Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anna Karolina Blöchinger"'
Autor:
Perla Cota, Özüm Sehnaz Caliskan, Aimée Bastidas-Ponce, Changying Jing, Jessica Jaki, Lama Saber, Oliver Czarnecki, Damla Taskin, Anna Karolina Blöchinger, Thomas Kurth, Michael Sterr, Ingo Burtscher, Natalie Krahmer, Heiko Lickert, Mostafa Bakhti
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101853- (2024)
Objective: The consequences of mutations in genes associated with monogenic forms of diabetes on human pancreas development cannot be studied in a time-resolved fashion in vivo. More specifically, if recessive mutations in the insulin gene influence
Externí odkaz:
https://doaj.org/article/9e1e1763e24b47d79c646e24cd6e365f
Autor:
Johanna Siehler, Anna Karolina Blöchinger, Melis Akgün, Xianming Wang, Alireza Shahryari, Arie Geerlof, Heiko Lickert, Ingo Burtscher
Publikováno v:
Stem Cell Research, Vol 50, Iss , Pp 102126- (2021)
The peptide hormone insulin produced by pancreatic β-cells undergoes post-transcriptional processing before secretion. In particular, C-peptide is cleaved from pro-insulin to generate mature insulin. Here, we introduce a C-peptide-mCherry human iPSC
Externí odkaz:
https://doaj.org/article/d2add62c8bcb4c35b98b76baf568c85d
Autor:
Alireza Shahryari, Noel Moya, Johanna Siehler, Xianming Wang, Anna Karolina Blöchinger, Ingo Burtscher, Mostafa Bakhti, Seyed Javad Mowla, Heiko Lickert
Publikováno v:
Stem Cell Research, Vol 47, Iss , Pp 101927- (2020)
The INK4 locus is considered as a hot-spot region for the complex genetic disorders, including cancer, type 2 diabetes (T2D) and coronary artery disease (CAD). By CRISPR/Cas9 gene editing, we generated a human induced pluripotent stem cell (hiPSC) li
Externí odkaz:
https://doaj.org/article/1e94fa56a4784d65b5a290be112ce8d2
Autor:
Anna Karolina Blöchinger, Johanna Siehler, Katharina Wißmiller, Alireza Shahryari, Ingo Burtscher, Heiko Lickert
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Differentiating human induced pluripotent stem cells (hiPSCs) into insulin (INS)-producing β-like cells has potential for diabetes research and therapy. Here, we generated a heterozygous fluorescent hiPSC reporter, labeling INS-producing β-like cel
Externí odkaz:
https://doaj.org/article/b3f8a7273c8145ada236b664f5a550a3
Publikováno v:
Trends in Pharmacological Sciences. 41:384-386
In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32323a02a18725b7c71d046ccedeb99d
https://doi.org/10.1016/j.tips.2020.04.002
https://doi.org/10.1016/j.tips.2020.04.002
Autor:
Alireza Shahryari, Arie Geerlof, Heiko Lickert, Anna Karolina Blöchinger, Ingo Burtscher, Johanna Siehler, Melis Akgün, Xianming Wang
Publikováno v:
Stem Cell Res. 50:102126 (2021)
Stem Cell Research, Vol 50, Iss, Pp 102126-(2021)
Stem Cell Research, Vol 50, Iss, Pp 102126-(2021)
The peptide hormone insulin produced by pancreatic β-cells undergoes post-transcriptional processing before secretion. In particular, C-peptide is cleaved from pro-insulin to generate mature insulin. Here, we introduce a C-peptide-mCherry human iPSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3dbdc7a04ab691fa4de755476fbb99
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60892
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60892
Autor:
Noel Moya, Mostafa Bakhti, Alireza Shahryari, Seyed Javad Mowla, Johanna Siehler, Heiko Lickert, Ingo Burtscher, Xianming Wang, Anna Karolina Blöchinger
Publikováno v:
Stem Cell Res. 47:101927 (2020)
Stem Cell Research, Vol 47, Iss, Pp 101927-(2020)
Stem Cell Research, Vol 47, Iss, Pp 101927-(2020)
The INK4 locus is considered as a hot-spot region for the complex genetic disorders, including cancer, type 2 diabetes (T2D) and coronary artery disease (CAD). By CRISPR/Cas9 gene editing, we generated a human induced pluripotent stem cell (hiPSC) li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85882fdc415f1b8598fc7db8e0c5414
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59837
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59837
Autor:
Johanna Siehler, Katharina Wißmiller, Anna Karolina Blöchinger, Alireza Shahryari, Ingo Burtscher, Heiko Lickert
Publikováno v:
Stem Cell Res. 45:101797 (2020)
Stem Cell Research, Vol 45, Iss, Pp-(2020)
Stem Cell Research, Vol 45, Iss, Pp-(2020)
Differentiating human induced pluripotent stem cells (hiPSCs) into insulin (INS)-producing beta-like cells has potential for diabetes research and therapy. Here, we generated a heterozygous fluorescent hiPSC reporter, labeling INS-producing beta-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c840aaf5ea40ae792af6e7909712e8
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59004
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59004
Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual
Autor:
Anna Karolina Blöchinger, Thomas Meitinger, Julia Beckenbauer, Hans-Ulrich Häring, Heiko Lickert, Andrzej R. Malinowski, Xianming Wang, Johanna Siehler, Harald Staiger, Ingo Burtscher
Publikováno v:
Stem Cell Res. 39:101531 (2019)
Stem Cell Research, Vol 39, Iss, Pp-(2019)
Stem Cell Research, Vol 39, Iss, Pp-(2019)
Induced pluripotent stem cells (iPSCs) can be used to generate different somatic cell types in vitro, including insulin-producing pancreatic β-cells. Here, we have generated iPSCs from a healthy male individual using an episomal reprogramming method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4fd1a4b7c378313e5459261cb998f9
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56760
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56760
Publikováno v:
Nat. Rev. Drug Discov. 20, 920–940 (2021)
Nature Reviews Drug Discovery
Nature Reviews Drug Discovery
Diabetes mellitus is a metabolic disorder that affects more than 460 million people worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas type 2 diabetes (T2D) is caused by a hostile metabolic environment that lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14e6807a13e0593c43929158f80054a