Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Anna Koloteva"'
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Akademický článek
Analysis of pulmonary vascular injury and repair during infection-induced pneumonia and acute respiratory distress syndrome
Autor: Ashley S. Lindsey, Lydia M. Sullivan, Nicole A. Housley, Anna Koloteva, Judy A. King, Jonathon P. Audia, Diego F. Alvarez
Publikováno v: Pulmonary Circulation, Vol 9 (2019)
Herein we describe lung vascular injury and repair using a rodent model of Pseudomonas aeruginosa pneumonia-induced acute respiratory distress syndrome (ARDS) during: 1) the exudative phase (48-hour survivors) and 2) the reparative/fibro-proliferativ
Externí odkaz: https://doaj.org/article/d51f1d9dcaed405abf5a75226289445a
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5
Ablation of PDE4B protects from Pseudomonas aeruginosa‐induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia
Autor: Abigail Boyd, Ileana V. Aragon, Wito Richter, Wadad Mneimneh, Robert A. Barrington, Anna Koloteva, Domenico Spadafora, Lina Abou Saleh
Publikováno v: FASEB J
Pseudomonas aeruginosa is a frequent cause of hospital-acquired lung infections characterized by hyperinflammation, antibiotic resistance, and high morbidity/mortality. Here, we show that the genetic ablation of one cAMP-phosphodiesterase 4 subtype,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37932d48d9175b2bc468073cc849ec48
https://doi.org/10.1096/fj.202100495r
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6
Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy
Autor: Chung-Sik Choi, Meredith Gwin, Sarah Voth, Claire Kolb, Chun Zhou, Amy R. Nelson, Althea deWeever, Anna Koloteva, Naga S. Annamdevula, James M. Murphy, Brant M. Wagener, Jean-Francois Pittet, Ssang-Taek S. Lim, Ron Balczon, Troy Stevens, Mike T. Lin
Publikováno v: The Journal of Biological Chemistry
Patients who recover from nosocomial pneumonia oftentimes exhibit long-lasting cognitive impairment comparable with what is observed in Alzheimer’s disease patients. We previously hypothesized that the lung endothelium contributes to infection-rela
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6871903b884d5aad142c120684cb3b12
https://pubmed.ncbi.nlm.nih.gov/34896150
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7
Pneumonia initiates a tauopathy
Autor: Jean-Francois Pittet, Phoibe Renema, Mike T. Lin, Jessica Bell, Troy Stevens, Brant M. Wagener, Corey E. Ventetuolo, Ron Balczon, C Michael Francis, Chung-Sik Choi, Chun Zhou, Neel R. Sodha, S.B. Voth, Ji Young Lee, Anna Koloteva, Adeel Abbasi
Publikováno v: The FASEB Journal
Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8693e0cb477a7f85b5fd06ae550f862
https://pubmed.ncbi.nlm.nih.gov/34384141
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9
Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice
Autor: Will McDonough, Justin Rich, Ileana V. Aragon, Wito Richter, Lina Abou Saleh, Abigail Boyd, Anna Koloteva
Publikováno v: Biochem Pharmacol
Despite major advances, there remains a need for novel anesthetic drugs or drug combinations with improved efficacy and safety profiles. Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4), while not inducing anesthesia by itself, potent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec796406741d1f0bb0cd20438b3854a
https://pubmed.ncbi.nlm.nih.gov/33609559
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10
KD025 Shifts Pulmonary Endothelial Cell Bioenergetics and Decreases Baseline Lung Permeability
Autor: Mary Kash, Ji Young Lee, Anna Koloteva, Reece P. Stevens, Sunita Subedi Paudel, Phoibe Renema, Chun Zhou, Troy Stevens
Publikováno v: Am J Respir Cell Mol Biol
KD025 is a ROCK2 inhibitor currently being tested in clinical trials for the treatment of fibrotic lung diseases. The therapeutic effects of KD025 are partly due to its inhibition of profibrotic pathways and fat metabolism. However, whether KD025 aff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1edb169ac1e6c6fa34590b53bc6d1e
https://europepmc.org/articles/PMC7528923/
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