Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anna Knörlein"'
Autor:
Anna Knörlein, Chris P. Sarnowski, Tebbe de Vries, Moritz Stoltz, Michael Götze, Ruedi Aebersold, Frédéric H.-T. Allain, Alexander Leitner, Jonathan Hall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Although UV-induced cross-linking is a widely used method to study RNA-protein complexes, the cross-linking reactions are poorly understood. Here, the authors show that π-stacking interactions between nucleobases and aromatic amino acids play a key
Externí odkaz:
https://doaj.org/article/2cd6d485f0bf4ae2b1dfd7988cfbb5cd
Publikováno v:
Trends in Cancer. 9:410-420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2723d94e0d8aaf8aba7e89ae8ba89bbd
https://doi.org/10.1016/j.trecan.2023.01.005
https://doi.org/10.1016/j.trecan.2023.01.005
Autor:
Alexander Leitner, Frédéric H.-T. Allain, Michael Götze, Anna Knörlein, Jonathan Hall, Chris P. Sarnowski, Ruedi Aebersold, Tebbe de Vries
Publikováno v:
Analytical Chemistry, 93 (44)
Analytical Chemistry
Analytical Chemistry
RNA-protein interactions mediate many intracellular processes. CLIR-MS (cross-linking of isotope-labeled RNA and tandem mass spectrometry) allows the identification of RNA-protein interaction sites at single nucleotide/amino acid resolution in a sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314722c2c94a34871c12f73c42de553f
https://doi.org/10.1021/acs.analchem.1c02384
https://doi.org/10.1021/acs.analchem.1c02384
Autor:
Ruedi Aebersold, Tebbe de Vries, Anna Knörlein, Jonathan Hall, Alexander Leitner, Frédéric H.-T. Allain, Moritz Stoltz, Chris P. Sarnowski, Michael Götze
Understanding structure-function relationships of RNA-binding proteins requires knowledge of how they bind RNAs in vivo. RNA-protein interactions are studied using light-induced cross-linking at “zero-distance”, yielding nucleotide/amino-acid add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8eb9446c60573010d39ab422b135e32
https://doi.org/10.26434/chemrxiv-2021-05zhj
https://doi.org/10.26434/chemrxiv-2021-05zhj
Autor:
Anna Knörlein, Michael Krug, Andreas Heine, Ah Young Park, Karine Röwer, Uwe Mueller, Franziska U. Huschmann, S.G. Krimmer, J. Schiebel, Manfred S. Weiss, F.R. Ehrmann, Kan Fu, Xiaojie Wang, Steffen Glöckner, Gerhard Klebe, Martin Stieler, Nedyalka Radeva
Publikováno v:
Structure. 24:1398-1409
Today the identification of lead structures for drug development often starts from small fragment-like molecules raising the chances to find compounds that successfully pass clinical trials. At the heart of the screening for fragments binding to a sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcbc5f8cdb2c09286bebfea9484cf3c
https://doi.org/10.1016/j.str.2016.06.010
https://doi.org/10.1016/j.str.2016.06.010
Autor:
Andreas Heine, Anna Knörlein, Sebastian Martin Saupe, Stefan Hinkes, Teodora Ivanova, André Wuttke, Torsten Steinmetzer, Sebastian Wagner, Gerhard Klebe
Publikováno v:
Journal of Medicinal Chemistry. 59:6370-6386
New macrocyclic plasmin inhibitors based on our previously optimized P2-P3 core segment have been developed. In the first series, the P4 residue was modified, whereas the 4-amidinobenzylamide in P1 position was maintained. The originally used P4 benz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067dfbcf5d42ff3a7e42f0d8fd7d6f54
https://doi.org/10.1021/acs.jmedchem.6b00606
https://doi.org/10.1021/acs.jmedchem.6b00606
Autor:
Anna Knörlein, Jonathan Hall, Hasane Ratni, Simon H Rüdisser, Sarah Boigner, Laurent Gillioz, Antoine Cléry, Ahmed Moursy, Sébastien Campagne, Frédéric H.-T. Allain
Publikováno v:
Nature chemical biology. 15(12)
Splicing modifiers promoting SMN2 exon 7 inclusion have the potential to treat spinal muscular atrophy, the leading genetic cause of infantile death. These small molecules are SMN2 exon 7 selective and act during the early stages of spliceosome assem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99220204e40139921b99acdc27df167
https://pubmed.ncbi.nlm.nih.gov/31636429
https://pubmed.ncbi.nlm.nih.gov/31636429