Hyperoxia and Antioxidants for Myocardial Injury in Noncardiac Surgery:A 2 × 2 Factorial, Blinded, Randomized Clinical Trial

Autor: Cecilie, Holse, Eske K, Aasvang, Morten, Vester-Andersen, Lars S, Rasmussen, Jørn, Wetterslev, Robin, Christensen, Lars N, Jorgensen, Sofie S, Pedersen, Frederik C, Loft, Hannibal, Troensegaard, Marie-Louise, Mørkenborg, Zara R, Stisen, Kim, Rünitz, Jonas P, Eiberg, Anna K, Hansted, Christian S, Meyhoff, Cecilie M B, Jensen

Publikováno v: Holse, C, Aasvang, E K, Vester-Andersen, M, Rasmussen, L S, Wetterslev, J, Christensen, R, Jorgensen, L N, Pedersen, S S, Loft, F C, Troensegaard, H, Mørkenborg, M L, Stisen, Z R, Rünitz, K, Eiberg, J P, Hansted, A K, Meyhoff, C S & VIXIE Trial Group 2022, ' Hyperoxia and Antioxidants for Myocardial Injury in Noncardiac Surgery : A 2 × 2 Factorial, Blinded, Randomized Clinical Trial ', Anesthesiology, vol. 136, no. 3, pp. 408-419 . https://doi.org/10.1097/ALN.0000000000004117

Background Hyperoxia and oxidative stress may be associated with increased risk of myocardial injury. The authors hypothesized that a perioperative inspiratory oxygen fraction of 0.80 versus 0.30 would increase the degree of myocardial injury within

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