In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates

Autor: Alessandro Giuliani, Anna Giulia Balducci, Elisa Zironi, Gaia Colombo, Fabrizio Bortolotti, Luca Lorenzini, Viola Galligioni, Giampiero Pagliuca, Alessandra Scagliarini, Laura Calzà, Fabio Sonvico

Publikováno v: Drug Delivery, Vol 25, Iss 1, Pp 376-387 (2018)

Nasal administration has been proposed as a potential approach for the delivery of drugs to the central nervous system. Ribavirin (RBV), an antiviral drug potentially useful to treat viral infections both in humans and animals, has been previously de

Externí odkaz: https://doaj.org/article/0fab718143944a08b4e8b098aa14ec46

Engineered sodium hyaluronate respirable dry powders for pulmonary drug delivery

Autor: Anna Giulia Balducci, Francesco Martinelli, Ben Forbes, Fabio Sonvico, Abhinav Kumar, Ruggero Bettini, Francesca Buttini

Publikováno v: Martinelli, F, Balducci, A G, Kumar, A, Sonvico, F, Forbes, B, Bettini, R & Buttini, F 2017, ' Engineered sodium hyaluronate respirable dry powders for pulmonary drug delivery ', INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 517, no. 1-2, pp. 286-295 . https://doi.org/10.1016/j.ijpharm.2016.12.002

Sodium hyaluronate (HYA) warrants attention as a material for inhalation due to its (i) therapeutic potential, (ii) utility as a formulation excipient or drug carrier, and (iii) ability to target lung inflammation and cancer. This study aimed to over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bcfdba7b1cfd9d87c4e11a0cd10665
https://doi.org/10.1016/j.ijpharm.2016.12.002

Multivariate Analysis of Effects of Asthmatic Patient Respiratory Profiles on the In Vitro Performance of a Reservoir Multidose and a Capsule-Based Dry Powder Inhaler

Autor: Anna Giulia Balducci, Viviana Sisti, Pasquali Irene, Ruggero Bettini, Massimiliano Dagli Alberi, Diego Copelli, Francesca Buttini, Gaetano Brambilla

Publikováno v: Pharmaceutical Research

Purpose The aim of this work was to evaluate the effect of two different dry powder inhalers, of the NGI induction port and Alberta throat and of the actual inspiratory profiles of asthmatic patients on in-vitro drug inhalation performances. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de4aefa8680045895f083169415f7d5
http://europepmc.org/articles/PMC4744254

Polymeric Films Loaded with Vitamin E andAloe verafor Topical Application in the Treatment of Burn Wounds

Autor: Gabriela Garrastazu Pereira, Sílvia Stanisçuaki Guterres, Paolo Colombo, Fabio Sonvico, Anna Giulia Balducci

Publikováno v: BioMed Research International
BioMed Research International, Vol 2014 (2014)

Burns are serious traumas related to skin damage, causing extreme pain and possibly death. Natural drugs such asAloe veraand vitamin E have been demonstrated to be beneficial in formulations for wound healing. The aim of this work is to develop and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6a83f6bc3526c88b8bb81250754b8a
https://doi.org/10.1155/2014/641590

Antidiuretic effect of desmopressin chimera agglomerates by nasal administration in rats

Autor: Paolo Colombo, Gaia Colombo, Anna Giulia Balducci, Fabrizio Bortolotti, Luca Ferraro, Fabio Sonvico, Paola Russo, Claudio Nastruzzi

Publikováno v: International Journal of Pharmaceutics. 440:154-160

In the present study, a nasal powder of the antidiuretic peptide desmopressin (DDAVP) formulated as chimera agglomerates was studied to improve drug bioavailability and provide a flexible drug product. Firstly, DDAVP was spray-dried along with mannit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac84a3152b91db6ba575b7ff40309c57
https://doi.org/10.1016/j.ijpharm.2012.09.049