Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anna L. Cheng"'
Publikováno v:
Human Molecular Genetics. 9:2859-2867
Expansion of a polyglutamine repeat in huntingtin causes Huntington's disease (HD). Although full-length huntingtin is predominantly distributed in the cytoplasm, N-terminal fragments of huntingtin with expanded polyglutamine tracts are able to accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfee916781f115a0ed5bfe6655573381
https://doi.org/10.1093/hmg/9.19.2859
https://doi.org/10.1093/hmg/9.19.2859
Publikováno v:
Human Molecular Genetics. 8:1227-1236
How aggregates of polyglutamine proteins are involved in the neurological symptoms of glutamine repeat diseases is unknown. We show that huntingtin aggregates are present in the neuronal processes of transgenic mice that express exon 1 of the Hunting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab8bab85a2a7c341db09bed8a9ec2c2
https://doi.org/10.1093/hmg/8.7.1227
https://doi.org/10.1093/hmg/8.7.1227
Publikováno v:
Journal of Biological Chemistry. 273:33367-33373
The molecular mechanisms that regulate the proliferation and differentiation of intestinal mucosal epithelial cells are not well understood. Keratinocyte growth factor (KGF) is an epithelial cell-specific growth factor that may be involved in the mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a58da5e8fd025601ca16e019e68994
https://doi.org/10.1074/jbc.273.50.33367
https://doi.org/10.1074/jbc.273.50.33367
Publikováno v:
Molecular and cellular biology. 22(5)
Polyglutamine expansion causes Huntington disease (HD) and at least seven other neurodegenerative diseases. In HD, N-terminal fragments of huntingtin with an expanded glutamine tract are able to aggregate and accumulate in the nucleus. Although intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5deedb325c56bba75fa22bd57ee162
https://pubmed.ncbi.nlm.nih.gov/11839795
https://pubmed.ncbi.nlm.nih.gov/11839795
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(13)
Expanded polyglutamine tracts cause huntingtin and other proteins to accumulate and aggregate in neuronal nuclei. Whether the intranuclear aggregation or localization of a polyglutamine protein initiates cellular pathology remains controversial. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52de616d4370368a03597503ba5b5d56
https://pubmed.ncbi.nlm.nih.gov/10377328
https://pubmed.ncbi.nlm.nih.gov/10377328