Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Anna G, Sorace"'
Autor:
Yun Lu, Hailey A. Houson, Carlos A. Gallegos, Alessandro Mascioni, Fang Jia, Argin Aivazian, Patrick N. Song, Shannon E. Lynch, Tiara S. Napier, Ameer Mansur, Benjamin M. Larimer, Suzanne E. Lapi, Ariella B. Hanker, Anna G. Sorace
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Immune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the therapeutic response following immune checkpoint blockade (ICB) in immunologically “hot” tumors.
Externí odkaz:
https://doaj.org/article/a67333033d1f4caf9696ae27352ee60a
Autor:
Patrick N. Song, Shannon E. Lynch, Chloe T. DeMellier, Ameer Mansur, Carlos A. Gallegos, Brian D. Wright, Yolanda E. Hartman, Laura E. Minton, Suzanne E. Lapi, Jason M. Warram, Anna G. Sorace
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and hypoxia are associated with radioresistance. The goal of this study is to study the synergy of anti-HER2, trastuzumab, and anti-EGFR, cetuximab, an
Externí odkaz:
https://doaj.org/article/558a8968bead47b69cf936d5c973deaa
Autor:
Ernesto A. B. F. Lima, Patrick N. Song, Kirsten Reeves, Benjamin Larimer, Anna G. Sorace, Thomas E. Yankeelov
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 10, Pp 17625-17645 (2023)
The goal of this study is to develop a mathematical model that captures the interaction between evofosfamide, immunotherapy, and the hypoxic landscape of the tumor in the treatment of tumors. Recently, we showed that evofosfamide, a hypoxia-activated
Externí odkaz:
https://doaj.org/article/b4a6b342a4404b939a7de0f477b55c1f
Autor:
Ameer Mansur, Moozhan Nikpanah, Johnathan McConathy, Erica Stringer-Reasor, Gabrielle Rocque, Ahmed Elkhanany, Katia Khoury, Nusrat Jahan, Suzanne E. Lapi, Anna G. Sorace
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 139-139 (2024)
OBJECTIVES/GOALS: This study was performed to explore the capabilities of simultaneous [89 Zr]trastuzumab-PET/MRI acquisition in a cohort of metastatic HER2+ breast cancer. The insights derived provide additional noninvasive characterization and prec
Externí odkaz:
https://doaj.org/article/effaf72b545b453f872f48743d8b9f08
Autor:
John Virostko, Anna G. Sorace, Kalina P. Slavkova, Anum S. Kazerouni, Angela M. Jarrett, Julie C. DiCarlo, Stefanie Woodard, Sarah Avery, Boone Goodgame, Debra Patt, Thomas E. Yankeelov
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background The purpose of this study was to determine whether advanced quantitative magnetic resonance imaging (MRI) can be deployed outside of large, research-oriented academic hospitals and into community care settings to predict eventual
Externí odkaz:
https://doaj.org/article/82deaf63a0e6424a945d9c5d7d128036
Autor:
Ameer Mansur, Patrick N. Song, Yun Lu, Andrew C. Burns, Luke Sligh, Eddy S. Yang, Anna G. Sorace
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2090 (2023)
HER2–targeted treatments have improved survival rates in HER2+ breast cancer patients, yet poor responsiveness remains a major clinical obstacle. Recently, HER2+ breast cancer cells, both resistant and responsive to HER2–targeted therapies, have
Externí odkaz:
https://doaj.org/article/ef8d9b390bec44b383e87dcae87d5747
Autor:
Benjamin B. Kasten, Hailey A. Houson, Jennifer M. Coleman, Jianmei W. Leavenworth, James M. Markert, Anna M. Wu, Felix Salazar, Richard Tavaré, Adriana V. F. Massicano, G. Yancey Gillespie, Suzanne E. Lapi, Jason M. Warram, Anna G. Sorace
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Determination of treatment response to immunotherapy in glioblastoma multiforme (GBM) is a process which can take months. Detection of CD8+ T cell recruitment to the tumor with a noninvasive imaging modality such as positron emission tomogra
Externí odkaz:
https://doaj.org/article/5121b4300f984e959794f9b641be16e2
Autor:
Kalina P. Slavkova, Julie C. DiCarlo, Anum S. Kazerouni, John Virostko, Anna G. Sorace, Debra Patt, Boone Goodgame, Thomas E. Yankeelov
Publikováno v:
Tomography, Vol 7, Iss 3, Pp 253-267 (2021)
This study characterizes the error that results when performing quantitative analysis of abbreviated dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data of the breast with the Standard Kety–Tofts (SKT) model and its Patlak variant.
Externí odkaz:
https://doaj.org/article/244a6d56c90448bab12b3edcaba5617e
Autor:
Angela M. Jarrett, David A. Hormuth, II, Chengyue Wu, Anum S. Kazerouni, David A. Ekrut, John Virostko, Anna G. Sorace, Julie C. DiCarlo, Jeanne Kowalski, Debra Patt, Boone Goodgame, Sarah Avery, Thomas E. Yankeelov
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 820-830 (2020)
The ability to accurately predict response and then rigorously optimize a therapeutic regimen on a patient-specific basis, would transform oncology. Toward this end, we have developed an experimental-mathematical framework that integrates quantitativ
Externí odkaz:
https://doaj.org/article/17a79e5efe4e466a8d55e196250c77f9
Autor:
Patrick N. Song, Ameer Mansur, Kari J. Dugger, Tessa R. Davis, Grant Howard, Thomas E. Yankeelov, Anna G. Sorace
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Introduction The HER2 + tumor immune microenvironment is composed of macrophages, natural killer cells, and tumor infiltrating lymphocytes, which produce pro-inflammatory cytokines. Determining the effect of T-cells on HER2 + cancer cells du
Externí odkaz:
https://doaj.org/article/a6d9b0f27cef4b7493c859fe633a8349