Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anna L.R. Xavier"'
Autor:
Arthur Liesz, Shan Zhao, Martin Kerschensteiner, Chenchen Pan, Hanno Steinke, Arnaldo Parra-Damas, Ruiyao Cai, Corinne Benakis, Markus Rempfler, Ali Ertürk, Mihail Ivilinov Todorov, Harsharan S. Bhatia, Sabine Liebscher, Anna L.R. Xavier, Bjoern H. Menze, Benjamin T. Kress, Benjamin Förstera, Delphine Theodorou, Ingo Bechmann, Leander Mrowka, Alireza Ghasemigharagoz
Publikováno v:
Nature neuroscience
Analysis of entire transparent rodent bodies after clearing could provide holistic biological information in health and disease, but reliable imaging and quantification of fluorescent protein signals deep inside the tissues has remained a challenge.
Autor:
Humberto Mestre, Anna L.R. Xavier, Helene Benveniste, Simon Sanggaard, Serhii Kostrikov, Albert Gjedde, Kristian Nygaard Mortensen, Hedok Lee
Publikováno v:
Nygaard Mortensen, K, Sanggaard, S, Mestre, H, Lee, H, Kostrikov, S, Xavier, A L R, Gjedde, A, Benveniste, H & Nedergaard, M 2019, ' Impaired Glymphatic Transport in Spontaneously Hypertensive Rats ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, no. 32, pp. 6365-6377 . https://doi.org/10.1523/JNEUROSCI.1974-18.2019
Mortensen, K N, Sanggaard, S, Mestre, H, Lee, H, Kostrikov, S, Xavier, A L R, Gjedde, A, Benveniste, H & Nedergaard, M 2019, ' Impaired Glymphatic Transport in Spontaneously Hypertensive Rats ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, no. 32, pp. 6365-6377 . https://doi.org/10.1523/JNEUROSCI.1974-18.2019
The Journal of Neuroscience
Mortensen, K N, Sanggaard, S, Mestre, H, Lee, H, Kostrikov, S, Xavier, A L R, Gjedde, A, Benveniste, H & Nedergaard, M 2019, ' Impaired Glymphatic Transport in Spontaneously Hypertensive Rats ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, no. 32, pp. 6365-6377 . https://doi.org/10.1523/JNEUROSCI.1974-18.2019
The Journal of Neuroscience
The glymphatic system is a brain-wide cerebrospinal fluid (CSF) transport system that utilizes the perivascular space for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and hypertension that causes vascular patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5609b950c02dad2abdf488d51031144b
https://curis.ku.dk/ws/files/246825356/Impaired_Glymphatic_Transport_in_Spontaneously_Hypertensive_Rats.pdf
https://curis.ku.dk/ws/files/246825356/Impaired_Glymphatic_Transport_in_Spontaneously_Hypertensive_Rats.pdf
Autor:
Markus Rempfler, Arthur Liesz, Shan Zhao, Martin Kerschensteiner, Anna L.R. Xavier, Harsharan S. Bhatia, Bjoern H. Menze, Foerstera B, Benjamin T. Kress, Corinne Benakis, Ali Ertürk, Leander Mrowka, Ruiyao Cai, Mihail Ivilinov Todorov, Chenchen Pan, Alireza Ghasemigharagoz, M. Nedergaard, Delphine Theodorou
Analysis of entire transparent rodent bodies could provide holistic information on biological systems in health and disease. However, it has been challenging to reliably image and quantify signal from endogenously expressed fluorescent proteins in la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc832745b2ffb65d79596458ef0b1d71
https://doi.org/10.1101/374785
https://doi.org/10.1101/374785
Autor:
Wenyan Zou, Benjamin A. Plog, Ruth M. Castellanos Rivera, Benjamin T. Kress, Iben Lundgaard, Tinglin Pu, Yoichiro Abe, Aravind Asokan, Xiaowen Wang, Anna L.R. Xavier, Matthew J. Simon, Masato Yasui, Ting Du, Humberto Mestre, Hajime Hirase, Alexander S. Thrane, Hiromu Monai, Giridhar Murlidharan, Lauren M. Hablitz, Ming Xiao, Virginia Plá, Martin M. Pike, John H. Thomas, Weixi Feng, Jeffrey J. Iliff
Publikováno v:
eLife
eLife, Vol 7 (2018)
Mestre, H, Hablitz, L M, Xavier, A L R, Feng, W, Zou, W, Pu, T, Monai, H, Murlidharan, G, Rivera, R M C, Simon, M J, Pike, M M, Pla, V, Du, T, Kress, B T, Wang, X, Plog, B A, Thrane, A S, Lundgaard, I, Abe, Y, Yasui, M, Thomas, J H, Xiao, M, Hirase, H, Asokan, A, Iliff, J J & Nedergaard, M 2018, ' Aquaporin-4-dependent glymphatic solute transport in the rodent brain ', eLife, vol. 7, :e40070 . https://doi.org/10.7554/eLife.40070
eLife, Vol 7 (2018)
Mestre, H, Hablitz, L M, Xavier, A L R, Feng, W, Zou, W, Pu, T, Monai, H, Murlidharan, G, Rivera, R M C, Simon, M J, Pike, M M, Pla, V, Du, T, Kress, B T, Wang, X, Plog, B A, Thrane, A S, Lundgaard, I, Abe, Y, Yasui, M, Thomas, J H, Xiao, M, Hirase, H, Asokan, A, Iliff, J J & Nedergaard, M 2018, ' Aquaporin-4-dependent glymphatic solute transport in the rodent brain ', eLife, vol. 7, :e40070 . https://doi.org/10.7554/eLife.40070
The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquap
Autor:
Maiken Nedergaard, Iben Lundgaard, Nanhong Lou, Simon Sanggaard, Qianliang Li, Stephanie von Holstein-Rathlou, Natalie Linea Hauglund, Anna L.R. Xavier
Publikováno v:
Journal of Visualized Experiments.
Cisterna magna cannulation (CMc) is a straightforward procedure that enables direct access to the cerebrospinal fluid (CSF) without operative damage to the skull or the brain parenchyma. In anesthetized rodents, the exposure of the dura mater by blun
Microglia are integral functional elements of the central nervous system, but the contribution of these cells to the structural integrity of the neurovascular unit has not hitherto been assessed. We show here that following blood–brain barrier (BBB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3272be823a57b8b731b78f5029ec5d91
https://europepmc.org/articles/PMC4743790/
https://europepmc.org/articles/PMC4743790/
Autor:
Andressa S. Freitas, Maira Monteiro Fróes, Cecilia Hedin-Pereira, João R. L. Menezes, Anna L.R. Xavier, Carla M. Furtado
Publikováno v:
Developmental Neurobiology. 72:1482-1497
In this study, we have analyzed the specific contribution of the cortical radial glia (RG) for gap junctional communication (GJC) within the postnatal subventricular zone (SVZ). To specifically target RG as source of dye-coupling in situ, we have dev
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Frontiers in Cellular Neuroscience, Vol 9 (2015)
The full spectrum of cellular interactions within CNS neurogenic niches is still poorly understood. Only recently has the monocyte counterpart of the nervous system, the microglial cells, been described as an integral cellular component of neurogenic
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 369(1654)
Microglia constitute as much as 10–15% of all cells in the mammalian central nervous system (CNS) and are the only glial cells that do not arise from the neuroectoderm. As the principal CNS immune cells, microglial cells represent the first line of
Autor:
Luciana Romão, Celina Garcia, Jorge Marcondes de Souza, Ana Helena Pereira Correia, Anna L.R. Xavier, Fernanda Tovar-Moll, Nathalie Henriques Silva Canedo, Flavia Regina Souza Lima, Grasiella M. Ventura, Anna Carolina Carvalho da Fonseca, Fernanda Meirelles, João R. L. Menezes, Luiz Henrique Medeiros Geraldo, Luiz Gustavo Dubois, Vivaldo Moura-Neto
Publikováno v:
BMC Cancer
Background Glioblastoma (GBM) is the most common primary brain tumor and the most aggressive glial tumor. This tumor is highly heterogeneous, angiogenic, and insensitive to radio- and chemotherapy. Here we have investigated the progression of GBM pro