaction has not yet been experimentally verified. Herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15979085b4a11c794a1b2656ca253caf
https://doi.org/10.1021/acschembio.6b00604
https://doi.org/10.1021/acschembio.6b00604
Autor:
Mahir Rabbi, Piotr E. Marszalek, Michael S. Humeniuk, Anna Loksztejn, Changhong Ke, Yong Jiang, Minkyu Kim
Publikováno v:
Biophysical Journal. 96:2918-2925
We report the results of direct measurements by atomic force microscopy of solvent-driven structural transitions within polyadenylic acid (poly(A)). Both atomic force microscopy imaging and pulling measurements reveal complex strand arrangements with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5f93322018849a14e9089e94a34aaa
https://doi.org/10.1016/j.bpj.2008.12.3939
https://doi.org/10.1016/j.bpj.2008.12.3939
Publikováno v:
Bioelectrochemistry. 72:34-40
The in vivo formation of β-pleated protein aggregates underlies a number of fatal neurodegenerative disorders, such as Alzheimer disease. Since molecular mechanisms of protein misfolding and aggregation remain poorly understood, this has been callin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc5856778aa50b815231772bad54689
https://doi.org/10.1016/j.bioelechem.2007.07.004
https://doi.org/10.1016/j.bioelechem.2007.07.004
Autor:
Roland Winter, Smirnovas, Stefan Grudzielanek, Revanur Ravindra, Nicolini C, Anna Loksztejn, Wojciech Dzwolak, Ralf Jansen, Sylwester Porowski
Publikováno v:
Biochemistry. 44:8948-8958
A model cosolvent, ethanol, has profound and diversified effects on the amyloidogenic self-assembly of insulin, yielding spectroscopically and morphologically distinguishable forms of beta-aggregates. The alcohol reduces hydrodynamic radii of insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecb8b77ef088e1cb0f7a19e4c210ecc
https://doi.org/10.1021/bi050281t
https://doi.org/10.1021/bi050281t