Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anna Liza B. Durol"'
Autor:
von Moltke Ll, Johanna P. Daily, David J. Greenblatt, Richard I. Shader, Anna Liza B. Durol, Jennifer A. Graf, Jerold S. Harmatz, Hoffman Jl, Polyxane Mertzanis
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes. 24:129-136
BACKGROUND The viral protease inhibitor ritonavir has the capacity to inhibit and induce the activity of cytochrome P450-3A (CYP3A) isoforms, leading to drug interactions that may influence the efficacy and toxicity of other antiretroviral therapies,
Autor:
Lisa L. von Moltke, Richard I. Shader, Su Xiang Duan, Jennifer A. Graf, Anna Liza B. Durol, Jerold S. Harmatz, Polyxane Mertzanis, Molly Counihan, David J. Greenblatt, C. Eugene Wright
Publikováno v:
Clinical Pharmacology & Therapeutics. 64:278-285
Background Macrolide antimicrobial agents may impair hepatic clearance of drugs metabolized by cytochrome P4503A isoforms. Potential interactions of triazolam, a substrate metabolized almost entirely by cytochrome P4503A in humans, with 3 commonly pr
Publikováno v:
European Journal of Clinical Pharmacology. 56:259-261
Objective: Biotransformation of triazolam to its α-hydroxy and 4-hydroxy metabolites by human liver microsomes in vitro was used as an index of human cytochrome P 450 3A (CYP3A) activity. Results: The reaction was strongly inhibited by co-incubation
Autor:
Anna Liza B. Durol, Johanna P. Daily, Lisa L. von Moltke, Jennifer A. Graf, Polyxane Mertzanis, Richard I. Shader, David J. Greenblatt, Jonathan L. Hoffman, Jerold S. Harmatz
Publikováno v:
Clinical pharmacology and therapeutics. 67(4)
Background Pharmacokinetic interactions involving antiretroviral therapies may critically influence the efficacy and toxicity of these drugs, as well as pharmacologic treatments of coincident or complicating diseases. The viral protease inhibitor rit
Publikováno v:
Journal of analytical toxicology. 21(5)
Zolpidem, an imidazopyradine hypnotic agent, can be quantitated by high-performance liquid chromatography (HPLC) with fluorescence detection. After the addition of a structurally related internal standard (propyl-zolpidem), plasma samples were double