Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Anna Kuchnio"'
Autor:
Juan R. Hernandez-Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J. Neilson, Ellie Pulleine, Alice Santi, Shehab Ismail, Sergio Lilla, Sandeep Dhayade, Iain R. MacPherson, Iain McNeish, Darren Ennis, Hala Ali, Fernanda G. Kugeratski, Heba Al Khamici, Maartje van den Biggelaar, Peter V.E. van den Berghe, Catherine Cloix, Laura McDonald, David Millan, Aoisha Hoyle, Anna Kuchnio, Peter Carmeliet, Stella M. Valenzuela, Karen Blyth, Huabing Yin, Massimiliano Mazzone, Jim C. Norman, Sara Zanivan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibr
Externí odkaz:
https://doaj.org/article/95c1f45d24284070873d0d702ce64647
Autor:
Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem, Anna Rita Cantelmo, Lena-Christin Conradi, Saar Vandekeere, Ann Bouché, Ivo Cornelissen, Stefan Vinckier, Roeland M. H. Merks, Elisabetta Dejana, Holger Gerhardt, Mieke Dewerchin, Katie Bentley, Peter Carmeliet
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing interce
Externí odkaz:
https://doaj.org/article/f168b79c697d4569b921c383b7c0a3c0
Autor:
Anna Kuchnio, Stijn Moens, Ulrike Bruning, Karol Kuchnio, Bert Cruys, Bernard Thienpont, Michaël Broux, Andreea Alexandra Ungureanu, Rodrigo Leite de Oliveira, Françoise Bruyère, Henar Cuervo, Ann Manderveld, An Carton, Juan Ramon Hernandez-Fernaud, Sara Zanivan, Carmen Bartic, Jean-Michel Foidart, Agnes Noel, Stefan Vinckier, Diether Lambrechts, Mieke Dewerchin, Massimiliano Mazzone, Peter Carmeliet
Publikováno v:
Cell Reports, Vol 12, Iss 6, Pp 992-1005 (2015)
Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed. First, the role of PHD2 in metastasis has not been studied in a spontaneous tumor model. Here, we show that global PHD2 haplodeficien
Externí odkaz:
https://doaj.org/article/84a2f84782c44a938ff33527b7a39ea2
Autor:
Florent Morfoisse, Anna Kuchnio, Clement Frainay, Anne Gomez-Brouchet, Marie-Bernadette Delisle, Stefano Marzi, Anne-Catherine Helfer, Fransky Hantelys, Francoise Pujol, Julie Guillermet-Guibert, Corinne Bousquet, Mieke Dewerchin, Stephane Pyronnet, Anne-Catherine Prats, Peter Carmeliet, Barbara Garmy-Susini
Publikováno v:
Cell Reports, Vol 6, Iss 1, Pp 155-167 (2014)
Various tumors metastasize via lymph vessels and lymph nodes to distant organs. Even though tumors are hypoxic, the mechanisms of how hypoxia regulates lymphangiogenesis remain poorly characterized. Here, we show that hypoxia reduced vascular endothe
Externí odkaz:
https://doaj.org/article/beaa0b48d095499fbd02c37c1b384aaf
Autor:
Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D. Gareth Evans, Peter Carmeliet, Massimiliano Mazzone, Claudia Bagni
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 10, Pp 1523-1536 (2013)
Abstract The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, i
Externí odkaz:
https://doaj.org/article/59f66fcd6c5a494980012c04e212b710
Autor:
Maria Gdaniec, Jarosław Sączewski, Karolina Lisewska, Agnieszka Kiedrowska, Marta Łobocka, Monika Samsel, Anna Kuchnio, Franciszek Sączewski, Patrick J. Bednarski
Publikováno v:
Molecules, Vol 15, Iss 3, Pp 1113-1126 (2010)
The course of reaction of aryl and heteroaryl sulfonamides with diphenylcarbonate (DPC) and 4-dimethylaminopyridine (DMAP) was found to depend on the pKa of the sulfonamide used. Aryl sulfonamides with pKa ~ 10 gave 4-dimethylamino-pyridinium arylsul
Externí odkaz:
https://doaj.org/article/16dec54163c5414d86f5ac752794aa7b
Autor:
Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D Gareth Evans, Peter Carmeliet, Massimiliano Mazzone, Claudia Bagni
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 4, Pp 567-568 (2014)
Externí odkaz:
https://doaj.org/article/6867d17cff864898af188da64ab4d5db
Autor:
Anna Kuchnio, Danlin Yang, Nele Vloemans, Cassandra Lowenstein, Ivo Cornelissen, Ricardo Amorim, Chao Han, Siddharth Sukumaran, Lut Janssen, Toon Suls, Mariette Bekkers, Elena Lasorsa, Lorena Fontana, Nicole Medeiros, Bingyuan Wu, Jun Chen, Michael Feldkamp, Sheng-Jiun Wu, Habtom Habte, John Krayer, Cam Holland, M. Phillip Deyoung, Yusri A Elsayed, Ulrike Philippar
Publikováno v:
Blood. 140:3105-3106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1400068381b3f118949b0557ac22f5fa
https://doi.org/10.1182/blood-2022-168739
https://doi.org/10.1182/blood-2022-168739
Autor:
Jermaine Goveia, Ton J. Rabelink, Lena Christin Conradi, Bram Boeckx, Bart Ghesquière, Pallavi Chaturvedi, Joanna Kalucka, Kim R. Kampen, Lucas Treps, Diether Lambrechts, Francesco Bifari, Koen Veys, Guy Eelen, Asrar B. Malik, Johanna Hol, Bert Cruys, Jalees Rehman, Joris Vriens, Tor Espen Stav-Noraas, Sandra Schoors, Luc Schoonjans, Katrien De Bock, Guttorm Haraldsen, Laure Anne Teuwen, Andreas Pircher, Anna Kuchnio, Aleksandra Brajic, Peter Carmeliet, Anna Rita Cantelmo, Peter C. Stapor, Lise Finotto, Mieke Dewerchin, Bernard Thienpont, Ilaria Decimo
Publikováno v:
Cancer Cell, 30(6), 968-985
Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as an anti-cancer treatment. Here, we show that tumor endothelial cells (ECs) have a hyperglycolytic metabolism, shunting intermedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c09a7524dbfa29f31a1da1ac32cffa
https://doi.org/10.1016/j.ccell.2016.10.006
https://doi.org/10.1016/j.ccell.2016.10.006
Autor:
Saar Vandekeere, Brian W. Wong, Stefan Vinckier, Elisabetta Dejana, Peter Carmeliet, Holger Gerhardt, Anna Rita Cantelmo, Anna Kuchnio, Lena Christin Conradi, Ann Bouché, Mieke Dewerchin, Roeland M. H. Merks, Katie Bentley, Bert Cruys, Ivo Cornelissen, Dries Verdegem
Publikováno v:
Nature Communications
Nature Communications, 7
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Cruys, B, Wong, B W, Kuchnio, A, Verdegem, D, Cantelmo, A R, Conradi, L C, Vandekeere, S, Bouche, A, Cornelissen, I, Vinckier, S, Merks, R M H, Dejana, E, Gerhardt, H, Dewerchin, M, Bentley, K & Carmeliet, P 2016, ' Glycolytic regulation of cell rearrangement in angiogenesis ', Nature Communications, vol. 7, 12240, pp. 1-15 . https://doi.org/10.1038/ncomms12240
Nature Communications, 7, 12240. Nature Research
Nature Communications, 7
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Cruys, B, Wong, B W, Kuchnio, A, Verdegem, D, Cantelmo, A R, Conradi, L C, Vandekeere, S, Bouche, A, Cornelissen, I, Vinckier, S, Merks, R M H, Dejana, E, Gerhardt, H, Dewerchin, M, Bentley, K & Carmeliet, P 2016, ' Glycolytic regulation of cell rearrangement in angiogenesis ', Nature Communications, vol. 7, 12240, pp. 1-15 . https://doi.org/10.1038/ncomms12240
Nature Communications, 7, 12240. Nature Research
During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip position. We recently identified a key role for the glycolytic activator PFKFB3 in vessel sprouting by regulating cytoskeleton remod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442049ab968786f0578b091ccd06c573
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302709
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302709