Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Anna Hutchinson"'
Autor:
Celia Alda-Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Bin Sun, William Pembroke, Sebastian Ullrich, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Background Drug targets with genetic evidence are expected to increase clinical success by at least twofold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of drug discovery. A
Externí odkaz:
https://doaj.org/article/c304ef90e9444591bb08261355ae7dd1
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Genome-wide association studies (GWAS) are limited in power to detect associations that exceed the stringent genome-wide significance threshold. This limitation can be alleviated by leveraging relevant auxiliary data, such as func
Externí odkaz:
https://doaj.org/article/9ca130b5f24c4851bcdd5a586ce4b751
Autor:
Christophe Bourges, Abigail F Groff, Oliver S Burren, Chiara Gerhardinger, Kaia Mattioli, Anna Hutchinson, Theodore Hu, Tanmay Anand, Madeline W Epping, Chris Wallace, Kenneth GC Smith, John L Rinn, James C Lee
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp 1-17 (2020)
Abstract Deriving mechanisms of immune‐mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently hampered by strong linkage disequilibrium. To determine whether causal variants could
Externí odkaz:
https://doaj.org/article/6f6d2d05ba2f4f178954073cc994019a
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009853 (2021)
Genome-wide association studies (GWAS) have identified thousands of genetic variants that are associated with complex traits. However, a stringent significance threshold is required to identify robust genetic associations. Leveraging relevant auxilia
Externí odkaz:
https://doaj.org/article/93eb8dbb93eb4685b6d8293ba0b38246
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007829 (2020)
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated with human diseases. Bayesian genetic fine-mapping studies aim to identify the specific causal variants within GWAS loci responsible for each association
Externí odkaz:
https://doaj.org/article/940b9276e7524bc59db9873bd37b5e09
Autor:
Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S. Steed, Rajan D. Adhikari, Jonathan J. Wisco, Bre Anna Hutchinson
Publikováno v:
European Journal of Neuroscience. 57:1033-1047
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9939df27ba8be7954b9b952b1c804d
https://doi.org/10.1111/ejn.15933
https://doi.org/10.1111/ejn.15933
Autor:
Celia Alda Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Drug targets with human genetic evidence are expected to increase clinical success by at least two-fold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of early drug discovery. A key iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c18edd229f5eeebe62906e7c14bea9b
https://doi.org/10.1101/2023.05.14.540711
https://doi.org/10.1101/2023.05.14.540711
Autor:
Sueh-li Lim, John Reynolds, Hang Quach, Anna Hutchinson, Ian H Kerridge, Jane Estell, Craig wallington-Gates, Anna Kalff, Flora Yuen, Andrew Spencer
Publikováno v:
Blood. 140:10174-10176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2288614343cf7b7743f5a330fbd4b81b
https://doi.org/10.1182/blood-2022-170697
https://doi.org/10.1182/blood-2022-170697
Autor:
null Elisabeth Black, null Abbey Rasch, null Tyler Wimmer, null Alivia Li, null Amanda Araujo, null Steve Cieslak, null Kevin S. Steed, null Rajan D. Adhikari, null Jonathan J. Wisco, null Bre Anna Hutchinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f066801fb82c609c2de3ed39a1d5795
https://doi.org/10.1111/ejn.15933/v2/response1
https://doi.org/10.1111/ejn.15933/v2/response1
Autor:
Jan A. Yow, Brett A. Criswell, Christine Lotter, Wendy M. Smith, Gregory T. Rushton, Paula Adams, Sally Ahrens, Anna Hutchinson, Greysi Irdam
Publikováno v:
International Journal of Leadership in Education. :1-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015e5f0c208b8806aec8fb178259c5c8
https://doi.org/10.1080/13603124.2021.2006794
https://doi.org/10.1080/13603124.2021.2006794