Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Anna Fryszkowska"'
Autor:
John A. McIntosh, Tamas Benkovics, Steven M. Silverman, Mark A. Huffman, Jongrock Kong, Peter E. Maligres, Tetsuji Itoh, Hao Yang, Deeptak Verma, Weilan Pan, Hsing-I Ho, Jonathan Vroom, Anders M. Knight, Jessica A. Hurtak, Artis Klapars, Anna Fryszkowska, William J. Morris, Neil A. Strotman, Grant S. Murphy, Kevin M. Maloney, Patrick S. Fier
Publikováno v:
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
Externí odkaz:
https://doaj.org/article/0dca7a33b3304dad9cbbea813d344184
Autor:
Shaoguang Zhang, Anna Fryszkowska, Serge Ruccolo, Artis Klapars, Neil A. Strotman, Nicholas M. Marshall
Publikováno v:
ACS Catalysis. 11:7270-7280
Autor:
Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang, Wendy Zhong
Publikováno v:
Science (New York, N.Y.). 376(6599)
The emergence of new therapeutic modalities requires complementary tools for their efficient syntheses. Availability of methodologies for site-selective modification of biomolecules remains a long-standing challenge, given the inherent complexity and
Autor:
Aaron M. Whittaker, Serge Ruccolo, Artis Klapars, Sandra A. Robaire, Neil A. Strotman, Mark A. Huffman, Anna Fryszkowska, Shaoguang Zhang, Heather C. Johnson, Niki R. Patel
Publikováno v:
Organic & Biomolecular Chemistry. 19:1620-1625
Galactose oxidase (GOase) is a Cu-dependent metalloenzyme that catalyzes the oxidation of alcohols to aldehydes. An evolved GOase variant was recently shown to catalyze a desymmetrizing oxidation as the first enzymatic step in the biocatalytic synthe
Autor:
Edward C. Sherer, Junyong Jo, Holst M. Halsey, Jack Liang, Niki R. Patel, Agustina Rodriguez-Granillo, Christopher C. Nawrat, Aaron M. Whittaker, Canada Keith A, Margie Borra-Garske, Nicholas M. Marshall, Kevin R. Campos, Anna Fryszkowska, Yingju Xu, Paul N. Devine, Shane T. Grosser, Grant S. Murphy, Jovana Nazor, Matthew D. Truppo, Benjamin F. Mann, Jeffrey C. Moore, Sandra A. Robaire, Gregory Hughes, Scott J. Novick, Da Duan, Jacob Forstater, Joshua N. Kolev, Deeptak Verma, Kevin M. Maloney, Oscar Alvizo, Mark A. Huffman, Li Xiao, Mark McLaughlin, Leo A. Joyce, Hao Yang
Publikováno v:
Science. 366:1255-1259
Maximal efficiency from enzyme cascades Enzymes are highly selective catalysts that can be useful for specific transformations in organic synthesis. Huffman et al. combined designer enzymes in a multistep cascade reaction (see the Perspective by O'Re
Autor:
Jessica A. Hurtak, Steven M. Silverman, Kevin M. Maloney, Patrick S. Fier, Jonathan Vroom, Neil A. Strotman, Mark A. Huffman, Hao Yang, Peter E. Maligres, Tamas Benkovics, Anders M. Knight, Grant S. Murphy, Weilan Pan, Artis Klapars, Jongrock Kong, William J. Morris, John A. McIntosh, Tetsuji Itoh, Hsing-I Ho, Anna Fryszkowska, Deeptak Verma
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand and urgency for this compound, it was critical to develop a short and sustainable synthesis from sim
Autor:
Mark A. Huffman, Yingju Xu, Aaron M. Whittaker, Kevin M. Maloney, Teresa Andreani, David M. Tschaen, Andrew Brunskill, François Lévesque, Hongming Li, Christopher C. Nawrat, Mark McLaughlin, Hao Yang, Anna Fryszkowska, Niki R. Patel
Publikováno v:
Organic letters. 22(12)
The synthesis of the potent anti-HIV investigational treatment islatravir is described. The key step in this synthesis is a highly enantioselective catalytic asymmetric alkynylation of a ketone. This reaction is a rare example of the asymmetric addit
Autor:
Paul N. Devine, Anna Fryszkowska
Publikováno v:
Current opinion in chemical biology. 55
Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is beginning to transform chemical synthesis in the pharmaceutical industry. This review presents recent examples of the creative use of biocatalysis to enable drug
Publikováno v:
Tetrahedron: Asymmetry. 28:1127-1134
A novel asymmetric route to bicyclomycin analogues, 2-oxa-bicyclo[4.2.2]decane-8,10-diones, is described. The key chiral synthons 3-(ω-hydroxyalkyl)-2,5-diketopiperazines 3a-c were obtained via enzymatic kinetic resolution of their respective acetat