Výsledky vyhledávání - "Anna L. Marshall"

A phase I study to determine the effect of tamoxifen on the pharmacokinetics of a single 250 mg oral dose of gefitinib (IRESSA) in healthy male volunteers

Autor: Anna V. Robinson, Merran Macpherson, Mireille Cantarini, Christopher Bailey, Anna L. Marshall

Publikováno v: Cancer Chemotherapy and Pharmacology. 56:557-562

Objectives: To determine the effect of tamoxifen on the pharmacokinetics of a single 250 mg oral dose of gefitinib (IRESSA) in healthy volunteers. Methods: An open-label, single-center, phase I study in healthy male volunteers. Each volunteer receive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65a1ffe6d3790dca5655aefdd99f16e
https://doi.org/10.1007/s00280-005-1007-2

Zobrazit plný text záznamu

Factors determining the optimal body site and method for obtaining punch biopsies of human skin as a tissue in which to assess pharmacodynamic and pharmacokinetic endpoints in drug development studies

Autor: M. Cockerill, Paul D. Smith, P J Laud, Anna L. Marshall, D R Camidge, M. J. Davies, A. Hughes

Publikováno v: Scopus-Elsevier

There are potential advantages to detecting pharmacodynamic (PD) and pharmacokinetic (PK) endpoints in a tissue-based compartment such as the skin during the development of molecularly targeted drugs. We explored regional differences between inner ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cc51e486ecad9ad9367cfc227ed4e2
https://pubmed.ncbi.nlm.nih.gov/16032432

Zobrazit plný text záznamu

Relative bioavailability and safety profile of gefitinib administered as a tablet or as a dispersion preparation via drink or nasogastric tube: results of a randomized, open-label, three-period crossover study in healthy volunteers

Autor: Christopher Bailey, Anna L. Marshall, Robert Smith, Teresa McFarquhar, Mireille Cantarini

Publikováno v: Clinical therapeutics. 26(10)

Background: Many patients with head and neck cancer have difficulty swallowing tablet formulations ofmedications, and use of dispersion preparations may be advantageous. Objective: The aim of the present study was to determine the relative bioavailab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f85622db002d91d6906e42e097f29e
https://pubmed.ncbi.nlm.nih.gov/15598479

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání