Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anna K Kania"'
Autor:
Zhihong Zuo, Anna K. Kania, Dillon G. Patterson, Sakeenah L. Hicks, Jeffrey Maurer, Mansi Gupta, Jeremy M. Boss, Christopher D. Scharer
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17527- (2023)
The transcription factor Interferon regulatory factor 8 (IRF8) is involved in maintaining B cell identity. However, how IRF8 regulates T cell independent B cell responses are not fully characterized. Here, an in vivo CRISPR/Cas9 system was optimized
Externí odkaz:
https://doaj.org/article/e2d535e0932a4c759017e58be7c52fae
Autor:
Michael D. Powell, Peiyuan Lu, Dennis K. Neeld, Anna K. Kania, Lou-Ella M. M. George-Alexander, Alexander P. R. Bally, Christopher D. Scharer, Jeremy M. Boss
Publikováno v:
ImmunoHorizons. 6:872-882
CD8 cytotoxic T cells are a potent line of defense against invading pathogens. To aid in curtailing aberrant immune responses, the activation status of CD8 T cells is highly regulated. One mechanism in which CD8 T cell responses are dampened is via s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33cf5c8172df583c388c40cdfeda14a
https://doi.org/10.4049/immunohorizons.2100112
https://doi.org/10.4049/immunohorizons.2100112
Autor:
Christopher D. Scharer, James R. Rose, Madeline J. Price, Anna K. Kania, Jeremy M. Boss, Dillon G. Patterson
Publikováno v:
J Immunol
Cell division is an essential component of B cell differentiation to Ab-secreting plasma cells, with critical reprogramming occurring during the initial stages of B cell activation. However, a complete understanding of the factors that coordinate ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295cc11b9b7abbe93a826fea021a83ea
https://doi.org/10.4049/jimmunol.2100440
https://doi.org/10.4049/jimmunol.2100440
Publikováno v:
Immunol Rev
Humoral immunity provides protection from pathogenic infection and is mediated by antibodies following the differentiation of naive B cells (nBs) to antibody-secreting cells (ASCs). This process requires substantial epigenetic and transcriptional rew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a299144ac293529bfc284641d143a15
https://doi.org/10.1111/imr.12975
https://doi.org/10.1111/imr.12975
Autor:
Anna K. Kania, Madeline J. Price, Lou-Ella George-Alexander, Dillon G. Patterson, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Publikováno v:
J Immunol
B cell differentiation is associated with substantial transcriptional, metabolic, and epigenetic remodeling, including redistribution of histone 3 lysine 27 trimethylation (H3K27me3), which is associated with a repressive chromatin state and gene sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31bf75340854ccc07015a3a9e912776
https://pubmed.ncbi.nlm.nih.gov/35346967
https://pubmed.ncbi.nlm.nih.gov/35346967
Autor:
Jeremy M. Boss, Anna K. Kania, Madeline J. Price, Christopher D. Scharer, James R. Rose, Dillon G. Patterson
Cell division is an essential component of B cell differentiation to antibody-secreting plasma cells, with critical reprogramming occurring during the initial stages of B cell activation. However, a complete understanding of the factors that coordina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547e49cfcee74ed51e680df386da520a
https://doi.org/10.1101/2021.06.20.449155
https://doi.org/10.1101/2021.06.20.449155
Memory B cells (MBCs) have enhanced capabilities to differentiate to plasma cells and generate a rapid burst of antibodies upon secondary stimulation. To determine if MBCs harbor an epigenetic landscape that contributes to increased differentiation p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ffdcbe4728f32442c5abee4a2d5709
https://doi.org/10.1101/2021.01.20.427446
https://doi.org/10.1101/2021.01.20.427446
Publikováno v:
The Journal of Immunology. 206:98.35-98.35
The differentiation of naïve B cells to antibody secreting plasma cells plays a crucial role in humoral immunity. This process is regulated by multiple factors including, transcription factors and epigenetic modifiers. Type II, clustered, regularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::427ee5c74dbd00213f1ce48887fe39c0
https://doi.org/10.4049/jimmunol.206.supp.98.35
https://doi.org/10.4049/jimmunol.206.supp.98.35
Autor:
Anna K. Kania, Dillon G. Patterson, Madeline J. Price, Troy D. Randall, Robert R. Haines, Muyao Guo, Jeremy M. Boss, Benjamin G. Barwick, John E. Bradley, Christopher D. Scharer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(3)
Epigenetic remodeling is required during B cell differentiation. However, little is known about the direct functions of epigenetic enzymes in Ab-secreting cells (ASC) in vivo. In this study, we examined ASC differentiation independent of T cell help
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c42a2cd821d51a67cd0c47e854fa8fc
https://pubmed.ncbi.nlm.nih.gov/29288200
https://pubmed.ncbi.nlm.nih.gov/29288200
Autor:
Madeline J Price, Christopher D. Scharer, Anna K Kania, Tian Mi, Sakeenah L Hicks, Troy D Randall, Jeremy Boss
Publikováno v:
The Journal of Immunology. 202:123.8-123.8
Immunological memory is a hallmark of the adaptive immune response. Memory B cells (MBC) have increased affinity, expression of costimulatory molecules, and capacity to proliferate and differentiate than their naïve counterparts; however, the epigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cfe19b41f511a647ca2f614b09d07be
https://doi.org/10.4049/jimmunol.202.supp.123.8
https://doi.org/10.4049/jimmunol.202.supp.123.8