Výsledky vyhledávání - "Anna I Koutsourea"

Steroidal esters of the aromatic nitrogen mustard 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoic acid (2-PHE-BU)

Autor: Anna I. Koutsourea, Georgios N. Pairas, Manolis A. Fousteris, Ioanna C. Papaconstantinou, Athanasios D. Papageorgiou, Sotiris S. Nikolaropoulos

Publikováno v: Anti-Cancer Drugs. 24:52-65

On the basis of the results of in-silico predictions and in an effort to extend our structure-activity relationship studies, the aromatic nitrogen mustard 2-[4-N,N-bis(2-chloroethyl) amino-phenyl]butanoic acid (2-PHE-BU) was synthesized and conjugate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d31445b93b1f8f87de590c4086d50a
https://doi.org/10.1097/cad.0b013e328357f687

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Cytogenetic and antineoplastic effects by newly synthesised steroidal alkylators in lymphocytic leukaemia P388 cells in vivo

Autor: Dimitra Kareli, E. Dafa, Manolis A. Fousteris, George Pairas, Th. Lialiaris, Maria Argyraki, C. Mourelatos, Anna I. Koutsourea, S.S. Nikolaropoulos, I. Papakonstantinou

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 746:1-6

New compounds with potential antitumour activity were synthesised by combining nitrogen mustard with the steroidal skeleton, in an effort to improve specificity and at the same time reduce systemic toxicity. The steroidal part is aimed to serve as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2b9cc62a2658809142b97e5ef20b7a
https://doi.org/10.1016/j.mrgentox.2011.12.032

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Cytogenetic and Antineoplastic Effects of Modified Steroidal Alkylators

Autor: Sotiris S. Nikolaropoulos, George Pairas, Manolis A. Fousteris, Denis Mourelatos, T. Lialiaris, Anna I. Koutsourea, Irini Karapidaki, George D. Geromichalos, Athanasios A. Papageorgiou, Ioanna Papaconstadinou

Publikováno v: Genetic Testing and Molecular Biomarkers. 14:93-97

The aim of this study was to design new potentially antineoplastic agents by combining nitrogen mustard with steroidal skeleton, in an effort to improve specificity and simultaneously to reduce systemic toxicity. The steroidal part is aimed to act as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94af2c5e73adce2f22a0389cc8c4228f
https://doi.org/10.1089/gtmb.2009.0059

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Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters

Autor: Evagelia S. Arsenou, George Pairas, Manolis A. Fousteris, Anna I. Koutsourea, Sotiris S. Nikolaropoulos, Athanasios A. Papageorgiou

Publikováno v: Bioorganic & Medicinal Chemistry. 16:5207-5215

The synthesis and the in vivo evaluation against leukemias P388 and L1210 of six new alkylating steroidal esters are described. The esteric derivatives incorporating the 17β-acetamido-B-lactamic steroidal skeleton exhibited increased antileukemic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a039c288dea57edf9c41831b264fc46
https://doi.org/10.1016/j.bmc.2008.03.015

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Pyrrolo[2,3-a]carbazoles as Potential Cyclin Dependent Kinase 1 (CDK1) Inhibitors. Synthesis, Biological Evaluation, and Binding Mode through Docking Simulations

Autor: Maria Manioudaki, Manolis A. Fousteris, Evgenia Lampropoulou, Georgios A. Spyroulias, Evangelia Papadimitriou, Athanasios Papakyriakou, Sotiris S. Nikolaropoulos, Anna I. Koutsourea

Publikováno v: Journal of Medicinal Chemistry. 51:1048-1052

Pyrrolo[2,3- a]carbazole derivatives were synthesized, and their effects on CDK1/cyclinB activity were evaluated. The most potent and efficacious inhibitor was found to be ethyl 9-chloro-1H-pyrrolo[2,3-alpha]carbazole-2-carboxylate (1e), exhibiting a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25474a3f41d7681b1ab9c285c2fe8cca
https://doi.org/10.1021/jm0700666

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Antileukemic and Cytogenetic Activity by Triple Administration of Three Modified Steroidal Derivatives of Nitrogen Mustards

Autor: D.O. Onyango, S.S. Nikolaropoulos, Anna I. Koutsourea, Athanasios A. Papageorgiou, Evaggelia S. Arsenou, Dionysios Mourelatos, Manolis A. Fousteris, E. Karaberis

Publikováno v: Chemotherapy. 53:118-126

Combination chemotherapy is widely and routinely used for most cancer patients. The main objective of this study is an effort to develop new anticancer drugs and procedures with enhanced antitumor activity and reduced toxicity. This study was designe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303de94dae7f47041964b4fa1695e1f
https://doi.org/10.1159/000099983

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Rational Design, Synthesis and In Vitro Evaluation of Three New Alkylating Steroidal Esters

Autor: Manolis A. Fousteris, Evaggelia S. Arsenou, Anna I. Koutsourea, S.S. Nikolaropoulos, Dionysios Mourelatos, N. P. Lagonikakos, C. Spyridonidou

Publikováno v: Medicinal Chemistry. 2:569-576

Recent studies have indicated that minor functional changes on the steroidal part of complex molecules, comprising of an alkylating moiety and a steroidal congener, lead to compounds with enhanced biological activity. The observed induction of the ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f207f3a8c00578357432b05e8b6569
https://doi.org/10.2174/1573406410602060569

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Improved chromium-catalyzed allylic oxidation of Δ5-steroids with t-butyl hydroperoxide

Autor: Anna I. Koutsourea, Manolis A. Fousteris, Sotiris S. Nikolaropoulos, Abdelkhalek Riahi, Jacques Muzart

Publikováno v: Journal of Molecular Catalysis A: Chemical. 250:70-74

Various chromium VI -catalyzed conditions have been tested to improve the oxidation of Δ 5 -steroids with t -BuOOH to their corresponding 5-en-7-ones. The use of PDC or the association of CrO 3 with an amine as the catalyst and CH 2 Cl 2 or PhCF 3 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7262945a027e6ee405083e8477e0ae4
https://doi.org/10.1016/j.molcata.2006.01.031

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The allylic 7-ketone at the steroidal skeleton is crucial for the antileukemic potency of chlorambucil’s active metabolite steroidal esters

Autor: Manolis A. Fousteris, Zafiria Iakovidou, E. Mioglou, Sotiris S. Nikolaropoulos, Athanasios A. Papageorgiou, Dionysios Mourelatos, Evaggelia S. Arsenou, Anna I. Koutsourea, Venetia Karayianni

Publikováno v: Anti-Cancer Drugs. 15:983-990

We have investigated the role of the allylic 7-ketone in oxidized Delta5-steroids on antileukemic activity. We synthesized and studied a series of oxidized and non-oxidized steroidal esters of p-N,N-bis(2-chloroethyl)aminophenylacetic acid (PHE), chl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c6714eb43d706f03fbf8c7b9dd82cb
https://doi.org/10.1097/00001813-200411000-00008

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Pyrrolocarbazole analogs of aromatic skeleton of indolocarbazole natural products

Autor: Evaggelia S. Arsenou, L. Leondiadis, Manolis A. Fousteris, Anna I. Koutsourea, Ioannis K. Stamos, Sotiris S. Nikolaropoulos

Publikováno v: Journal of Heterocyclic Chemistry. 41:349-353

The synthesis of seven pyrrolo[2,3-a]carbazoles derivatives using Fischer indole cyclization conditions is described. Polyphosphoric acid trimethylsilyl ester was used as a mild catalyst for the cyclization step of intermediate arylhydrazones which w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::081966b8c9b7af6208caaae0842f75e9
https://doi.org/10.1002/jhet.5570410307

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