Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anna Kopp"'
Autor:
Anna Kopp, Hyeyoung Kwon, Colette Johnston, Steven Vance, James Legg, Laurie Galson-Holt, Greg M. Thurber
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 48, Iss , Pp 100962- (2024)
Bispecific agents are a rapidly growing class of cancer therapeutics, and immune targeted bispecific agents have the potential to expand functionality well beyond monoclonal antibody agents. Humabodies⁎⁎ Humabody® is a registered trademark of Cr
Externí odkaz:
https://doaj.org/article/e10bbca475e14f86ac0602ed0855f6fb
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Eshita Khera, Cornelius Cilliers, Michael D. Smith, Michelle L. Ganno, Katharine C. Lai, Thomas A. Keating, Anna Kopp, Ian Nessler, Adnan O. Abu-Yousif, Greg M. Thurber
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Externí odkaz:
https://doaj.org/article/a1d49a829b1446a5941d3e371fc652ef
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Preclinical in vivo studies form the cornerstone of drug development and translation, bridging in vitro experiments with first-in-human trials. However, despite the utility of animal models, translation from the bench to bedside remains difficult, pa
Externí odkaz:
https://doaj.org/article/f28851479b384140a9613e2d68f6e4dc
Autor:
Greg M. Thurber, Jennifer Donnell, Serengulam V. Govindan, Thomas M. Cardillo, Scott Hofsess, Anna Kopp
Supplemental Figures S1-S8, supplemental methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea83891ec2a4e25c01f80f9d1732615
https://doi.org/10.1158/1535-7163.22523199.v1
https://doi.org/10.1158/1535-7163.22523199.v1
Autor:
Greg M. Thurber, Normann Goodwin, Lorraine Thompson, James Legg, Thomas Sandal, Adnan O. Abu-Yousif, Thomas A. Keating, Qifeng Qiu, Anna Kopp, Steven Vance, Eshita Khera, Ian Nessler
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA-approved antibody–drug conjugates (ADC). However, a variety of pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb7ab2805dd13cdbb4ee95f79492b5
https://doi.org/10.1158/0008-5472.c.6511984.v1
https://doi.org/10.1158/0008-5472.c.6511984.v1
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Katharine C. Lai, Michael D. Smith, Ian Nessler, Anna Kopp, Cornelius Cilliers, Thomas A. Keating, Adnan O. Abu-Yousif, Greg M. Thurber, Michelle L. Ganno, Eshita Khera
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303ee4292d185874883a1e4516940339
https://doi.org/10.1016/j.neo.2020.12.001
https://doi.org/10.1016/j.neo.2020.12.001
Autor:
Anna Kopp, Scott Hofsess, Thomas M. Cardillo, Serengulam V. Govindan, Jennifer Donnell, Greg M. Thurber
Publikováno v:
Molecular cancer therapeutics. 22(1)
Antibody–drug conjugates (ADC) are a rapidly growing class of targeted cancer treatments, but the field has experienced significant challenges from their complex design. This study examined the multiscale distribution of sacituzumab govitecan (SG;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d7aef9ac22ca8e6888ce4c8f3f574f
https://pubmed.ncbi.nlm.nih.gov/36190986
https://pubmed.ncbi.nlm.nih.gov/36190986
Autor:
Thomas Sandal, Ian Nessler, Steven Vance, Thomas A. Keating, Anna Kopp, Lorraine Thompson, Eshita Khera, Adnan O. Abu-Yousif, Qifeng Qiu, Greg M. Thurber, Normann Goodwin, James Legg
Publikováno v:
Cancer Research. 80:1268-1278
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA-approved antibody–drug conjugates (ADC). However, a variety of pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8f338667a5db5f2954b8cbbd436a79
https://doi.org/10.1158/0008-5472.can-19-2295
https://doi.org/10.1158/0008-5472.can-19-2295
Autor:
Greg M. Thurber, Anna Kopp
Publikováno v:
Cell Chemical Biology. 26:1631-1633
As a key mediator of efficacy and toxicity, the linker connecting the payload in antibody drug conjugates determines cellular distribution and payload release. Sorkin et al. (2019) have created novel fluorescence-based linkers to quantify the rate of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05159ff9dedd3d551767eb959159eb38
https://doi.org/10.1016/j.chembiol.2019.12.001
https://doi.org/10.1016/j.chembiol.2019.12.001
Autor:
Anna Koppin, Leah Chase
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10271 (2024)
System xc−, the cystine/glutamate exchanger, is a membrane transporter that plays a critical role in the antioxidant response of cells. Recent work has shown that System xc− localizes to the plasma membrane during oxidative stress, allowing for i
Externí odkaz:
https://doaj.org/article/f1818c19dc3d4c888bc7cf5a81dc848b