Phospho‐tyrosine dependent protein–protein interaction network

Autor: Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl

Publikováno v: Molecular Systems Biology, Vol 11, Iss 3, Pp 1-14 (2015)

Abstract Post‐translational protein modifications, such as tyrosine phosphorylation, regulate protein–protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two‐hybrid system employi

Externí odkaz: https://doaj.org/article/5064d016645c4e3bb83d8ffde1df14a5

The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage

Autor: Gyula Timinszky, Sébastien Huet, Catherine Chapuis, Hari R. Singh, Rebecca Smith, Hafida Sellou, M. Kozlowski, Andreas G. Ladurner, Sebastian Bultmann, Théo Lebeaupin, Anna Hegele

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2016, 27 (24), pp.3791-3799. ⟨10.1091/mbc.E16-05-0269⟩
Molecular Biology of the Cell, 2016, 27 (24), pp.3791-3799. ⟨10.1091/mbc.E16-05-0269⟩

PARP1 and its effector, the ATP-dependent chromatin remodeler Alc1/Chd1L, are identified as key players during the rapid chromatin relaxation at DNA damage sites.
Chromatin relaxation is one of the earliest cellular responses to DNA damage. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79562d9b99a4ad9b7c19ddfc750706c0
https://pubmed.ncbi.nlm.nih.gov/27733626

A stringent yeast two-hybrid matrix screening approach for protein-protein interaction discovery

Autor: Josephine M, Worseck, Arndt, Grossmann, Mareike, Weimann, Anna, Hegele, Ulrich, Stelzl

Publikováno v: Methods in molecular biology (Clifton, N.J.). 812

The yeast two-hybrid (Y2H) system is currently one of the most important techniques for protein-protein interaction (PPI) discovery. Here, we describe a stringent three-step Y2H matrix interaction approach that is suitable for systematic PPI screenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8344f3a82fa8c16a3b98de55e913657
https://pubmed.ncbi.nlm.nih.gov/22218854

Large-scale De Novo Prediction of Physical Protein-Protein Association*

Autor: Antigoni Elefsinioti, Ulrich Stelzl, Michael Schroeder, Conrad Plake, Mihail Sarov, Anthony A. Hyman, Matthias Mann, Anna Hegele, Omer Sinan Sarac, Andreas Beyer, Ina Poser, Nina C. Hubner

Publikováno v: Molecular & Cellular Proteomics; Vol 10

Information about the physical association of proteins is extensively used for studying cellular processes and disease mechanisms. However, complete experimental mapping of the human interactome will remain prohibitively difficult in the near future.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3b33fe60ae1e061ac870fa383857f6

Phospho-tyrosine dependent protein-protein interaction network.

Autor: Grossmann, Arndt¹, Benlasfer, Nouhad¹, Birth, Petra¹, Hegele, Anna¹, Wachsmuth, Franziska¹, Apelt, Luise¹, Stelzl, Ulrich¹

Publikováno v: Molecular Systems Biology. Mar2015, Vol. 11 Issue 3, pn/a-N.PAG. 14p.