Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anna Katrin Szardenings"'
Autor:
Chaofeng Huang, Gang Chen, Yingbo He, Anna Katrin Szardenings, Michael A. Letavic, Tamara Berdyyeva, Wei Zhang, Hartmuth C. Kolb, Anindya Bhattacharya, Chunfang Xia, Natalie Taylor
Publikováno v:
Molecular Imaging and Biology. 21:871-878
The P2X7 receptor, an adenosine triphosphate (ATP)-gated purinoreceptor, has emerged as one of the key players in neuroinflammatory processes. Therefore, developing a positron emission tomography (PET) tracer for imaging of P2X7 receptors in vivo pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba7d250b2bcabd043c8d9440586b7f1
https://doi.org/10.1007/s11307-018-01313-2
https://doi.org/10.1007/s11307-018-01313-2
Autor:
Tamara, Berdyyeva, Chunfang, Xia, Natalie, Taylor, Yingbo, He, Gang, Chen, Chaofeng, Huang, Wei, Zhang, Hartmuth, Kolb, Michael, Letavic, Anindya, Bhattacharya, Anna Katrin, Szardenings
Publikováno v:
Molecular imaging and biology. 21(5)
The P2X7 receptor, an adenosine triphosphate (ATP)-gated purinoreceptor, has emerged as one of the key players in neuroinflammatory processes. Therefore, developing a positron emission tomography (PET) tracer for imaging of P2X7 receptors in vivo pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf6c7b87eac51e54ac47181d3a786fd6
https://pubmed.ncbi.nlm.nih.gov/30632003
https://pubmed.ncbi.nlm.nih.gov/30632003
Autor:
Hartmuth C, Kolb, Olivier, Barret, Anindya, Bhattacharya, Gang, Chen, Cristian, Constantinescu, Chaofeng, Huang, Michael, Letavic, Gilles, Tamagnan, Chunfang A, Xia, Wei, Zhang, Anna Katrin, Szardenings
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(8)
The P2X7 receptor is an adenosine triphosphate-gated ion channel, which is abundantly expressed in glial cells within the central nervous system and in the periphery. P2X7 receptor activation leads to the release of the proinflammatory cytokine IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42876fa67e243aa5fef77b4a95431e57
https://pubmed.ncbi.nlm.nih.gov/30733317
https://pubmed.ncbi.nlm.nih.gov/30733317
Autor:
Kevin R. Shreder, Tyzoon K. Nomanbhoy, Ayako Nakamura, Anna Katrin Szardenings, Shigeki Seto, Jonathan S. Rosenblum, Brandon Leen, Oana Cociorva, Kai Nakamura, Bei Li, Marek Liyanage, John W. Kozarich, Qiang Li, Yasushi Kohno, Kazuhiro Yumoto, Kyoko Okada, Masahiro Nomura, Melissa C. Zhang, Arwin Aban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5948-5951
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d9755d781aad544131d0a6c744f45f
https://doi.org/10.1016/j.bmcl.2011.07.073
https://doi.org/10.1016/j.bmcl.2011.07.073
Autor:
Xianfeng Li, Liang Wang, Marc Navre, Christopher P. Holmes, J. Russell Grove, Anna Katrin Szardenings, Larry Jang, Ashok Bhandari, Lihong Shi
Publikováno v:
Tetrahedron Letters. 47:19-22
A new method for the synthesis of functionalized biaryl α-ketophosphonic acids has been developed. The key step involves the use of sodium bromobenzoyl phosphonates to react with polymer-bound boronic acids via microwave-assisted aqueous Suzuki coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::826d53de9c0552daf693fbeda3410ac8
https://doi.org/10.1016/j.tetlet.2005.10.122
https://doi.org/10.1016/j.tetlet.2005.10.122
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4301-4306
A novel series of inhibitors that contain an aryl α,α-difluoro-β-ketophosphonate group has been synthesized and evaluated against protein tyrosine phosphatase 1B. These compounds exhibit strong inhibitory activity, the best of which has a K i valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b19ee09064253b2fc0c3887c0ca293
https://doi.org/10.1016/j.bmcl.2004.05.082
https://doi.org/10.1016/j.bmcl.2004.05.082
Publikováno v:
Tetrahedron. 53:6573-6593
A novel route for the synthesis of diketopiperazines and diketomorpholines on a solid support is described. Two different approaches are reported for diketopiperazines. The cyclization step involves cyclization with simultaneous cleavage from the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa119c3ce54e0d846aa9b54a8d53554
https://doi.org/10.1016/s0040-4020(97)00218-4
https://doi.org/10.1016/s0040-4020(97)00218-4
Publikováno v:
Tetrahedron Letters. 37:3635-3638
A simple and general procedure for preparation of various phosphotyrosine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et3N/CBr4/HP(O)(OEt)2 provides diethyl phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2a3d41bcbaaf65f7c2815786d5d0979
https://doi.org/10.1016/0040-4039(96)00666-1
https://doi.org/10.1016/0040-4039(96)00666-1
Autor:
Tyzoon K. Nomanbhoy, Melissa C. Zhang, Kai Nakamura, Oana Cociorva, Kazuhiro Yumoto, Anna Katrin Szardenings, John W. Kozarich, Bei Li, Marek Liyanage, Yasushi Kohno, Kyoko Okada, Kevin R. Shreder, Masahiro Nomura, Qiang Li, Arwin Aban
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
We previously disclosed tricylic, 6-carboxylic acid-bearing 4-quinolones as GSK-3β inhibitors. Herein we discuss the optimization of this series to yield a series of more potent 6-nitrile analogs with insignificant anti-microbial activity. Finally,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2d8edc0144cb84b1ce0ca668263e18
https://pubmed.ncbi.nlm.nih.gov/22202172
https://pubmed.ncbi.nlm.nih.gov/22202172
Publikováno v:
Organic Letters. 3:317-319
[figure: see text] Under the agency of N-bromosuccinimide, n-pentenyl glycosides, acetonitrile, and carboxylic acids participate in three-component-reactions that afford N-acylated glycosylamines. The procedure tolerate diverse donors, and C2-tetrach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a6c0d86924313d11b755d0b66b4c82
https://doi.org/10.1021/ol000265i
https://doi.org/10.1021/ol000265i