Inhibitory Synapse Formation at the Axon Initial Segment

Autor: Anna J. Nathanson, Paul A. Davies, Stephen J. Moss

Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)

The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons and is thus a critical site in the regulation of neuronal excitability. Normal function within the discrete AIS compartment requires intricate molecular ma

Externí odkaz: https://doaj.org/article/3ae1d090d9a84b1c9ef4e7081360f9b7

Phosphorylation on Ser-359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses

Autor: Yasuko Nakamura, Anna J. Nathanson, Stephen J. Moss, Kevin A. Wilkinson, Jeremy M. Henley, Danielle H. Morrow

Publikováno v: Nakamura, Y, Morrow, D H, Nathanson, A J, Henley, J M, Wilkinson, K A & Moss, S J 2020, ' Phosphorylation on Ser-359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses ', Journal of Biological Chemistry, vol. 295, no. 35, pp. 12330-12342 . https://doi.org/10.1074/jbc.RA120.014303

GABA type A receptors (GABAARs) mediate fast synaptic inhibition and are trafficked to functionally diverse synapses. However, the precise molecular mechanisms that regulate the synaptic targeting of these receptors are unclear. Whereas it has been p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26d30c0a31f1214f9b0e36aa775bdc8
https://doi.org/10.1074/jbc.ra120.014303

A Pharmacogenetic ‘Restriction-of-Function’ Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice

Autor: Rachel A. Foster, Benjamin K. Yee, Anna J Nathanson, Elif Engin, Uwe Rudolph, Dietmar Benke, Hanns Ulrich Zeilhofer, Rebecca S. Benham, Jing Liu, Lauren M Behlke

Publikováno v: Neuropsychopharmacology. 41:2492-2501

Benzodiazepines have been widely used for their anxiolytic actions. However, the contribution of GABAA receptor subtypes to anxiolysis is still controversial. Studies with mutant mice harboring diazepam-insensitive α-subunits α1, α2, α3, or α5 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32b51a08cdb0be4453c7be7f1625ce2
https://doi.org/10.1038/npp.2016.49

Developmental seizures and mortality result from reducing GABA

Autor: Rochelle M, Hines, Hans Michael, Maric, Dustin J, Hines, Amit, Modgil, Patrizia, Panzanelli, Yasuko, Nakamura, Anna J, Nathanson, Alan, Cross, Tarek, Deeb, Nicholas J, Brandon, Paul, Davies, Jean-Marc, Fritschy, Hermann, Schindelin, Stephen J, Moss

Publikováno v: Nature Communications

Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABAARs) that are enriched at functionally diverse synapses via mechanisms that remain unclear. Using isothermal titration calorimetry and complementary metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4edb3038c163489f8f5128dfd8846f0
https://pubmed.ncbi.nlm.nih.gov/30087324

Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice

Autor: Joseph F. DeBold, Akiko Shimamoto, Jillian K. Tayeh, Klaus A. Miczek, Elizabeth N. Holly, Anna J. Nathanson, Emily L. Newman, Allison R. Wilens, Lara S. Hwa

Disrupted social behavior, including occasional aggressive outbursts, is characteristic of withdrawal from long-term alcohol (EtOH) use. Heavy EtOH use and exaggerated responses during withdrawal may be treated using glutamatergic N-methyl-D-aspartat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bef89b0b1a4d2040ce344fb26a16155
https://europepmc.org/articles/PMC4515187/