Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Anna Huttenlocher"'
Autor:
Chao Li, Mehtab Farooqui, Ravi Chandra Yada, Joseph B. Cai, Anna Huttenlocher, David J. Beebe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract While the exquisite sensitivity of neutrophils enables their rapid response to infection in vivo; this same sensitivity complicates the ex vivo study of neutrophils. Handling of neutrophils ex vivo is fraught with unwanted heterogeneity and
Externí odkaz:
https://doaj.org/article/5375a55c664145d68deba4b3d7d68e38
Autor:
Kehinde Adebayo Babatunde, Rupsa Datta, Nathan W. Hendrikse, Jose M. Ayuso, Anna Huttenlocher, Melissa C. Skala, David J. Beebe, Sheena C. Kerr
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110632- (2024)
Summary: The tumor microenvironment (TME) is characterized by a network of cancer cells, recruited immune cells, and extracellular matrix (ECM). However, the specific role of neutrophils during tumor development, and their interactions with other imm
Externí odkaz:
https://doaj.org/article/f7d54eb5b2a349b387ba54a749533678
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109532- (2024)
Summary: Wound healing is impaired by infection; however, how microbe-induced inflammation modulates tissue repair remains unclear. We took advantage of the optical transparency of zebrafish and a genetically tractable microbe, Listeria monocytogenes
Externí odkaz:
https://doaj.org/article/1f7e2c76438f40779d2cde0cb1d6f736
Autor:
Adriana A. de Jesus, Guibin Chen, Dan Yang, Tomas Brdicka, Natasha M. Ruth, David Bennin, Dita Cebecauerova, Hana Malcova, Helen Freeman, Neil Martin, Karel Svojgr, Murray H. Passo, Farzana Bhuyan, Sara Alehashemi, Andre T. Rastegar, Katsiaryna Uss, Lela Kardava, Bernadette Marrero, Iris Duric, Ebun Omoyinmi, Petra Peldova, Chyi-Chia Richard Lee, David E. Kleiner, Colleen M. Hadigan, Stephen M. Hewitt, Stefania Pittaluga, Carmelo Carmona-Rivera, Katherine R. Calvo, Nirali Shah, Miroslava Balascakova, Danielle L. Fink, Radana Kotalova, Zuzana Parackova, Lucie Peterkova, Daniela Kuzilkova, Vit Campr, Lucie Sramkova, Angelique Biancotto, Stephen R. Brooks, Cameron Manes, Eric Meffre, Rebecca L. Harper, Hyesun Kuehn, Mariana J. Kaplan, Paul Brogan, Sergio D. Rosenzweig, Melinda Merchant, Zuoming Deng, Anna Huttenlocher, Susan L. Moir, Douglas B. Kuhns, Manfred Boehm, Karolina Skvarova Kramarzova, Raphaela Goldbach-Mansky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases. Here the authors report a case series of three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation, and i
Externí odkaz:
https://doaj.org/article/ae467ac9fc384475ae6d8259f8ad7971
Autor:
Taylor J Schoen, Dante G Calise, Jin Woo Bok, Morgan A Giese, Chibueze D Nwagwu, Robert Zarnowski, David Andes, Anna Huttenlocher, Nancy P Keller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011152 (2023)
Hyphal growth is essential for host colonization during Aspergillus infection. The transcription factor ZfpA regulates A. fumigatus hyphal development including branching, septation, and cell wall composition. However, how ZfpA affects fungal growth
Externí odkaz:
https://doaj.org/article/54b4ec096f514a7f8c91391b1326d8c7
Autor:
Peter Dieterich, Otto Lindemann, Mats Leif Moskopp, Sebastien Tauzin, Anna Huttenlocher, Rainer Klages, Aleksei Chechkin, Albrecht Schwab
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010089 (2022)
The motility of neutrophils and their ability to sense and to react to chemoattractants in their environment are of central importance for the innate immunity. Neutrophils are guided towards sites of inflammation following the activation of G-protein
Externí odkaz:
https://doaj.org/article/d7ddae628dd54a7493c3efcc3bf6511b
Autor:
Benjamin G. Korte, Morgan A. Giese, Gayathri Ramakrishnan, Stella Ma, David Bennin, Julie Rindy, Colin N. Dewey, Anna Huttenlocher
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Neutrophils in the tumor microenvironment exhibit altered functions. However, the changes in neutrophil behavior during tumor initiation remain unclear. Here we used Translating Ribosomal Affinity Purification (TRAP) and RNA sequencing to identify ne
Externí odkaz:
https://doaj.org/article/ede9b05827824af7968f97b36a214a20
Autor:
Veronika Miskolci, Kelsey E Tweed, Michael R Lasarev, Emily C Britt, Alex J Walsh, Landon J Zimmerman, Courtney E McDougal, Mark R Cronan, Jing Fan, John-Demian Sauer, Melissa C Skala, Anna Huttenlocher
Publikováno v:
eLife, Vol 11 (2022)
The function of macrophages in vitro is linked to their metabolic rewiring. However, macrophage metabolism remains poorly characterized in situ. Here, we used two-photon intensity and lifetime imaging of autofluorescent metabolic coenzymes, nicotinam
Externí odkaz:
https://doaj.org/article/8206c968188744b0808bd43cb3275c27
Autor:
Vera S. Brok-Volchanskaya, David A. Bennin, Kran Suknuntha, Lucas C. Klemm, Anna Huttenlocher, Igor Slukvin
Publikováno v:
Stem Cell Reports, Vol 13, Iss 6, Pp 1099-1110 (2019)
Summary: Human induced pluripotent stem cells (hiPSCs) can serve as a versatile and scalable source of neutrophils for biomedical research and transfusion therapies. Here we describe a rapid efficient serum- and xenogen-free protocol for neutrophil g
Externí odkaz:
https://doaj.org/article/952f06d748934f86b9b00eaabca88245
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
During infection, neutrophils are the most abundantly recruited innate immune cells at sites of infection, playing critical roles in the elimination of local infection and healing of the injury. Neutrophils are considered to be short-lived effector c
Externí odkaz:
https://doaj.org/article/8b502aa1b895440dbf8c353de02d5fb8