Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Anna Huguet Ninou"'
Autor:
Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhib
Externí odkaz:
https://doaj.org/article/a5be37faa19d4d1fbbb9c428f096c524
Autor:
Jos Jonkers, Anna Huguet Ninou, Emma Åkerlund, Ulrika Joneborg, Dimitrios Chioureas, Joseph W. Carlson, Brinton Seashore-Ludlow, Hannah Stigsdotter, Korbinian Schelzig, Nina M. S. Gustafsson, Greta Gudoityte, Jemina Lehto
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3604, p 3604 (2021)
Cancers; Volume 13; Issue 14; Pages: 3604
Cancers, Vol 13, Iss 3604, p 3604 (2021)
Cancers; Volume 13; Issue 14; Pages: 3604
Simple Summary DNA-damaging chemotherapeutics, such as platinum drugs, are cornerstones in cancer treatment. The efficacy of such treatment is intimately linked to the DNA repair capacity of the cancer cells, as DNA damage above a tolerable threshold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0760a1448b21e23da4e0b92d08fb949e
http://europepmc.org/articles/PMC8306909
http://europepmc.org/articles/PMC8306909
Publikováno v:
Cancers
Volume 13
Issue 6
Cancers, Vol 13, Iss 1442, p 1442 (2021)
Volume 13
Issue 6
Cancers, Vol 13, Iss 1442, p 1442 (2021)
Simple Summary Chemotherapeutics exerting their antiproliferative actions by introducing DNA crosslinks, such as platinum drugs, are used to treat numerous cancers. Unfortunately, their therapeutic potential is limited due to adverse side effects and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86cf73fa0b000013057a594cfdc7e54
Autor:
Jessica Hollers, Martin Norin, Katarina Färnegårdh, Jemina Lehto, Nadilly Bonagas, N. Markova, Carina Norström, Anna Huguet Ninou, Petra Groth, Nina M. S. Gustafsson, Martin Andersson, Jessica Martinsson, Baek Kim, Elisee Wiita, Rosa Pennisi, Thomas Olin, Kenth Hallberg, Johan Schultz, Mattias Jönsson, Petra Marttila, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ea467c334b76d93f503c7eee3f7fb8
