Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Anna Jeffery-Smith"'
Autor:
Saher Choudhry, Thomas A. J. Rowland, Kamil McClelland, Erik Renz, Nalini Iyanger, J Yimmy Chow, Felicity Aiano, Shamez N. Ladhani, Anna Jeffery-Smith, Nick J. Andrews, Maria Zambon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionFollowing the emergence of SARS-CoV-2 in 2020, care homes were disproportionately impacted by high mortality and morbidity of vulnerable elderly residents. Non-pharmaceutical interventions (NPIs) and improved infection control measures to
Externí odkaz:
https://doaj.org/article/836e1f9ccc354c0db91a95471e530ab1
Autor:
Emma Touizer, Aljawharah Alrubayyi, Rosemarie Ford, Noshin Hussain, Pehuén Pereyra Gerber, Hiu-Long Shum, Chloe Rees-Spear, Luke Muir, Ester Gea-Mallorquí, Jakub Kopycinski, Dylan Jankovic, Anna Jeffery-Smith, Christopher L. Pinder, Thomas A. Fox, Ian Williams, Claire Mullender, Irfaan Maan, Laura Waters, Margaret Johnson, Sara Madge, Michael Youle, Tristan J. Barber, Fiona Burns, Sabine Kinloch, Sarah Rowland-Jones, Richard Gilson, Nicholas J. Matheson, Emma Morris, Dimitra Peppa, Laura E. McCoy
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105862- (2023)
Summary: We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb)
Externí odkaz:
https://doaj.org/article/95e40d2350b047459324835a55cd7d61
Autor:
Stephanie Kucykowicz, Oliver E. Amin, Alice R. Burton, Leo Swadling, Nathalie M. Schmidt, Nekisa Zakeri, Jessica Davies, Gloryanne Aidoo-Micah, Kerstin A. Stegmann, Nicholas J. Easom, Anna Jeffery-Smith, Mala K. Maini, Laura J. Pallett
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101356- (2022)
Summary: With the growing appreciation of tissue-resident immunity, studying tissue-specific immune cells contributing to both homeostasis and disease is imperative. Here, we provide a protocol for the isolation of human intrahepatic leukocytes (IHL)
Externí odkaz:
https://doaj.org/article/45abae595f3b493592066ff2dfbe21a4
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Autor:
Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating, Mala K. Maini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses
Externí odkaz:
https://doaj.org/article/80c091a62a0e452aadda8e67b452162c
Autor:
Anna Jeffery-Smith, Alice R. Burton, Sabela Lens, Chloe Rees-Spear, Jessica Davies, Monika Patel, Robin Gopal, Luke Muir, Felicity Aiano, Katie J. Doores, J. Yimmy Chow, Shamez N. Ladhani, Maria Zambon, Laura E. McCoy, Mala K. Maini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median a
Externí odkaz:
https://doaj.org/article/4e603982f9904faf8768698a2faaf045
Autor:
Georgina Ireland, Anna Jeffery-Smith, Maria Zambon, Katja Hoschler, Ross Harris, John Poh, Frances Baawuah, Joanne Beckmann, Ifeanyichukwu O Okike, Shazaad Ahmad, Joanna Garstang, Andrew J Brent, Bernadette Brent, Felicity Aiano, Zahin Amin-Chowdhury, Louise Letley, Samuel E I Jones, Meaghan Kall, Monika Patel, Robin Gopal, Ray Borrow, Ezra Linley, Gayatri Amirthalingam, Kevin E Brown, Mary E Ramsay, Shamez N Ladhani
Publikováno v:
EClinicalMedicine, Vol 41, Iss , Pp 101150- (2021)
Background: Prospective, longitudinal SARS-CoV-2 sero-surveillance in schools across England was initiated after the first national lockdown, allowing comparison of child and adult antibody responses over time. Methods: Prospective active serological
Externí odkaz:
https://doaj.org/article/f4994eed9bfc4b9b971a26b164194940
Autor:
Anna Jeffery-Smith, Kate Dun-Campbell, Roshni Janarthanan, Jonathan Fok, Emma Crawley-Boevey, Amoolya Vusirikala, Elena Fernandez Ruiz De Olano, Marina Sanchez Perez, Suzanne Tang, Thomas AJ Rowland, Edward Wynne-Evans, Anita Bell, Bharat Patel, Zahin Amin-Chowdhury, Felicity Aiano, Karthik Paranthaman, Thomas Ma, Maria Saavedra-Campos, Joanna Ellis, Angie Lackenby, Heather Whitaker, Richard Myers, Katja Höschler, Kevin Brown, Mary E Ramsay, Nandini Shetty, J. Yimmy Chow, Shamez Ladhani, Maria Zambon
Publikováno v:
The Lancet Regional Health. Europe, Vol 3, Iss , Pp 100038- (2021)
Background: Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave
Externí odkaz:
https://doaj.org/article/aa4de7ede6af49149aee132f707d3366
Autor:
Shamez N Ladhani, Anna Jeffery-Smith, Monika Patel, Roshni Janarthanan, Jonathan Fok, Emma Crawley-Boevey, Amoolya Vusirikala, Elena Fernandez Ruiz De Olano, Marina Sanchez Perez, Suzanne Tang, Kate Dun-Campbell, Edward Wynne- Evans, Anita Bell, Bharat Patel, Zahin Amin-Chowdhury, Felicity Aiano, Karthik Paranthaman, Thomas Ma, Maria Saavedra-Campos, Joanna Ellis, Meera Chand, Kevin Brown, Mary E. Ramsay, Susan Hopkins, Nandini Shetty, J. Yimmy Chow, Robin Gopal, Maria Zambon
Publikováno v:
EClinicalMedicine, Vol 28, Iss , Pp 100597- (2020)
Background: We investigated six London care homes experiencing a COVID-19 outbreak and found high rates of SARS-CoV-2 infection among residents and staff. Here we report follow-up investigations including antibody testing in the same care homes five
Externí odkaz:
https://doaj.org/article/8d3aecb95b4c4c26a7dffb6d7602a9d9
Autor:
Leo Swadling, Laura J. Pallett, Mariana O. Diniz, Josephine M. Baker, Oliver E. Amin, Kerstin A. Stegmann, Alice R. Burton, Nathalie M. Schmidt, Anna Jeffery-Smith, Nekisa Zakeri, Kornelija Suveizdyte, Farid Froghi, Giuseppe Fusai, William M. Rosenberg, Brian R. Davidson, Anna Schurich, A. Katharina Simon, Mala K. Maini
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 687-698.e6 (2020)
Summary: Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionalit
Externí odkaz:
https://doaj.org/article/424ef329fece490388a8227ae3fca83e
Autor:
Sarah V Williams, Angie Lackenby, Joanna Ellis, Shamez N Ladhani, Leah Thompson, Heather Whitaker, Anna Jeffery-Smith, Thomas A.J. Rowland, Robin Gopal, Rebecca Giddings, Felicity Aiano, Nalini Iyanger, Kevin E. Brown, J. Yimmy Chow, Katja Hoschler, Monika Patel, Mary Ramsay, Maria Zavala, Maria Zambon
Publikováno v:
The Lancet. Healthy Longevity
Summary Background Understanding the duration of protection and risk of reinfection after natural infection is crucial to planning COVID-19 vaccination for at-risk groups, including care home residents, particularly with the emergence of more transmi