Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anna Katharina Ückert"'
Autor:
Katharina Ernst, Johannes Schmid, Matthias Beck, Marlen Hägele, Meike Hohwieler, Patricia Hauff, Anna Katharina Ückert, Anna Anastasia, Michael Fauler, Thomas Jank, Klaus Aktories, Michel R. Popoff, Cordelia Schiene-Fischer, Alexander Kleger, Martin Müller, Manfred Frick, Holger Barth
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Binary enterotoxins Clostridium (C.) botulinum C2 toxin, C. perfringens iota toxin and C. difficile toxin CDT are composed of a transport (B) and a separate non-linked enzyme (A) component. Their B-components mediate endocytic uptake into ma
Externí odkaz:
https://doaj.org/article/2307dc2fc83143dcbe2b740f45e9f84a
Autor:
Nadine Renner, Franziska Schöb, Regina Pape, Ilinca Suciu, Anna-Sophie Spreng, Anna-Katharina Ückert, Eike Cöllen, Federica Bovio, Bruno Chilian, Johannes Bauer, Stefan Röpcke, Jörg Bergemann, Marcel Leist, Stefan Schildknecht
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103165- (2024)
The activation of ferroptosis is being pursued in cancer research as a strategy to target apoptosis-resistant cells. By contrast, in various diseases that affect the cardiovascular system, kidneys, liver, and central and peripheral nervous systems, a
Externí odkaz:
https://doaj.org/article/f47909992c4d48088cd895285a0913c3
Autor:
Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Publikováno v:
Environment International, Vol 180, Iss , Pp 108229- (2023)
The causes of nigrostriatal cell death in idiopathic Parkinson’s disease are unknown, but exposure to toxic chemicals may play some role. We followed up here on suggestions that bacterial secondary metabolites might be selectively cytotoxic to dopa
Externí odkaz:
https://doaj.org/article/98f6e31215e34f1eb4609a9fec3612e4
Autor:
Ilinca Suciu, Johannes Delp, Simon Gutbier, Anna-Katharina Ückert, Anna-Sophie Spreng, Philipp Eberhard, Christiaan Karreman, Falk Schreiber, Katrin Madjar, Jörg Rahnenführer, Ivana Celardo, Ivano Amelio, Marcel Leist
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 164 (2023)
Proteasome inhibition is associated with parkinsonian pathology in vivo and degeneration of dopaminergic neurons in vitro. We explored here the metabolome (386 metabolites) and transcriptome (3257 transcripts) regulations of human LUHMES neurons, fol
Externí odkaz:
https://doaj.org/article/aba2f698f7c54e15a5b78be17f1451a9
Autor:
Mahshid Alimohammadi, Birthe Meyburg, Anna‐Katharina Ückert, Anna‐Katharina Holzer, Marcel Leist
This Project was performed to provide an in vitro Point of Departure (PoD) for an Adverse Outcome Pathway (AOP)-informed Integrated Approach to Testing and Assessment (IATA), concerning a potential risk of parkinsonian motor deficits after long-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130ad5daa221a17da87b41438ca9e1cf
Autor:
Liliana Capinha, Yaran Zhang, Anna-Katharina Holzer, Anna-Katharina Ückert, Melinda Zana, Giada Carta, Cormac Murphy, Jenna Baldovini, Zahra Mazidi, Johannes Grillari, Andras Dinnyes, Bob van de Water, Marcel Leist, Jan N. M. Commandeur, Paul Jennings
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 97(2), 523-545. Springer Verlag
Archives of Toxicology, 97, 523-545
Capinha, L, Zhang, Y, Holzer, A K, Ückert, A K, Zana, M, Carta, G, Murphy, C, Baldovini, J, Mazidi, Z, Grillari, J, Dinnyes, A, van de Water, B, Leist, M, Commandeur, J N M & Jennings, P 2023, ' Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models ', Archives of Toxicology, vol. 97, no. 2, pp. 523-545 . https://doi.org/10.1007/s00204-022-03436-6
Archives of Toxicology, 97(2), 523-545. Springer Verlag
Archives of Toxicology, 97, 523-545
Capinha, L, Zhang, Y, Holzer, A K, Ückert, A K, Zana, M, Carta, G, Murphy, C, Baldovini, J, Mazidi, Z, Grillari, J, Dinnyes, A, van de Water, B, Leist, M, Commandeur, J N M & Jennings, P 2023, ' Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models ', Archives of Toxicology, vol. 97, no. 2, pp. 523-545 . https://doi.org/10.1007/s00204-022-03436-6
Environmental or occupational exposure of humans to trichloroethylene (TCE) has been associated with different extrahepatic toxic effects, including nephrotoxicity and neurotoxicity. Bioactivation of TCE via the glutathione (GSH) conjugation pathway
Autor:
Michel R. Popoff, Holger Barth, Ann-Katrin Mittler, Marc Landenberger, Carsten Schwan, Carola Hoffmann-Richter, Stephan Fischer, Marlen Hägele, Roland Benz, Martin Müller, Panagiotis Papatheodorou, Klaus Aktories, Alexander Kleger, Ulrich Ziener, Anna-Katharina Ückert
Publikováno v:
The FASEB Journal. 34:6244-6261
The human pathogenic bacterium Clostridioides difficile produces two exotoxins TcdA and TcdB, which inactivate Rho GTPases thereby causing C. difficile-associated diseases (CDAD) including life-threatening pseudomembranous colitis. Hypervirulent stra
Autor:
Marcel Leist, Simon Gutbier, Joanna L. Elson, Liam Pearson, David Dickens, Véronique Hubscher-Bruder, David Tetard, Stefan Schildknecht, Sotiris Kyriakou, Frank W. Lewis, Jérémy Brandel, Sylvia Michel, Anna Katharina Ückert, Ilse S. Pienaar, Markus Brüll
Publikováno v:
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02826-y⟩
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02826-y⟩
While the etiology of non-familial Parkinson’s disease (PD) remains unclear, there is evidence that increased levels of tissue iron may be a contributing factor. Moreover, exposure to some environmental toxicants is considered an additional risk fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f77013f90544b89b21674f09ba07ba
https://hal.archives-ouvertes.fr/hal-02905604
https://hal.archives-ouvertes.fr/hal-02905604
Autor:
Markus Brüll, Timm Danker, Ilinca Suciu, Marcel Leist, Stefanie Klima, Clemens Möller, Jasmin Schaefer, Dominik Loser, Udo Kraushaar, Anna-Katharina Ückert
Publikováno v:
Archives of Toxicology
Prediction of drug toxicity on the human nervous system still relies mainly on animal experiments. Here, we developed an alternative system allowing assessment of complex signaling in both individual human neurons and on the network level. The LUHMES
Autor:
Michel R. Popoff, Anna Anastasia, Manfred Frick, Marlen Hägele, Martin Müller, Thomas Jank, Alexander Kleger, Klaus Aktories, Anna Katharina Ückert, Michael Fauler, Holger Barth, Patricia Hauff, Matthias H. Beck, Meike Hohwieler, Cordelia Schiene-Fischer, Katharina Ernst, Johannes A. Schmid
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.2724. ⟨10.1038/s41598-017-02882-y⟩
Scientific Reports, 2017, 7 (1), pp.2724. ⟨10.1038/s41598-017-02882-y⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.2724. ⟨10.1038/s41598-017-02882-y⟩
Scientific Reports, 2017, 7 (1), pp.2724. ⟨10.1038/s41598-017-02882-y⟩
Binary enterotoxins Clostridium (C.) botulinum C2 toxin, C. perfringens iota toxin and C. difficile toxin CDT are composed of a transport (B) and a separate non-linked enzyme (A) component. Their B-components mediate endocytic uptake into mammalian c