Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anna Largajolli"'
Autor:
Akshita Chawla, Anna Largajolli, Azher Hussain, Huub Kleijn, Sihem Ait‐Oudhia, Judith Anton, Hari Krishna Ananthula, Jesse Nussbaum, Carmen La Rosa, Ferdous Gheyas
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 8, Pp 1107-1118 (2023)
Abstract Gefapixant, a P2X3‐receptor antagonist, demonstrated objective and subjective efficacy in individuals with refractory or unexplained chronic cough. We report a population pharmacokinetic (PopPK) analysis that characterizes gefapixant pharm
Externí odkaz:
https://doaj.org/article/f02f6d139f104ee19b3664f8304c3f9a
Autor:
Bhargava Kandala, Nele Plock, Akshita Chawla, Anna Largajolli, Seth Robey, Kenny Watson, Raj Thatavarti, Sheri A. Dubey, S.Y. Amy Cheung, Rik de Greef, Julie Stone, Jeffrey R. Sachs
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104264- (2022)
Summary: Background: The COVID-19 pandemic has increased the need for innovative quantitative decision tools to support rapid development of safe and efficacious vaccines against SARS-CoV-2. To meet that need, we developed and applied a model-based m
Externí odkaz:
https://doaj.org/article/de1aa37726f44b35900d070763f50f39
Autor:
Michael J. Hanley, Paul Diderichsen, Benjamin Rich, Anna Largajolli, Emilie Schindler, Alexander Vorog, Karthik Venkatakrishnan, Neeraj Gupta
Publikováno v:
Clinical Pharmacology & Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0372136baab207df723c9189d9707033
https://doi.org/10.1002/cpt.2956
https://doi.org/10.1002/cpt.2956
Autor:
Neeraj Gupta, Anna Largajolli, Han Witjes, Paul M. Diderichsen, Steven Zhang, Michael J. Hanley, Jianchang Lin, Minal Mehta
Publikováno v:
Clinical pharmacology and therapeutics. 112(2)
Mobocertinib is an oral tyrosine kinase inhibitor approved for treatment of patients with locally advanced or metastatic non-small cell lung cancer (mNSCLC) with epidermal growth factor receptor gene (EGFR) exon 20 insertion (ex20ins) mutations previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1c658035b2ad8a0ae8318a34568339
https://pubmed.ncbi.nlm.nih.gov/35467009
https://pubmed.ncbi.nlm.nih.gov/35467009
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
Chronic obstructive pulmonary disease (COPD) is a chronic obstructive disease of the airways. An exacerbation of COPD is defined as shortness of breath, cough, and sputum production. New therapies for COPD exacerbations are examined in clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5ae1653446b562e6cfbd40c6c438f6
http://europepmc.org/articles/PMC6848253
http://europepmc.org/articles/PMC6848253
Autor:
Anna Largajolli, Malidi Ahamadi, Akshita Chawla, Thomas Kerbusch, Ferdous Gheyas, Rik de Greef, Paul M. Diderichsen, Han Witjes, Casey B. Davis
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 46:273-285
Stepwise covariate modeling (SCM) is a widely used tool in pharmacometric analyses to identify covariates that explain between-subject variability (BSV) in exposure and exposure–response relationships. However, this approach has several potential w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062e42b8044e95629dbc4ff9a69c7c46
https://doi.org/10.1007/s10928-019-09635-6
https://doi.org/10.1007/s10928-019-09635-6
Autor:
Anna Largajolli, Nele Plock, Bhargava Kandala, Akshita Chawla, Seth H Robey, Kenny Watson, Raj Thatavarti, Sheri Dubey, S Y Amy Cheung, Rik de Greef, Jeffrey R Sachs
Publikováno v:
Open Forum Infectious Diseases
Background Several COVID-19 vaccines have been authorized, and the need for rapid, further modification is anticipated. This work uses a Model-Based Meta-Analysis (MBMA) to relate, across species, immunogenicity to peak viral load (VL) after challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42956c137219474f5e9e4c0d07e525f9
http://europepmc.org/articles/PMC8690825
http://europepmc.org/articles/PMC8690825
Publikováno v:
Pharmaceutical Research. 36
PurposeFor some biological systems, there exist several models with somewhat different features and perspectives. We propose an evaluation method for NLME models by analyzing real and simulated data from the model of main interest using a structurall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488f0c6b3bda8d45b9da876b1115ce8b
https://doi.org/10.1007/s11095-019-2592-9
https://doi.org/10.1007/s11095-019-2592-9
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 134
This paper describes the improved integrated minimal model for healthy subjects and patients with type 2 diabetes and the work leading up to this model. The original integrated minimal model characterizes simultaneously glucose and insulin following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3e3f9cad2eff199dae0dbe716def6b
https://pubmed.ncbi.nlm.nih.gov/30978382
https://pubmed.ncbi.nlm.nih.gov/30978382
Autor:
Santica M. Marcovina, Anna Largajolli, Kris V. Kowdley, Kristina M. Utzschneider, Steven E. Kahn, James E. Nelson, Alessandra Bertoldo, Matthew M. Yeh
Publikováno v:
Journal of Diabetes and its Complications. 28:177-184
Aims We sought to determine whether NAFLD is associated with poorer β-cell function and if any β-cell dysfunction is associated with abnormal markers of iron or inflammation. Methods This was a cross-sectional study of 15 non-diabetic adults with N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985a9df18a021ddaa1745205e0f30e60
https://doi.org/10.1016/j.jdiacomp.2013.11.007
https://doi.org/10.1016/j.jdiacomp.2013.11.007