Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anna Ketola"'
Autor:
Ari Hinkkanen, Ann-Marie Määttä, Riikka Pellinen, Anna Ketola, Marko Björn, Kimmo Mäkinen, Petra T. Furu, Timo Liimatainen, Tanja Hakkarainen, Jarmo Wahlfors, Risto Pirinen, Felicitas Yongabi
Publikováno v:
Cancer Research. 68:8342-8350
Oncolytic viruses are a promising tool for treatment of cancer. We studied an oncolytic Semliki Forest virus (SFV) vector, VA7, carrying the enhanced green fluorescent protein gene (EGFP), as a novel virotherapy candidate against unresectable osteosa
Autor:
Ann-Marie Määttä, Riikka Pellinen, Jarmo Wahlfors, Outi Rautsi, Anna Ketola, Kimmo Mäkinen, Markus Vähä-Koskela, Timo Liimatainen, Risto Pirinen, Ari Hinkkanen, Felicitas Yongabi
Publikováno v:
International journal of cancer. 123(7)
We evaluated the therapeutic potential of the replication competent vector VA7-EGFP, which is based on the avirulent Semliki Forest virus (SFV) strain A7 (74) carrying the EGFP marker gene in an orthotopic lung cancer tumor model in nude mice. We hav
Autor:
Jarmo Wahlfors, Outi Rautsi, Ann-Marie Määttä, Riikka Pellinen, Saara Lehmusvaara, Anna Ketola
Publikováno v:
Cancer gene therapy. 15(5)
Cancer suicide gene therapy based on herpes simplex virus type I thymidine kinase (HSV-TK) and ganciclovir (GCV) suffers from the lack of efficacy in clinical use, which is mostly due to low gene-transfer efficiency and absence of bystander effect in
Publikováno v:
International Journal of Molecular Medicine.
We have evaluated a chimeric, two-component Sindbis virus packaging system. As expected, use of this combination of two modified helper RNA species prevented formation of infection competent Sindbis viruses as analyzed by serial passaging. We observe
Autor:
Tiina Wahlfors, Jarmo Wahlfors, Anni Tenhunen, Anna Ketola, Riikka Pellinen, Tuula Salonen, Tanja Hakkarainen, Kirsi Tulimäki
Publikováno v:
International Journal of Oncology.
Lentiviruses have been used as gene transfer vectors for almost 10 years and their utility has been demonstrated in a variety of different applications. However, their value in cancer gene therapy has not been studied thoroughly. Here we show that VS
Publikováno v:
International journal of molecular medicine. 13(5)
Osteosarcoma and chondrosarcoma, the most prevalent primary malignant tumors of the bone, have been demonstrated to be potential target diseases for herpes simplex virus type 1 thymidine kinase (HSV-TK)/ganciclovir (GCV) suicide gene therapy. However
Publikováno v:
Molecular Therapy. 11:S329
Top of pageAbstract We have evaluated a chimeric, two-component Sindbis virus packaging system (Frolov et al, 1997, J. Virol. 71, 2819-2829). As expected, use of this combination of two modified helper RNA species prevented formation of infection com
Autor:
Kirsi Tulimäki, Anni Tenhunen, Riikka Pellinen, Tiina Pasanen, Pekka Timonen, Tanja Hakkarainen, Jarmo Wahlfors, Anna Ketola
Publikováno v:
Molecular Therapy. 9:S281
Lentiviral vectors are very efficient gene transfer vehicles for most cell types, regardless of the species or tissue of origin. Several reports suggest that these vectors are efficient for most human tumor cells, but their utility in cancer gene the