Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Anna K. Kopec"'
Autor:
Melissa A. Bates, Peyman Akbari, Kristen N. Gilley, James G. Wagner, Ning Li, Anna K. Kopec, Kathryn A. Wierenga, Daven Jackson-Humbles, Christina Brandenberger, Andrij Holian, Abby D. Benninghoff, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Ectopic lymphoid structures (ELS) consist of B-cell and T-cell aggregates that are initiated de novo in inflamed tissues outside of secondary lymphoid organs. When organized within follicular dendritic cell (FDC) networks, ELS contain functional germ
Externí odkaz:
https://doaj.org/article/b4642ab0353c4492b537d870d8e55c4f
Autor:
Lauren G. Poole, Matthew J. Flick, Dafna J. Groeneveld, Anna K. Kopec, Kevin S. Baker, Asmita Pant, Holly Cline-Fedewa, James P. Luyendyk
Publikováno v:
Blood
Intravascular fibrin clot formation follows a well-ordered series of reactions catalyzed by thrombin cleavage of fibrinogen leading to fibrin polymerization and cross-linking by factor XIIIa (FXIIIa). Extravascular fibrin(ogen) deposits are observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27033e09a9298c84972b4b355e78754a
https://doi.org/10.1182/blood.2020007415
https://doi.org/10.1182/blood.2020007415
Autor:
Brett D. Hollingshead, Anna K. Kopec, Yutian Zhan, Timothy P. LaBranche, John W. Davis, Kyle Hayes, Srinivasa R. Mantena, Andrew W. Harrington, Laurence O. Whiteley, Zachary S. Stewart, Andrew D. Burdick
Publikováno v:
Toxicologic Pathology. 48:994-1007
Fatty liver disease is a potential risk factor for drug-induced liver injury (DILI). Despite advances in nonclinical in vitro and in vivo models to assess liver injury during drug development, the pharmaceutical industry is still plagued by idiosyncr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345317f50829520d91ae5176802b72bd
https://doi.org/10.1177/0192623320968716
https://doi.org/10.1177/0192623320968716
Autor:
Lori A. Holle, Adam Miszta, Asmita Pant, Kirk C. Hansen, Daniel A. Lawrence, Anna K. Kopec, Alisa S. Wolberg, James R. Byrnes, Bas de Laat, James P. Luyendyk, Matthew J. Flick
Publikováno v:
Blood, 135(19), 1704-1717. The American Society of Hematology
Blood
Blood
Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and drives obesity pathophysiology, but a lack of essential analytical tools has left fibrinolyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc41635d6f47ad0b66efa99621ba534
https://doi.org/10.1182/blood.2019004267
https://doi.org/10.1182/blood.2019004267
Publikováno v:
J Thromb Haemost
BACKGROUND: The blood coagulation factor fibrin(ogen) can modulate inflammation by altering leukocyte activity. Analyses of fibrin(ogen)-mediated proinflammatory activity have largely focused on leukocyte integrin binding activity revealed by convers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641f9fd39a9cfa870b5761af90e8636d
https://pubmed.ncbi.nlm.nih.gov/35158413
https://pubmed.ncbi.nlm.nih.gov/35158413
Autor:
Xiaoting, Wang, Anna K, Kopec, Mark, Collinge, Rhiannon, David, Christian, Grant, Rhiannon N, Hardwick, Aaron, Navratil, Nirav, Patel, Wendy, Rowan, Nikki, Marshall
Publikováno v:
ALTEX.
Immune responses are heavily involved in the regulation and pathogenesis of human diseases, including infectious diseases, inflammatory and autoimmune conditions, cancer, neurological disorders and cardiometabolic syndromes. The immune system has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f5111251a971a4344f5cc1a52980a2
https://doi.org/10.14573/altex.2205311
https://doi.org/10.14573/altex.2205311
Autor:
Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert
Publikováno v:
ALTEX.
Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/ or efficacy concerns. For this technology to have an impact, the establishment of robust characterization and qualification plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991b82190055f9a932fb29fb1692bafd
https://doi.org/10.14573/altex.2112203
https://doi.org/10.14573/altex.2112203
Autor:
Holly Cline-Fedewa, James P. Luyendyk, Dafna J. Groeneveld, Anna K. Kopec, Lauren G. Poole, Anna-Katherine Fournier
Publikováno v:
Toxicology
Acute and chronic liver disease are associated with substantial alterations in the hemostatic system, including elevated levels of the platelet-adhesive protein von Willebrand factor (VWF). Carbon tetrachloride-induced liver fibrosis is reduced in VW
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24de19dbac66d402f4c3dbd517eae69f
https://europepmc.org/articles/PMC8585719/
https://europepmc.org/articles/PMC8585719/
Autor:
Yogesh Saini, Steven P Proper, Peter Dornbos, Krista K Greenwood, Anna K Kopec, Scott G Lynn, Elizabeth Grier, Lyle D Burgoon, Timothy R Zacharewski, Russell S Thomas, Jack R Harkema, John J LaPres
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139270 (2015)
Hypoxia is a state of decreased oxygen reaching the tissues of the body. During prenatal development, the fetus experiences localized occurrences of hypoxia that are essential for proper organogenesis and survival. The response to decreased oxygen av
Externí odkaz:
https://doaj.org/article/c0498e3a87474fb8b32ee6bc4158ab1d
Autor:
Christine P. Bono, Mazin Derzi, Lindsay Tomlinson, Bart Jessen, Anna K. Kopec, James E. Finley, Ikuo Horii, John E. Burkhardt, Shuyan Lu, Carol B. Donovan, Julie Harney, Mark Collinge, Andrew D. Burdick, Ryuji Yokokawa, Ramin Banan Sadeghian, Nasir K. Khan, Jessica Roy
Publikováno v:
The Journal of toxicological sciences. 46(3)
Microphysiological systems (MPS) are making advances to provide more standardized and predictive physiologically relevant responses to test articles in living tissues and organ systems. The excitement surrounding the potential of MPS to better predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9e5347e752a79f1985fa87509e7116
https://pubmed.ncbi.nlm.nih.gov/33642521
https://pubmed.ncbi.nlm.nih.gov/33642521