Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anna Laura Aloisi"'
Autor:
Marco Trerotola, Emanuela Guerra, Zeeshan Ali, Anna Laura Aloisi, Martina Ceci, Pasquale Simeone, Angela Acciarito, Paola Zanna, Giovanna Vacca, Antonella D'Amore, Khouloud Boujnah, Valeria Garbo, Antonino Moschella, Rossano Lattanzio, Saverio Alberti
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 415-428 (2021)
Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region, betw
Externí odkaz:
https://doaj.org/article/7708194bebce4cc9aac7e067d9b67fc1
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Trop-2 drives the recruitment of Akt to the cell membrane via its PH domain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6453b0d216c6fcb1ef436fbbef877bb3
https://doi.org/10.1158/1078-0432.22455074
https://doi.org/10.1158/1078-0432.22455074
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Supplementary Methods: Protein microarrays,Multiplex Western blotting,Confocal time-lapse microscopy, Western blotting, Immunohistochemistry, 3D structure analysis; Supplementary Table 3:Breast cancer case series clinical and pathological parameters;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba75a6080718fa67a101fe165cdf5b5
https://doi.org/10.1158/1078-0432.22455068.v1
https://doi.org/10.1158/1078-0432.22455068.v1
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Trop-2 proteome profiling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033aa433674f6a3f16094401d6f03d27
https://doi.org/10.1158/1078-0432.22455080
https://doi.org/10.1158/1078-0432.22455080
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Purpose: Inhibition of AKT is a key target area for personalized cancer medicine. However, predictive markers of response to AKT inhibitors are lacking. Correspondingly, the AKT-dependent chain of command for tumor growth, which will mediate AKT-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aba9c58904fd6f147083dbd1b225b79
https://doi.org/10.1158/1078-0432.c.6522914
https://doi.org/10.1158/1078-0432.c.6522914
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Trop-2-associated functions driven by Akt-phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4e9ca569a57d25e139431b62b0e600
https://doi.org/10.1158/1078-0432.22455062
https://doi.org/10.1158/1078-0432.22455062
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Proteomic analysis of the Trop-2 signal transduction network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d906c80096ffb439e1004dd789136b9
https://doi.org/10.1158/1078-0432.22455065
https://doi.org/10.1158/1078-0432.22455065
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
This video shows MTE 4-14 cells cotransfected with Akt PH domain-EGFP (green) and Trop-2-mRFP1 (red). Recruitment and colocalization of Akt PH domain-EGFP with Trop-2-mRFP1 at the cell membrane was found to be quantitative and dynamic. The time lapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b50922ac8cee57b86b418c922cdb3
https://doi.org/10.1158/1078-0432.22455059.v1
https://doi.org/10.1158/1078-0432.22455059.v1
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Trop-2-dependent Akt signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc39611b9f8e840ae6f5ac805e0a05d
https://doi.org/10.1158/1078-0432.22455077
https://doi.org/10.1158/1078-0432.22455077
Autor:
Saverio Alberti, Mauro Piantelli, Rossano Lattanzio, Rossana La Sorda, Antonella D'Amore, Valeria Relli, Andrea Sacchetti, Pasquale Simeone, Anna Laura Aloisi, Romina Tripaldi, Marco Trerotola, Emanuela Guerra
Supplemental Figure 4: Trop-2-independent cell growth reduction by inhibitors of mTOR, NF-kB and JNK; Supplementary Figure 5: Dose-response curves for signaling pathway inhibitors; Supplementary Figure 6: Correlated expression of Trop-2, phospho-T308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684f1c5a4a508d356b81aadfd62affc7
https://doi.org/10.1158/1078-0432.22455071.v1
https://doi.org/10.1158/1078-0432.22455071.v1