Výsledky vyhledávání - "Anna L Lazzell"

Akademický článek

Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease.

Autor: Ashok K Chaturvedi, Anna L Lazzell, Stephen P Saville, Floyd L Wormley, Carlos Monteagudo, Jose L Lopez-Ribot

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20449 (2011)

Understanding the pathogenesis of infectious disease requires the examination and successful integration of parameters related to both microbial virulence and host responses. As a practical and powerful method to control microbial gene expression, in

Externí odkaz: https://doaj.org/article/3bb94cde87fd46d4988ff9c45b72af73

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Filamentation Is Associated with Reduced Pathogenicity of Multiple Non-albicans Candida Species

Autor: Mohua Banerjee, David Kadosh, Anna L. Lazzell, Jose L. Lopez-Ribot, Jesus A. Romo

Publikováno v: mSphere
mSphere, Vol 4, Iss 5 (2019)
mSphere, Vol 4, Iss 5, p e00656-19 (2019)

Many immunocompromised individuals, including HIV/AIDS and cancer patients, are susceptible to candidiasis. About half of all cases are caused by the major fungal pathogen Candida albicans, whereas the remainder are due to less pathogenic non-albican

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d254b5d5b87fd547d441b7213f38ffad
http://europepmc.org/articles/PMC6796982

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Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation

Autor: Jesus A. Romo, Christopher G. Pierce, Ashok K. Chaturvedi, Anna L. Lazzell, Stanton F. McHardy, Stephen P. Saville, Jose L. Lopez-Ribot, Joseph Heitman

Publikováno v: mBio, Vol 8, Iss 6 (2017)
mBio
mBio, Vol 8, Iss 6, p e01991-17 (2017)

Candida albicans remains the main etiologic agent of candidiasis, the most common fungal infection and now the third most frequent infection in U.S. hospitals. The scarcity of antifungal agents and their limited efficacy contribute to the unacceptabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661ce81599e0af81fe88cf7424ee5fac
https://journals.asm.org/doi/10.1128/mBio.01991-17

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Ppg1, a PP2A-Type Protein Phosphatase, Controls Filament Extension and Virulence in Candida albicans

Autor: Mohammad T. Albataineh, David Kadosh, Jose L. Lopez-Ribot, Anna L. Lazzell

Publikováno v: Eukaryotic Cell. 13:1538-1547

Candida albicans , a major human fungal pathogen, is the primary cause of invasive candidiasis in a wide array of immunocompromised patients. C. albicans virulence requires the ability to undergo a reversible morphological transition from yeast to fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80f1d0c1ae00f1d26a8937f9b4dc311
https://doi.org/10.1128/ec.00199-14

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Examination of the pathogenic potential of Candida albicans filamentous cells in an animal model of haematogenously disseminated candidiasis

Autor: Sara M. Reinhard, Ian A. Cleary, Derek P. Thomas, Carlos Monteagudo, Stephen P. Saville, Jose L. Lopez-Ribot, Anna L. Lazzell

The opportunistic fungal pathogen Candida albicans is an increasingly common threat to human health . Candida albicans grows in several morphologies and mutant strains locked in yeast or filamentous forms have attenuated virulence in the murine model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5e6da5488dd7872f2cd3892ee86725
https://europepmc.org/articles/PMC5006252/

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BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence

Autor: Anna L. Lazzell, Derek P. Thomas, Ian A. Cleary, Carlos Monteagudo, Stephen P. Saville

Publikováno v: Molecular Microbiology. 85:557-573

In the opportunistic fungal pathogen Candida albicans both cellular morphology and the capacity to cause disease are regulated by the transcriptional repressor Nrg1p. One of the genes repressed by Nrg1p is BRG1, which encodes a putative GATA family t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8124f66f68e912957986591e2dda08e
https://doi.org/10.1111/j.1365-2958.2012.08127.x

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Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis

Autor: Margarida Isabel Barros Coelho Martins, Jose L. Lopez-Ribot, Mariana Henriques, Rosário Oliveira, Anna L. Lazzell

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Candida albicans supernatants contain a mixture of autoregulatory alcohols. In vitro, when added individually or in combination, these alcohols inhibit the yeast to filamentous form conversion. Here we evaluate the in vivo effect of the exogenous adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f5a8194fc3796bad7084058f431093
https://doi.org/10.1002/jobm.201100158

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Pseudohyphal Regulation by the Transcription Factor Rfg1p in Candida albicans

Autor: Priyadarshini Mulabagal, Martin H. Thornhill, Carlos Monteagudo, Stephen P. Saville, Anna L. Lazzell, Derek P. Thomas, Nishant P. Yadev, Craig Murdoch, Sara M. Reinhard, Ian A. Cleary

Publikováno v: Eukaryotic Cell. 9:1363-1373

The opportunistic human fungal pathogen Candida albicans is a major cause of nosocomial infections. One of the fundamental features of C. albicans pathogenesis is the yeast-to-hypha transition. Hypha formation is controlled positively by transcriptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f1b64b82c256536fa10e746f9b068d
https://doi.org/10.1128/ec.00088-10

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Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence

Autor: David Kadosh, Anna L. Lazzell, Patricia L. Carlisle, Carlos Monteagudo, Mohua Banerjee, Jose L. Lopez-Ribot

Publikováno v: Proceedings of the National Academy of Sciences. 106:599-604

Candida albicans , the major human fungal pathogen, undergoes a reversible morphological transition from single yeast cells to pseudohyphal and hyphal filaments (elongated cells attached end-to-end). Because typical C. albicans infections contain a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d472428a35a7dd32e3e4afad1e01872
https://doi.org/10.1073/pnas.0804061106

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Candida albicans VPS4 is Required for Secretion of Aspartyl Proteases and In Vivo Virulence

Autor: Jason Jones, Carlos Monteagudo, Anna L. Lazzell, Jose L. Lopez-Ribot, Stella M. Bernardo, Samuel A. Lee, Zachary Khalique, Sarah E. Hardison, John Kot

Publikováno v: Mycopathologia. 167:55-63

Candida albicans secretes aspartyl proteases (Saps) during infection. Although Saps are secretory proteins, little is known about the intracellular trafficking and secretion of these proteins. We previously cloned and analyzed the C. albicans pre-vac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7286af9253d4518af915996ffc7480eb
https://doi.org/10.1007/s11046-008-9155-7

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