Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Anna Greka"'
Autor:
Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Amanda Kotek, Giorgio Trivioli, Nathan Richoz, Mary B. Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114253- (2024)
Summary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profile
Externí odkaz:
https://doaj.org/article/c26ba69a6afe47bdbc7deb8408bb9ad1
Autor:
Stefano Suzzi, Tommaso Croese, Adi Ravid, Or Gold, Abbe R. Clark, Sedi Medina, Daniel Kitsberg, Miriam Adam, Katherine A. Vernon, Eva Kohnert, Inbar Shapira, Sergey Malitsky, Maxim Itkin, Alexander Brandis, Tevie Mehlman, Tomer M. Salame, Sarah P. Colaiuta, Liora Cahalon, Michal Slyper, Anna Greka, Naomi Habib, Michal Schwartz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit
Externí odkaz:
https://doaj.org/article/f63e1c3be52546e8ab1f362761e300d0
Autor:
Sung-Hee Yoon, Mark B. Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S. Wang, Christian D. Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A. Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B. Sundberg, Ramnik J. Xavier, Charles H. Adelmann, Daniel J. Brooks, Anthony Anselmo, Ruslan I. Sadreyev, Ivy A. Rosales, David E. Fisher, Navin Gupta, Ryuji Morizane, Anna Greka, J. Wesley Pike, Michael Mannstadt, Marc N. Wein
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated
Externí odkaz:
https://doaj.org/article/807eb29db7bc4680b7215fddd31857a3
Autor:
Ahmad Halawi, Abdullah B. El Kurdi, Katherine A. Vernon, Zhabiz Solhjou, John Y. Choi, Anis J. Saad, Nour K. Younis, Rania Elfekih, Mostafa Tawfeek Mohammed, Christa A. Deban, Astrid Weins, Reza Abdi, Leonardo V. Riella, Sasha A. De Serres, Paolo Cravedi, Anna Greka, Pierre Khoueiry, Jamil R. Azzi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundKidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying
Externí odkaz:
https://doaj.org/article/06800a222d9a45f781483d981d3fc496
Autor:
Jamie L. Marshall, Teia Noel, Qingbo S. Wang, Haiqi Chen, Evan Murray, Ayshwarya Subramanian, Katherine A. Vernon, Silvana Bazua-Valenti, Katie Liguori, Keith Keller, Robert R. Stickels, Breanna McBean, Rowan M. Heneghan, Astrid Weins, Evan Z. Macosko, Fei Chen, Anna Greka
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104097- (2022)
Summary: High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionable pathways remains unexplored. We appl
Externí odkaz:
https://doaj.org/article/d6f6c8d314e2467b847da7b75df23eaa
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Spatial transcriptomic technologies capture genome-wide readouts across biological tissue space. Moreover, recent advances in this technology, including Slide-seqV2, have achieved spatial transcriptomic data collection at a near-single cell resolutio
Externí odkaz:
https://doaj.org/article/22e0500255bb427b9dbaec1815dca725
Autor:
Ayshwarya Subramanian, Eriene-Heidi Sidhom, Maheswarareddy Emani, Katherine Vernon, Nareh Sahakian, Yiming Zhou, Maria Kost-Alimova, Michal Slyper, Julia Waldman, Danielle Dionne, Lan T. Nguyen, Astrid Weins, Jamie L. Marshall, Orit Rosenblatt-Rosen, Aviv Regev, Anna Greka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition i
Externí odkaz:
https://doaj.org/article/fec9d1d79cc3436c8e6951c9b267d13d
Autor:
Yiming Zhou, Choah Kim, Juan Lorenzo B. Pablo, Fan Zhang, Ji Yong Jung, Li Xiao, Silvana Bazua-Valenti, Maheswarareddy Emani, Corey R. Hopkins, Astrid Weins, Anna Greka
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease
Externí odkaz:
https://doaj.org/article/63a32a6e578a4a1fb96f6f3d356e4283
Autor:
Howard Trachtman, Debbie S. Gipson, Michael Somers, Cathie Spino, Sharon Adler, Lawrence Holzman, Jeffrey B. Kopp, John Sedor, Sandra Overfield, Ayanbola Elegbe, Michael Maldonado, Anna Greka
Publikováno v:
Kidney International Reports, Vol 3, Iss 1, Pp 115-121 (2018)
Treatment-resistant nephrotic syndrome is a rare form of glomerular disease that occurs in children and adults. No Food and Drug Administration−approved treatments consistently achieve remission of proteinuria and preservation of kidney function. C
Externí odkaz:
https://doaj.org/article/bd5442e268724865b35f5bd56da99dd6
Autor:
Li Xiao, Xiaoxuan Xu, Fan Zhang, Ming Wang, Yan Xu, Dan Tang, Jiahui Wang, Yan Qin, Yu Liu, Chengyuan Tang, Liyu He, Anna Greka, Zhiguang Zhou, Fuyou Liu, Zheng Dong, Lin Sun
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 297-311 (2017)
Mitochondria play a crucial role in tubular injury in diabetic kidney disease (DKD). MitoQ is a mitochondria-targeted antioxidant that exerts protective effects in diabetic mice, but the mechanism underlying these effects is not clear. We demonstrate
Externí odkaz:
https://doaj.org/article/a8cb6a3cfccd4cbea99c0ddac363dfda