Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Anna Haduch"'
Publikováno v:
Metabolites, Vol 13, Iss 5, p 629 (2023)
Tryptophan is metabolized along three main metabolic pathways, namely the kynurenine, serotonin and indole pathways. The majority of tryptophan is transformed via the kynurenine pathway, catalyzed by tryptophan-2,3-dioxygenase or indoleamine-2,3-diox
Externí odkaz:
https://doaj.org/article/3c99b56064c24a468bca04d62379436c
Autor:
Ewa Bromek, Anna Haduch, Marta Rysz, Joanna Jastrzębska, Renata Pukło, Olga Wójcikowska, Przemysław Jan Danek, Władysława Anna Daniel
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1643 (2021)
Recent research indicates that selective NMDA receptor GluN2B subunit antagonists may become useful for the treatment of major depressive disorders. We aimed to examine in parallel the effect of the selective NMDA receptor GluN2B subunit antagonist C
Externí odkaz:
https://doaj.org/article/8d90baaf32da49e78413385ceca134eb
Autor:
Anna Haduch, Ewa Bromek, Renata Pukło, Joanna Jastrzębska, Przemysław Jan Danek, Władysława Anna Daniel
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13746
The CYP2D enzymes of the cytochrome P450 superfamily play an important role in psychopharmacology, since they are engaged in the metabolism of psychotropic drugs and endogenous neuroactive substrates, which mediate brain neurotransmission and the the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3a5541260e63e63792e04a696e3461
Autor:
Renata Pukło, Magdalena Łasoń, Władysława A. Daniel, Mariusz Papp, Ewa Bromek, Anna Haduch, Marta Rysz, Monika Niemczyk, Piotr Gruca
Publikováno v:
Pharmacological Reports
Background The aim of our research was to determine the effects of chronic treatment with the atypical antidepressant agomelatine on the expression and activity of liver cytochrome P450 (CYP) in the chronic mild stress (CMS) model of depression, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2216ae0df0c5f2929d8d75e05337bb41
https://doi.org/10.1007/s43440-020-00151-w
https://doi.org/10.1007/s43440-020-00151-w
Publikováno v:
Biochemical Pharmacology. 199:115006
Cytochrome P450 (CYP) plays an important role in psychopharmacology. While liver CYP enzymes are responsible for the biotransformation of psychotropic drugs, brain CYP enzymes are involved in the local metabolism of these drugs and endogenous neuroac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c997048123696afdc197a7de1c249d
https://doi.org/10.1016/j.bcp.2022.115006
https://doi.org/10.1016/j.bcp.2022.115006
Autor:
Michael Bader, Agnieszka Nikiforuk, Anna Haduch, Renata Pukło, Piotr Popik, Natalia Alenina, Władysława A. Daniel
Publikováno v:
Neurochemistry international. 141
Brain cytochrome P450 (CYP) contributes to the local metabolism of endogenous substrates and drugs. The aim of present study was to ascertain whether the cytochrome P450 2D (CYP2D) activity changes with ageing and in cerebral serotonin deficit. Kinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5205c721344f77a520e1af5aa2774787
https://pubmed.ncbi.nlm.nih.gov/33091481
https://pubmed.ncbi.nlm.nih.gov/33091481
Publikováno v:
Drug Metabolism and Disposition. 47:80-85
Our recent study carried out after local injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine into the arcuate nucleus (ARC) of the hypothalamus suggested a positive influence of the serotonergic innervation of the ARC on growth hormone (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f42630cd6b5a44598f51e236b8e442e
https://doi.org/10.1124/dmd.118.083808
https://doi.org/10.1124/dmd.118.083808
Publikováno v:
Drug Metabolism and Disposition. 46:786-793
Our recent work suggested a negative effect for the serotonergic innervation of the paraventricular nuclei (PVN) of the hypothalamus on growth hormone secretion and growth hormone-dependent expression of CYP2C11. The aim of our present research was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1157506994b1bf137d22cc6bd0cf7249
https://doi.org/10.1124/dmd.117.079632
https://doi.org/10.1124/dmd.117.079632
Publikováno v:
Pharmacological Reports. 71:1210-1212
Background Our previous study has demonstrated that activation of the 5-HT2, but not 5-HT1 serotonin receptor type in the hypothalamic arcuate nucleus (ARC) is responsible for the neuroendocrine regulation of liver cytochrome P450. The goal of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51fd29346e06dd445411bb5fbc3f7f2
https://doi.org/10.1016/j.pharep.2019.05.010
https://doi.org/10.1016/j.pharep.2019.05.010
Autor:
Natalia Alenina, Władysława A. Daniel, Renata Pukło, Michael Bader, Wojciech Kuban, Anna Haduch, Joanna Golebiowska, Piotr Popik, Przemysław J Danek
Publikováno v:
Neurochemistry International. 152:105223
Among the enzymes that support brain metabolism, cytochrome P450 (CYP) enzymes occupy an important place. These enzymes catalyze the biotransformation pathways of neuroactive endogenous substrates (neurosteroids, neurotransmitters) and are necessary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdd0872d73e3cf965ef44befa16c0d3
https://doi.org/10.1016/j.neuint.2021.105223
https://doi.org/10.1016/j.neuint.2021.105223