Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Anna Köferle"'
Autor:
Thomas Hoffmann, Alexandra Hörmann, Maja Corcokovic, Jakub Zmajkovic, Matthias Hinterndorfer, Jasko Salkanovic, Fiona Spreitzer, Anna Köferle, Katrin Gitschtaler, Alexandra Popa, Sarah Oberndorfer, Florian Andersch, Markus Schaefer, Michaela Fellner, Nicole Budano, Jan G Ruppert, Paolo Chetta, Melanie Wurm, Johannes Zuber, Ralph A Neumüller
Publikováno v:
eLife, Vol 12 (2023)
Loss-of-function genetic tools are widely applied for validating therapeutic targets, but their utility remains limited by incomplete on- and uncontrolled off-target effects. We describe artificial RNA interference (ARTi) based on synthetic, ultra-po
Externí odkaz:
https://doaj.org/article/5be3978b927a49d695b800fdcd6cb2bb
Autor:
Valentin Baumann, Maximilian Wiesbeck, Christopher T. Breunig, Julia M. Braun, Anna Köferle, Jovica Ninkovic, Magdalena Götz, Stefan H. Stricker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Master transcription factors dominantly direct cell fate and barriers ensuring their tissue specific silencing are not clearly defined. Here, the authors demonstrate that inefficient targeted transactivation of Sox1 in neural progenitor cells is surm
Externí odkaz:
https://doaj.org/article/c84676bceefe4d2ea9650ddd58251fa5
Autor:
Christopher T Breunig, Tamara Durovic, Andrea M Neuner, Valentin Baumann, Maximilian F Wiesbeck, Anna Köferle, Magdalena Götz, Jovica Ninkovic, Stefan H Stricker
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196015 (2018)
Novel applications based on the bacterial CRISPR system make genetic, genomic, transcriptional and epigenomic engineering widely accessible for the first time. A significant advantage of CRISPR over previous methods is its tremendous adaptability due
Externí odkaz:
https://doaj.org/article/34f90e512d3b44eca2bdc200b388fb37
Autor:
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Fiona Spreitzer, Alexandra Popa, Venu Thatikonda, Teresa Puchner, Verena Supper, Madhwesh C. Ravichandran, Sarah Oberndorfer, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Barbara Mair, Ralph A. Neumüller
Publikováno v:
Cancer Research. 82:4004-4004
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef1d7607419cdd22e074905dbf74f20
https://doi.org/10.1158/1538-7445.am2022-4004
https://doi.org/10.1158/1538-7445.am2022-4004
Autor:
Birgit Wilding, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro, Paolo Chetta, Renate Schnitzer, Dana A. Botesteanu, Christoph Reiser, Stefan Kornigg, Petr Knesl, Alexandra Hörmann, Anna Köferle, Maja Corcokovic, Simone Lieb, Guido Scholz, Jens Bruchhaus, Markus Spina, Josef Balla, Biljana Peric-Simov, Jasmin Zimmer, Sophie Mitzner, Thomas N. Fett, Alexandra Beran, Lyne Lamarre, Thomas Gerstberger, Daniel Gerlach, Markus Bauer, Andreas Bergner, Andreas Schlattl, Gerd Bader, Matthias Treu, Harald Engelhardt, Stephan Zahn, Julian E. Fuchs, Johannes Zuber, Peter Ettmayer, Mark Pearson, Mark Petronczki, Norbert Kraut, Darryl B. McConnell, Flavio Solca, Ralph A. Neumüller
Publikováno v:
Nature cancer. 3(7)
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine kinase domain and cluster in exon 20 of the ERBB2 gene. Most clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57bd9ab03550201530aeff623cc359c
https://pubmed.ncbi.nlm.nih.gov/35883002
https://pubmed.ncbi.nlm.nih.gov/35883002
Autor:
Fiona Spreitzer, Corinna Wieshofer, Barbara Mair, Alexandra Popa, Christoph Reiser, Alexandra Hörmann, Andreas Schlattl, Sarah Oberndorfer, Venu Thatikonda, Anna Köferle, Ralph A. Neumüller, Teresa Puchner, Mark Pearson, Simon Wöhrle, Maja Corcokovic, Johannes Popow
Genetic networks are characterized by extensive buffering. During tumour evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1227f1a8fc42b44d97b2ca782bbe5f05
https://doi.org/10.1101/2021.05.21.445116
https://doi.org/10.1101/2021.05.21.445116
Autor:
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Venu Thatikonda, Alexandra Popa, Fiona Spreitzer, Madhwesh C. Ravichandran, Verena Supper, Sarah Oberndorfer, Teresa Puchner, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Javier Martinez, Stefan Weitzer, Barbara Mair, Ralph A. Neumüller
Publikováno v:
Cell Reports. 39:110636
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of functional redundancies can create de novo vulnerabilities that are specific to cancer cells. Here, we systematically search for cancer-relevant paralog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2bb486e7a7e4103639150fed5c4db8
https://doi.org/10.1016/j.celrep.2022.110636
https://doi.org/10.1016/j.celrep.2022.110636
Autor:
Valentin Baumann, Andrea M. Neuner, Christopher T. Breunig, Anna Köferle, Maximilian F. Wiesbeck, Stefan H. Stricker
Publikováno v:
Physiol. Rev. 101, 177-211 (2021)
Given the large amount of genome-wide data that have been collected during the last decades, a good understanding of how and why cells change during development, homeostasis, and disease might be expected. Unfortunately, the opposite is true; trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e9641f80e9e6a519c6804c78dec8be
https://pubmed.ncbi.nlm.nih.gov/32525760
https://pubmed.ncbi.nlm.nih.gov/32525760
Autor:
Christopher T. Breunig, Julia M. Braun, Anna Köferle, Valentin Baumann, Magdalena Götz, Jovica Ninkovic, Stefan H. Stricker, Maximilian F. Wiesbeck
Publikováno v:
Nat. Commun. 10:2119 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Master transcription factors have the ability to direct and reverse cellular identities, and consequently their genes must be subject to particular transcriptional control. However, it is unclear which molecular processes are responsible for impeding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6dbd849aa26c228a9561d627f9c5181
https://doi.org/10.1038/s41467-019-10146-8
https://doi.org/10.1038/s41467-019-10146-8
Autor:
Xi-Ming Sun, Anna Köferle, Wenhao Tang, Jürg Bähler, Malika Saint, Laurence Game, François Bertaux, Samuel Marguerat, Vahid Shahrezaei
Phenotypic cell-to-cell variability is a fundamental determinant of microbial fitness that contributes to stress adaptation and drug resistance. Gene expression heterogeneity underpins this variability but is challenging to study genome-wide. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4608ec186d9c667f60e91b60d6c8ff
http://hdl.handle.net/10044/1/66903
http://hdl.handle.net/10044/1/66903