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pro vyhledávání: '"Anna L. Bottomley"'
Publikováno v:
Toxicologic Pathology. 43:1015-1024
Neurohistopathological changes in the brain were assessed in juvenile beagle dogs given vigabatrin at 30 or 100 mg/kg/day by oral gavage from postnatal day 22 (PND22) until 16 weeks of age (PND112), when brain myelination is considered to reach the a
Autor:
Hanne Offenberg, Julie M. Larsen, Alison Rowles, Caroline E. Rasmussen, Jette Nowak, Anna L. Bottomley
Publikováno v:
Toxicologic pathology. 44(5)
Nonacog beta pegol is a 40-kDa polyethylene glycosylated (PEGylated) human recombinant coagulation factor IX, intended for the treatment of hemophilia B. Human coagulation factors are immunogenic in animals; therefore, to evaluate the long-term toxic