Výsledky vyhledávání - "Anna Keppner"

Akademický článek

Ectopic MYBL2-Mediated Regulation of Androglobin Gene Expression

Autor: Antonia Herwig, Carina Osterhof, Anna Keppner, Darko Maric, Teng Wei Koay, Ambre Mbemba-Nsungi, David Hoogewijs

Publikováno v: Cells, Vol 13, Iss 10, p 826 (2024)

Androglobin (ADGB) is a highly conserved and recently identified member of the globin superfamily. Although previous studies revealed a link to ciliogenesis and an involvement in murine spermatogenesis, its physiological function remains mostly unkno

Externí odkaz: https://doaj.org/article/a5cb137200a24bf9b0a5814ad8573552

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Akademický článek

Androglobin, a chimeric mammalian globin, is required for male fertility

Autor: Anna Keppner, Miguel Correia, Sara Santambrogio, Teng Wei Koay, Darko Maric, Carina Osterhof, Denise V Winter, Angèle Clerc, Michael Stumpe, Frédéric Chalmel, Sylvia Dewilde, Alex Odermatt, Dieter Kressler, Thomas Hankeln, Roland H Wenger, David Hoogewijs

Publikováno v: eLife, Vol 11 (2022)

Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa. Whereas hundreds of genes are known to be essential for male germline proliferation and

Externí odkaz: https://doaj.org/article/e692440467a1446e9f1f94e8b46fc3c1

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Akademický článek

Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport

Autor: Anna Keppner, Darko Maric, Miguel Correia, Teng Wei Koay, Ilaria M.C. Orlando, Serge N. Vinogradov, David Hoogewijs

Publikováno v: Redox Biology, Vol 37, Iss , Pp 101687- (2020)

Vertebrate hemoglobin (Hb) and myoglobin (Mb) were among the first proteins whose structures and sequences were determined over 50 years ago. In the subsequent pregenomic period, numerous related proteins came to light in plants, invertebrates and ba

Externí odkaz: https://doaj.org/article/d3876a0400ab456a82f8c935ae3914bf

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Akademický článek

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.

Autor: Anna Keppner, Ditte Andreasen, Anne-Marie Mérillat, Julie Bapst, Camille Ansermet, Qing Wang, Marc Maillard, Sumedha Malsure, Antoine Nobile, Edith Hummler

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135224 (2015)

The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC). To study its in vivo implication in ENaC-mediated sodium absorption, we generated a knockout mous

Externí odkaz: https://doaj.org/article/150db2d379c04a63818ede209b929fa0

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Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCDcl1 Cells

Autor: Hoogewijs, Anna Keppner, Darko Maric, Ilaria Maria Christina Orlando, Laurent Falquet, Edith Hummler, David

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7262

The kidney is strongly dependent on a continuous oxygen supply, and is conversely highly sensitive to hypoxia. Controlled oxygen gradients are essential for renal control of solutes and urine-concentrating mechanisms, which also depend on various hor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::5712a511140c2a9ae814ca3650b9e247

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Androglobin, a chimeric mammalian globin, is required for male fertility

Autor: Roland H. Wenger, Angèle Clerc, Darko Maric, Alex Odermatt, Teng Wei Koay, Frédéric Chalmel, Michael Stumpe, Sylvia Dewilde, Dieter Kressler, Denise V Winter, David Hoogewijs, Anna Keppner, Sara Santambrogio, Thomas Hankeln, Carina Osterhof, Miguel Correia

Publikováno v: eLife
eLife, 2022, 11, pp.e72374. ⟨10.7554/eLife.72374⟩

Spermatogenesis is a highly specialised process, involving multiple dedicated pathways and regulatory check-points. Defects ultimately lead to male sub-fertility or sterility, and numerous aspects of mammalian sperm formation remain unknown. The pred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77932d516943162cdf7efc01c93db251
https://www.zora.uzh.ch/id/eprint/219277/