Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Anna L Gharibyan"'
Autor:
Kristoffer Brännström, Malin Lindhagen-Persson, Anna L Gharibyan, Irina Iakovleva, Monika Vestling, Mikael E Sellin, Thomas Brännström, Ludmilla Morozova-Roche, Lars Forsgren, Anders Olofsson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90857 (2014)
Antibodies that preferentially and specifically target pathological oligomeric protein and peptide assemblies, as opposed to their monomeric and amyloid counterparts, provide therapeutic and diagnostic opportunities for protein misfolding diseases. U
Externí odkaz:
https://doaj.org/article/85bdb2aa8c704054b936e00b43b5987b
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 446 (2022)
Amyloid formation is a pathological process associated with a wide range of degenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and diabetes mellitus type 2. During disease progression, abnormal accumulation and deposition
Externí odkaz:
https://doaj.org/article/7703cc0dc6d1447a8bfe02d82a32ec87
Autor:
Kristoffer Bra¨nnstro¨m, Anna L. Gharibyan, Tohidul Islam, Irina Iakovleva, Lina Nilsson, Cheng Choo Lee, Linda Sandblad, Annelie Pamren, Anders Olofsson
Publikováno v:
Data in Brief, Vol 19, Iss , Pp 1166-1170 (2018)
We demonstrate the use of Scanning Electron microscopy (SEM) in combination with Surface Plasmon Resonance (SPR) to probe and verify the formation of amyloid and its morphology on an SPR chip. SPR is a technique that measures changes in the immobiliz
Externí odkaz:
https://doaj.org/article/90a9b1aa80134fd194620775d37cad71
Autor:
Anna L. Gharibyan, Tohidul Islam, Nina Pettersson, Solmaz A. Golchin, Johanna Lundgren, Gabriella Johansson, Mélany Genot, Nina Schultz, Malin Wennström, Anders Olofsson
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 134 (2020)
Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease. ApoE is commonly found in amyloid dep
Externí odkaz:
https://doaj.org/article/a377a8f0404d46d5aff4a307805b4139
Autor:
Fredrik Almqvist, Souvik Sarkar, Anders Olofsson, Mohit Tyagi, Pardeep Singh, Jaideep B. Bharate, Jörgen Ådén, Dan E. Adolfsson, Anna L. Gharibyan, Sanduni Wasana Jayaweera, Anita Kiss
Publikováno v:
The Journal of Organic Chemistry
Reaction of thiazoline fused 2-pyridones with alkyl halides in the presence of cesium carbonate opens the thiazoline ring via S-alkylation and generates N-alkenyl functionalized 2-pyridones. In the reaction with propargyl bromide, the thiazoline ring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2067b1552fb6c2e0fef22c5f8d64dc10
http://europepmc.org/articles/PMC8650012
http://europepmc.org/articles/PMC8650012
Autor:
Jörgen Ådén, Pardeep Singh, Mohit Tyagi, Sanduni Wasana Jayaweera, Anders Olofsson, Adrian Deuschmann, Fredrik Almqvist, Anna L. Gharibyan, Anders E. G. Lindgren, Dan E. Adolfsson
Publikováno v:
The Journal of Organic Chemistry
A BF3×OEt2 catalyzed intramolecular Povarov reaction was used to synthesize a library of 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with a range of O-alkylated salicylaldehydes and amino functionalized thiazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc585e0880abcb5117ac3b4539093182
https://doi.org/10.1021/acs.joc.0c01699
https://doi.org/10.1021/acs.joc.0c01699
Autor:
Nina Pettersson, Intissar Anan, Lovisa Lettius, Anna L. Gharibyan, Anders Olofsson, Elvira Oskarsson, Sanduni Wasana Jayaweera, Solmaz Surano
Publikováno v:
Biomolecules
Volume 11
Issue 3
Biomolecules, Vol 11, Iss 411, p 411 (2021)
Volume 11
Issue 3
Biomolecules, Vol 11, Iss 411, p 411 (2021)
Amyloid-formation by the islet amyloid polypeptide (IAPP), produced by the β-cells in the human pancreas, has been associated with the development of type II diabetes mellitus (T2DM). The human plasma-protein transthyretin (TTR), a well-known amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d7291b3f5e49539a3f3374fd3b4909
Autor:
Pardeep Singh, Jörgen Ådén, Anders Olofsson, Mohit Tyagi, Mari Bonde, Sanduni Wasana Jayaweera, Fredrik Almqvist, Sven Bergström, Dan E. Adolfsson, Katarina Vielfort, Jaideep B. Bharate, Anna L. Gharibyan
We herein present the synthesis of diversely functionalized pyrimidine fused thiazolino-2-pyridones via K2S2O8-mediated oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-2-pyridones with aldehydes. The developed protocol is mild, has wide subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63335de81707c7bc93f57449c42e827d
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189516
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189516
Autor:
Tohidul Islam, Malin Wennström, Nina Schultz, Solmaz A. Golchin, Anna L. Gharibyan, Mélany Genot, Nina Pettersson, Gabriella Johansson, Johanna Lundgren, Anders Olofsson
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 1, p 134 (2020)
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 134 (2020)
Volume 10
Issue 1
Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer&rsquo
s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease. ApoE is commonly found in am
s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease. ApoE is commonly found in am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6f2f3762cafd23ddd4044f3efad13b
http://europepmc.org/articles/PMC7022431
http://europepmc.org/articles/PMC7022431
Autor:
Tohidul Islam, Irina Iakovleva, Linda Sandblad, Anders Olofsson, Solmaz A. Golchin, Nina Pettersson, Lina Nilsson, Anna L. Gharibyan, Annelie Pamrén, Kristoffer Brännström
Publikováno v:
Journal of Molecular Biology. 430:2722-2733
The pathological Aβ aggregates associated with Alzheimer's disease follow a nucleation-dependent path of formation. A nucleus represents an oligomeric assembly of Aβ peptides that acts as a template for subsequent incorporation of monomers to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae7de984e5f22b0dfd48ee275f6c6c3
https://doi.org/10.1016/j.jmb.2018.06.005
https://doi.org/10.1016/j.jmb.2018.06.005