Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

Autor: Tia DiTommaso, Lynelle K Jones, Denny L Cottle, WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P Sundberg, Jacqueline K White, Ian M Smyth

Publikováno v: PLoS Genetics, Vol 10, Iss 10, p e1004705 (2014)

The skin is a highly regenerative organ which plays critical roles in protecting the body and sensing its environment. Consequently, morbidity and mortality associated with skin defects represent a significant health issue. To identify genes importan

Externí odkaz: https://doaj.org/article/03c745db72054c98b2c15844f603b5cc

Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice.

Autor: Elisabeth Frank, Yizhen Wu, Naomi Piyaratna, William James Body, Peta Snikeris, Timothy South, Anna-Karin Gerdin, Mikael Bjursell, Mohammad Bohlooly-Y, Leonard Storlien, Xu-Feng Huang

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42395 (2012)

BACKGROUND: G-protein coupled receptors (GPR) bear the potential to serve as yet unidentified drug targets for psychiatric and metabolic disorders. GPR12 is of major interest given its putative role in metabolic function and its unique brain distribu

Externí odkaz: https://doaj.org/article/6ff18e654c5c46a180fb39f034eeb6a5

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Autor: Jacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C. Adams, David Tannahill, Darren W. Logan, Daniel G. MacArthur, Jonathan Flint, Vinit B. Mahajan, Stephen H. Tsang, Ian Smyth, Fiona M. Watt, William C. Skarnes, Gordon Dougan, David J. Adams, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel, Lauren Baker, Caroline Barnes, Ryan Beveridge, Emma Cambridge, Damian Carragher, Prabhjoat Chana, Kay Clarke, Yvette Hooks, Natalia Igosheva, Ozama Ismail, Hannah Jackson, Leanne Kane, Rosalind Lacey, David Tino Lafont, Mark Lucas, Simon Maguire, Katherine McGill, Rebecca E. McIntyre, Sophie Messager, Lynda Mottram, Lee Mulderrig, Selina Pearson, Hayley J. Protheroe, Laura-Anne Roberson, Grace Salsbury, Mark Sanderson, Daniel Sanger, Carl Shannon, Paul C. Thompson, Elizabeth Tuck, Valerie E. Vancollie, Lisa Brackenbury, Wendy Bushell, Ross Cook, Priya Dalvi, Diane Gleeson, Bishoy Habib, Matt Hardy, Kifayathullah Liakath-Ali, Evelina Miklejewska, Stacey Price, Debarati Sethi, Elizabeth Trenchard, Dominique von Schiller, Sapna Vyas, Anthony P. West, John Woodward, Elizabeth Wynn, Arthur Evans, David Gannon, Mark Griffiths, Simon Holroyd, Vivek Iyer, Christian Kipp, Morag Lewis, Wei Li, Darren Oakley, David Richardson, Damian Smedley, Chukwuma Agu, Jackie Bryant, Liz Delaney, Nadia I. Gueorguieva, Helen Tharagonnet, Anne J. Townsend, Daniel Biggs, Ellen Brown, Adam Collinson, Charles-Etienne Dumeau, Evelyn Grau, Sarah Harrison, James Harrison, Catherine E. Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, Tom Metcalf, Stuart Newman, Johanna Pass, Laila Pearson, Helen Reynolds, Caroline Sinclair, Hannah Wardle-Jones, Michael Woods, Liam Alexander, Terry Brown, Francesca Flack, Carole Frost, Nicola Griggs, Silvia Hrnciarova, Andrea Kirton, Jordan McDermott, Claire Rogerson, Gemma White, Pawel Zielezinski, Tia DiTommaso, Andrew Edwards, Emma Heath, Mary Ann Mahajan, Binnaz Yalcin

Publikováno v: Cell
Cell; Vol 154
Cell, 2013, 154, pp.452-464. ⟨10.1016/j.cell.2013.06.022⟩

Summary Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4537fde4bfb5a641d2d4531b15325c7
http://europepmc.org/articles/PMC3717207

Optimising experimental design for high-throughput phenotyping in mice: a case study

Autor: Natasha A. Karp, Ramiro Ramirez-Solis, Niels C. Adams, Lauren A. Baker, Anna-Karin Gerdin, Jacqueline K. White

Publikováno v: Mammalian Genome

To further the functional annotation of the mammalian genome, the Sanger Mouse Genetics Programme aims to generate and characterise knockout mice in a high-throughput manner. Annually, approximately 200 lines of knockout mice will be characterised us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4016f7da71601d9ff5368be5cd1ec5
http://europepmc.org/articles/PMC2974211

Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism

Autor: Jan Oscarsson, Karolina Ploj, Gunnel Arnerup, Mohammad Bohlooly-Y, Magdalena Rhedin, Anna-Karin Gerdin, Andrea Ahnmark, Lena William-Olsson, Daniel Lindén, Xiao-Rong Peng, Mikael Bjursell, Anna-Lena Berg, Anders Elmgren

Publikováno v: Diabetes. 56:583-593

The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and influences the risk for developing obesity, type 2 diabetes, and cardiovascular disease. Adiponectin binds to two different seven-transmembrane domain receptors term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d692a3230e92e6b549e67ce2d54bed
https://doi.org/10.2337/db06-1432