Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Anna Grosberg"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8, p e1012321 (2024)
Understanding muscle contraction mechanisms is a standing challenge, and one of the approaches has been to create models of the sarcomere-the basic contractile unit of striated muscle. While these models have been successful in elucidating many aspec
Externí odkaz:
https://doaj.org/article/bc94db2e1c9f4a1cb3c8e634b9fe0ef9
Autor:
Michael V. Zaragoza, Thuy-Anh Bui, Halida P. Widyastuti, Mehrsa Mehrabi, Zixuan Cang, Yutong Sha, Anna Grosberg, Qing Nie
Publikováno v:
Cells, Vol 13, Iss 17, p 1479 (2024)
LMNA-related dilated cardiomyopathy (DCM) is an autosomal-dominant genetic condition with cardiomyocyte and conduction system dysfunction often resulting in heart failure or sudden death. The condition is caused by mutation in the Lamin A/C (LMNA) ge
Externí odkaz:
https://doaj.org/article/1efb3d9dd63c4066b6f6d3c3912884ad
Autor:
Anicca D. Harriot, Tessa Altair Morris, Camilo Vanegas, Jacob Kallenbach, Kaylie Pinto, Humberto C. Joca, Marie-Jo Moutin, Guoli Shi, Jeanine A. Ursitti, Anna Grosberg, Christopher W. Ward
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Altered myofibrillar structure is a consequence of dystrophic pathology that impairs skeletal muscle contractile function and increases susceptibility to contraction injury. In murine Duchenne muscular dystrophy (mdx), myofibrillar alterations are ab
Externí odkaz:
https://doaj.org/article/a51700562a7c4ab8a3cb96c40aeb52a0
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Obstructive sleep apnea (OSA) is a sleep disorder caused by periodic airway obstructions and has been associated with numerous health consequences, which are thought to result from tissue hypoxia. However, challenges in the direct measurement of tiss
Externí odkaz:
https://doaj.org/article/e89e879e54424919aae66807f347b559
Autor:
Arkaprabha Basu, Manash K. Paul, Mitchel Alioscha-Perez, Anna Grosberg, Hichem Sahli, Steven M. Dubinett, Shimon Weiss
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A computational method for automated quantification of actin stress fiber alignment in fluorescence images of cultured cells is presented, used to detect changes in stress fiber organization during EMT, with pathways regulating actin dynamics manipul
Externí odkaz:
https://doaj.org/article/7ca65a79d5344b26bb93b4164b09418c
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Intermediate filament proteins that construct the nuclear lamina of a cell include the Lamin A/C proteins encoded by the LMNA gene, and are implicated in fundamental processes such as nuclear structure, gene expression, and signal
Externí odkaz:
https://doaj.org/article/f303372996574dc4a390ff8bd741c43f
Publikováno v:
Frontiers in Physics, Vol 8 (2021)
Understanding force propagation through the fibrous extracellular matrix can elucidate how cells interact mechanically with their surrounding tissue. Presumably, due to elastic nonlinearities of the constituent filaments and their random connection t
Externí odkaz:
https://doaj.org/article/8fd76ecda5e141328cb6562b84d8ea15
Autor:
William Sherman, Anna Grosberg
Publikováno v:
AIP Advances, Vol 10, Iss 4, Pp 045126-045126-11 (2020)
While the fundamental steps outlining myofibril formation share a similar scheme for different cell and species types, various granular details involved in the development of a functional contractile muscle are not well understood. Many studies of my
Externí odkaz:
https://doaj.org/article/78e33f5ee029494287dda9db530053ca
Autor:
Tessa Altair Morris, Jasmine Naik, Kirby Sinclair Fibben, Xiangduo Kong, Tohru Kiyono, Kyoko Yokomori, Anna Grosberg
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 3, p e1007676 (2020)
As sarcomeres produce the force necessary for contraction, assessment of sarcomere order is paramount in evaluation of cardiac and skeletal myocytes. The uniaxial force produced by sarcomeres is ideally perpendicular to their z-lines, which couple pa
Externí odkaz:
https://doaj.org/article/beacb195ced145cc8e99f0168819d63e
Autor:
Richard Duc Hien Tran, Tessa Altair Morris, Daniela Gonzalez, Ali Hatem Salaheldin Hassan Ahmed Hetta, Anna Grosberg
Publikováno v:
Cells, Vol 10, Iss 11, p 3199 (2021)
The heart has a dynamic mechanical environment contributed by its unique cellular composition and the resultant complex tissue structure. In pathological heart tissue, both the mechanics and cell composition can change and influence each other. As a
Externí odkaz:
https://doaj.org/article/22261ae217ab43078f7ab74e0860efd7