Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anna K, Tickler"'
Autor:
Anna K Tickler, Sally L. Gras, Glyn L. Devlin, Michael A. Horton, Cait E. MacPhee, Christopher M. Dobson, Adam M. Squires
Publikováno v:
Biomaterials. 29:1553-1562
We describe experiments designed to explore the possibility of using amyloid fibrils as new nanoscale biomaterials for promoting and exploiting cell adhesion, migration and differentiation in vitro. We created peptides that add the biological cell ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defc04fce675df0c987d83eff2235c1d
https://doi.org/10.1016/j.biomaterials.2007.11.028
https://doi.org/10.1016/j.biomaterials.2007.11.028
Publikováno v:
Protein & Peptide Letters. 12:513-519
The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a7e49fb4e47d05a9e4ecdff8247abf
https://doi.org/10.2174/0929866054395905
https://doi.org/10.2174/0929866054395905
Publikováno v:
Protein & Peptide Letters. 11:377-384
The phenomenon of "difficult sequence" has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures are available to minimize or even abolish the negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60b9a0acffbac6ea9943151d18ccd1ab
https://doi.org/10.2174/0929866043406986
https://doi.org/10.2174/0929866043406986
Publikováno v:
Journal of Peptide Science. 7:488-494
Previous studies have shown the amyloid peptides, Abeta 1-40/42, to be exceptionally difficult to assemble by Fmoc-solid phase peptide synthesis due to the high hydrophobicity of the C-terminal segment and resulting on-resin aggregation. We found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad007a3550e020eebad150001a5418e
https://doi.org/10.1002/psc.342
https://doi.org/10.1002/psc.342
Autor:
Steven W. Magennis, Carlos Silva, Cait E. MacPhee, Glyn L. Devlin, Kevin Channon, Anna K Tickler, Chris E. Finlayson
Publikováno v:
Journal of the American Chemical Society. 130(16)
We describe the formation of self-assembling nanoscale fibrillar aggregates from a hybrid system comprising a short polypeptide conjugated to the fluorophore fluorene. The fibrils are typically unbranched, approximately 7 nm in diameter, and many mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1157a3f9a64cbd38159e1b624ad6700
https://pubmed.ncbi.nlm.nih.gov/18376824
https://pubmed.ncbi.nlm.nih.gov/18376824
Autor:
Christopher M. Dobson, Sally L. Gras, Glyn L. Devlin, Anna K Tickler, Cait E. MacPhee, Adam M. Squires
Publikováno v:
Journal of the American Chemical Society. 128(36)
We have investigated the effect of sample hydration on the wide-angle X-ray scattering patterns of amyloid fibrils from two different sources, hen egg white lysozyme (HEWL) and an 11-residue peptide taken from the sequence of transthyretin (TTR105-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a80127b9987139dba3146396bc3e128
https://pubmed.ncbi.nlm.nih.gov/16953596
https://pubmed.ncbi.nlm.nih.gov/16953596
Publikováno v:
Journal of Neuroinflammation, Vol 3, Iss 1, p 24 (2006)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundAlzheimer's disease is characterized by the accumulation of neuritic plaques, containing activated microglia and β-amyloid peptides (Aβ). Fibrillar Aβ can activate microglia, resulting in production of toxic and inflammatory mediators li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183b26ae06fd8973b6c1a74c20fbaa26
http://www.jneuroinflammation.com/content/3/1/24
http://www.jneuroinflammation.com/content/3/1/24
Publikováno v:
Protein and peptide letters. 12(6)
The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db912d42e390678f154c7b1d697d5a75
https://pubmed.ncbi.nlm.nih.gov/16101387
https://pubmed.ncbi.nlm.nih.gov/16101387
Publikováno v:
ChemInform. 36
The phenomenon of "difficult sequence" has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures are available to minimize or even abolish the negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb706984dad5fb9f6fecc52e286f288
https://doi.org/10.1002/chin.200523256
https://doi.org/10.1002/chin.200523256
Autor:
Cyril C. Curtain, Robert A. Cherny, Roberto Cappai, Anna K. Tickler, Ashley I. Bush, Giuseppe D. Ciccotosto, John D. Wade, Deborah J. Tew, Colin L. Masters, Danielle G. Smith, Darryl Carrington, Kevin J. Barnham
Publikováno v:
The Journal of biological chemistry. 280(14)
The toxicity of the amyloid-beta peptide (Abeta) is thought to be responsible for the neurodegeneration associated with Alzheimer disease. Generation of hydrogen peroxide has been implicated as a key step in the toxic pathway. Abeta coordinates the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac3f6ae25a2475ed7f308392fbedddb
https://pubmed.ncbi.nlm.nih.gov/15668252
https://pubmed.ncbi.nlm.nih.gov/15668252