Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anna L. Shen"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Crystal structures of human long-chain acyl-CoA dehydrogenase (LCAD) and the catalytically inactive Glu291Gln mutant, have been determined. These structures suggest that LCAD harbors functions beyond its historically defined role in mitochon
Externí odkaz:
https://doaj.org/article/831a8a97f9eb43aca757c58b2f4a5a3c
Familial isolated pituitary adenoma is independent of Ahr genotype in a novel mouse model of disease
Autor:
Anna L. Shen, Susan M. Moran, Edward N. Glover, Bernice C. Lin, Patrick R. Carney, Christopher A. Bradfield
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28231- (2024)
Human familial isolated pituitary adenoma (FIPA) has been linked to germline heterozygous mutations in the gene encoding the aryl hydrocarbon receptor-interacting protein (AIP, also known as ARA9, XAP2, FKBP16, or FKBP37). To investigate the hypothes
Externí odkaz:
https://doaj.org/article/b1266fa3082948d7acb79f29ee1bb32f
Autor:
Emmanuel Vazquez-Rivera, Brenda L. Rojas, Jessica C. Parrott, Anna L. Shen, Yongna Xing, Patrick R. Carney, Christopher A. Bradfield
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1-11 (2022)
Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS domain is found in proteins throughout Archaea, Bacteria, and Eukarya and often binds small-molecules, supports pr
Externí odkaz:
https://doaj.org/article/30663714268b47fd894efbc2d346cd02
Autor:
Chuanwu Xia, Baoying Lou, Zhuji Fu, Al-Walid Mohsen, Anna L. Shen, Jerry Vockley, Jung-Ja P. Kim
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103153- (2021)
Summary: The dual function protein ACAD9 catalyzes α,β-dehydrogenation of fatty acyl-CoA thioesters in fatty acid β-oxidation and is an essential chaperone for mitochondrial respiratory complex I (CI) assembly. ACAD9, ECSIT, and NDUFAF1 interact t
Externí odkaz:
https://doaj.org/article/9461e48e071d486eaf8a2d268bf1c0d2
Autor:
E Vazquez-Rivera, Patrick R. Carney, Christopher A. Bradfield, Anna L. Shen, Yongna Xing, Brenda L Rojas, Jessica C. Parrott
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 9, Iss, Pp 1-11 (2022)
Toxicology Reports, Vol 9, Iss, Pp 1-11 (2022)
Graphical abstract
Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS domain is found in proteins throughout Archaea, Bacteria, and Eukarya and often binds smal
Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS domain is found in proteins throughout Archaea, Bacteria, and Eukarya and often binds smal
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185094 (2017)
Retinal phenotypes of the PPCD1 mouse, a mouse model of posterior polymorphous corneal dystrophy, have been characterized. PPCD1 mice on the DBA/2J background (D2.Ppcd1) have previously been reported to develop an enlarged anterior chamber due to epi
Externí odkaz:
https://doaj.org/article/cb1f21391e244ba2898c0f471c917990
Autor:
Baoying Lou, Chuanwu Xia, Zhuji Fu, Al-Walid Mohsen, Anna L. Shen, Jung-Ja P. Kim, Jerry Vockley
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103153-(2021)
iScience
iScience
Summary The dual function protein ACAD9 catalyzes α,β-dehydrogenation of fatty acyl-CoA thioesters in fatty acid β-oxidation and is an essential chaperone for mitochondrial respiratory complex I (CI) assembly. ACAD9, ECSIT, and NDUFAF1 interact to
Autor:
Jean Krutmann, Christopher A. Bradfield, Melina Mescher, Jeremiah S. Yee, Dieter Lang, Katharina M. Rolfes, Thomas Haarmann-Stemmann, Anna L. Shen, Christian Vogeley, Julia Tigges
Publikováno v:
Archives of Toxicology. 93:1917-1926
The Toll-like receptor 7 agonist imiquimod (IMQ) is an approved drug for the topical treatment of various skin diseases that, in addition, is currently tested in multiple clinical trials for the immunotherapy of various types of cancers. As all of th
Publikováno v:
Arch Biochem Biophys
The influence of the side chains and positioning of the carboxy-terminal residues of NADPH-cytochrome P450 oxidoreductase (CYPOR) on catalytic activity, structure of the carboxy terminus, and interaction with cofactors has been investigated. A tandem
Autor:
Jung-Ja P. Kim, Panida Duangkaew, Chuanwu Xia, Anna L. Shen, Jimmy B. Feix, Rattanawadee Kotewong, Pornpimol Rongnoparut
Publikováno v:
Biochemistry. 58(19)
NADPH-cytochrome P450 oxidoreductase (CYPOR), the essential flavoprotein of the microsomal cytochrome P450 monooxygenase system, is anchored in the phospholipid bilayer by its amino-terminal membrane-binding domain (MBD), which is necessary for effic