Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Anna K. Sundgren-Andersson"'
Publikováno v:
European Journal of Pain. 22:889-903
The transient receptor potential vanilloid receptor 1 (TRPV1) is a nonselective cation channel involved in the mediation of peripheral pain to the central nervous system. As such, the TRPV1 is an accessible molecular target that lends itself well to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4146b56eb43b1a6739c140f6ba92a2c
https://doi.org/10.1002/ejp.1175
https://doi.org/10.1002/ejp.1175
Autor:
Laurent Knerr, Udo Bauer, Shalini Andersson, Anna K. Sundgren-Andersson, Ulf Andersson, Ratan Bhat
Publikováno v:
Journal of Alzheimer's disease : JAD. 64(s1)
Spanning over three decades of extensive drug discovery research, the efforts to develop a potent and selective GSK3 inhibitor as a therapeutic for the treatment of type 2 diabetes, Alzheimer's disease (AD), bipolar disorders and cancer have been fut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f14d16c181074d07d226f26ae485c1
https://pubmed.ncbi.nlm.nih.gov/29758944
https://pubmed.ncbi.nlm.nih.gov/29758944
Autor:
T. Kullenberg, Anna K. Sundgren-Andersson, Märta Segerdahl, O. Stålberg, Magnus M. Halldin, B. Jonzon, Erik Sjögren
Publikováno v:
European journal of pain (London, England). 22(7)
Background The transient receptor potential cation channel subfamily V 1 (TRPV1) is involved in nociception and has thus been of interest for drug developers, as a target for novel analgesics. However, several oral TRPV1 antagonists have failed in de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd220fb3d7b7c118a5dfab9ddb767644
https://pubmed.ncbi.nlm.nih.gov/29504187
https://pubmed.ncbi.nlm.nih.gov/29504187
Autor:
Anna K. Sundgren-Andersson, Gregor Sisask, Richard Marsell, Sune Larsson, Kenneth B. Jonsson, Östen Ljunggren, Olle Nilsson
Publikováno v:
Bone. 54:126-132
Fracture healing is a complex interplay between endochondral and intramembranous bone formation processes. The canonical Wnt/β-catenin pathway enhances new bone formation and may play a role in fracture healing. Glycogen synthase kinase 3β (GSK3β)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f45fd1f88f346012e6251a67f68a110
https://doi.org/10.1016/j.bone.2013.01.019
https://doi.org/10.1016/j.bone.2013.01.019
Autor:
Erik Sjögren, Magnus M. Halldin, Anna K. Sundgren-Andersson, Sara B. E. Andersson, Olle Stålberg
Publikováno v:
Journal of pharmaceutical sciences. 105(9)
Cyclodextrins (CD) have the ability to form inclusion complexes with drugs and can be used as excipients to enhance solubility of poorly soluble drugs. To make accurate estimations of the potency of the drug, knowledge of the free drug concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54796efc99bececf062eca88ca559e11
https://pubmed.ncbi.nlm.nih.gov/27431012
https://pubmed.ncbi.nlm.nih.gov/27431012
Autor:
Mickaël Maudet, Jennifer M. A. Laird, Ronald Zemribo, Paul Jones, Michael Dabrowski, Andis Slaitas, Yevgeni Besidski, Gitte Terp, Karin Kolmodin, Andrea Penwell, Andrew Griffin, Didier Rotticci, Anna K. Sundgren-Andersson, Christopher Walpole, Dean Johnson, Alexander Munro, Yin Hu, Therese Lundström, Maryse Labarre, Inger Kers, Huascar Villanueva, Johan Bylund, Martin Nylöf, Mats Svensson, Denis Labrecque, Magali Harter, Sandrine Leclerc, William Brown, Sophie Dautrey, Shawn Johnstone, John Martino, Lucy Horoszok
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6205-6211
Benzothiazole amides were identified as TRPV1 antagonists from high throughput screening using recombinant human TRPV1 receptor and structure-activity relationships were explored to pinpoint key pharmacophore interactions. By increasing aqueous solub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5999ae8c775dbcf4f87b0f920411e95
https://doi.org/10.1016/j.bmcl.2012.08.018
https://doi.org/10.1016/j.bmcl.2012.08.018
Autor:
Sune Larsson, Ulf Andersson, Kenneth B. Jonsson, Östen Ljunggren, Anna K. Sundgren-Andersson, Olle Nilsson, Richard Marsell, Gregor Sisask, Yvonne Nilsson
Publikováno v:
Bone. 50:619-627
Glycogen synthase kinase 3β (GSK-3β) actions are central in the canonical Wnt pathway, important in many biological processes and a potential drug target for treating several diseases. It is appreciated that a balanced Wnt canonical signaling is cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e2cab3de3b6c50fd8e7d2a8d98faca
https://doi.org/10.1016/j.bone.2011.11.007
https://doi.org/10.1016/j.bone.2011.11.007
Publikováno v:
Brain Research. 1043:1-11
The medial preoptic nucleus (MPN) is the major nucleus of the preoptic area (POA), a hypothalamic area involved in the regulation of body-temperature. Injection of capsaicin into this area causes hypothermia in vivo. Capsaicin also causes glutamate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112a16cbd2fbf3d9e0b16dac341966f8
https://doi.org/10.1016/j.brainres.2004.10.064
https://doi.org/10.1016/j.brainres.2004.10.064
Autor:
D. James Surmeier, Heidi E. Hamm, Theresa M. Cabrera-Vera, Anna K. Sundgren-Andersson, Laurie R. Earls, Martina Medkova, Salvador Hernandez
Publikováno v:
Proceedings of the National Academy of Sciences. 101:16339-16344
Regulator of G protein signaling (RGS) proteins negatively regulate receptor-mediated second messenger responses by enhancing the GTPase activity of Gα subunits. We describe a receptor-specific role for an RGS protein at the level of an individual b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df04f39daa7cdfcbb50c3a777f5b25ef
https://doi.org/10.1073/pnas.0407416101
https://doi.org/10.1073/pnas.0407416101
Publikováno v:
Annals of the New York Academy of Sciences. 856:48-52
Bacterial lipopolypolysaccharide (LPS)-induced fever involves induction of the proinflammatory cytokines interleukin (IL)-1 alpha, IL-1 beta, tumor necrosis factor-alpha (TNF-alpha), and IL-6, both in the periphery and in the brain. These molecules c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb0438a1c61f86b2409c71ce9feaa36
https://doi.org/10.1111/j.1749-6632.1998.tb08311.x
https://doi.org/10.1111/j.1749-6632.1998.tb08311.x