Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Anna L, Duncan"'
Autor:
T. Bertie Ansell, Wanling Song, Claire E. Coupland, Loic Carrique, Robin A. Corey, Anna L. Duncan, C. Keith Cassidy, Maxwell M. G. Geurts, Tim Rasmussen, Andrew B. Ward, Christian Siebold, Phillip J. Stansfeld, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution
Externí odkaz:
https://doaj.org/article/cf3afb5f6f044bce9bcb06b11105b64c
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Voltage-gated sodium (Nav) channels form the basis for the initiation of the action potential in excitable cells by allowing sodium ions to pass through the cell membrane. The Nav channel α subunit is known to function both with and without associat
Externí odkaz:
https://doaj.org/article/35af817657a44041b2ae713f45bcc26d
Autor:
Yagmur Azbazdar, Ozgun Ozalp, Erdinc Sezgin, Sapthaswaran Veerapathiran, Anna L. Duncan, Mark S. P. Sansom, Christian Eggeling, Thorsten Wohland, Ezgi Karaca, Gunes Ozhan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
While the lateral organization of plasma membrane components has been shown to control binding of Wnt ligands to their receptors preferentially in the ordered membrane domains, the role of posttranslational lipid modification of Wnt on this selective
Externí odkaz:
https://doaj.org/article/a9724d169876401287684486b7187c3e
Autor:
Matthieu Chavent, Anna L. Duncan, Patrice Rassam, Oliver Birkholz, Jean Hélie, Tyler Reddy, Dmitry Beliaev, Ben Hambly, Jacob Piehler, Colin Kleanthous, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
In Escherichia coli, outer membrane protein (OMP) cluster and form islands, but the origin and behaviour of those clusters remains poorly understood. Here authors use coarse grained molecular dynamics simulation and show that their mesoscale simulati
Externí odkaz:
https://doaj.org/article/19638c51dad4423f8b459af3fd0c85a4
Autor:
Aniruddha Panda, Fabian Giska, Anna L. Duncan, Alexander J. Welch, Caroline Brown, Rachel McAllister, Parameswaran Hariharan, Jean N. D. Goder, Jeff Coleman, Sathish Ramakrishnan, Frédéric Pincet, Lan Guan, Shyam Krishnakumar, James E. Rothman, Kallol Gupta
Publikováno v:
Panda, A, Giska, F, Duncan, A L, Welch, A J, Brown, C, McAllister, R, Hariharan, P, Goder, J N D, Coleman, J, Ramakrishnan, S, Pincet, F, Guan, L, Krishnakumar, S, Rothman, J E & Gupta, K 2023, ' Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer ', Nature Methods, vol. 20, no. 6, pp. 891-897 . https://doi.org/10.1038/s41592-023-01864-5
Hierarchical organization of integral membrane proteins (IMP) and lipids at the membrane is essential for regulating myriad downstream signaling. A quantitative understanding of these processes requires both detections of oligomeric organization of I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32353ac527de672db3b090c2e035a260
https://doi.org/10.1101/2023.03.12.532274
https://doi.org/10.1101/2023.03.12.532274
Autor:
Anna L. Duncan, Weria Pezeshkian
Publikováno v:
Duncan, A L & Pezeshkian, W 2023, ' Mesoscale simulations : An indispensable approach to understand biomembranes ', Biophysical Journal, vol. 122, no. 11, pp. 1883-1889 . https://doi.org/10.1016/j.bpj.2023.02.017
Computer simulation techniques form a versatile tool, a computational microscope, for exploring biological processes. This tool has been particularly effective in exploring different features of biological membranes. In recent years, thanks to elegan
Publikováno v:
Chemical science. 13(45)
The mitochondrial electron transport chain comprises a series of protein complexes embedded in the inner mitochondrial membrane that generate a proton motive force via oxidative phosphorylation, ultimately generating ATP. These protein complexes can
Autor:
T. Bertie Ansell, Wanling Song, Claire E. Coupland, Loic Carrique, Robin A. Corey, Anna L. Duncan, C. Keith Cassidy, Maxwell M. G. Geurts, Tim Rasmussen, Andrew B. Ward, Christian Siebold, Phillip J. Stansfeld, Mark S. P. Sansom
Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution of lipid-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::665d5bdf78e805f664f9513693413ad8
https://doi.org/10.1101/2022.06.30.498233
https://doi.org/10.1101/2022.06.30.498233
Publikováno v:
Microbiology. 168
Bacterial cell envelopes are compositionally complex and crowded and while highly dynamic in some areas, their molecular motion is very limited, to the point of being almost static in others. Therefore, it is no real surprise that studying them at hi
Autor:
Wanling Song, Robin A. Corey, T. Bertie Ansell, C. Keith Cassidy, Michael R. Horrell, Anna L. Duncan, Phillip J. Stansfeld, Mark S. P. Sansom
Publikováno v:
Journal of chemical theory and computation. 18(2)
Lipids play important modulatory and structural roles for membrane proteins. Molecular dynamics simulations are frequently used to provide insights into the nature of these protein-lipid interactions. Systematic comparative analysis requires tools th