Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anna Frangou"'
Autor:
Richard Culliford, Samuel E. D. Lawrence, Charlie Mills, Zayd Tippu, Daniel Chubb, Alex J. Cornish, Lisa Browning, Ben Kinnersley, Robert Bentham, Amit Sud, Husayn Pallikonda, The Renal Cancer Genomics England Consortium, Anna Frangou, Andreas J. Gruber, Kevin Litchfield, David Wedge, James Larkin, Samra Turajlic, Richard S. Houlston
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking. We report the whole genome sequencing of 778 ccRCC patients enrolled in the 100,000 Genome
Externí odkaz:
https://doaj.org/article/25c1fd274e444b1a83a98b4d7c16c2c8
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256229 (2021)
Humans deploy a number of specific behaviours for forming social bonds, one of which is laughter. However, two questions have not yet been investigated with respect to laughter: (1) Does laughter increase the sense of bonding to those with whom we la
Externí odkaz:
https://doaj.org/article/9b101022c96f4abdb42503959b956979
Autor:
Claire Palles, Hannah D. West, Edward Chew, Sara Galavotti, Christoffer Flensburg, Judith E. Grolleman, Erik A.M. Jansen, Helen Curley, Laura Chegwidden, Edward H. Arbe-Barnes, Nicola Lander, Rebekah Truscott, Judith Pagan, Ashish Bajel, Kitty Sherwood, Lynn Martin, Huw Thomas, Demetra Georgiou, Florentia Fostira, Yael Goldberg, David J. Adams, Simone A.M. van der Biezen, Michael Christie, Mark Clendenning, Laura E. Thomas, Constantinos Deltas, Aleksandar J. Dimovski, Dagmara Dymerska, Jan Lubinski, Khalid Mahmood, Rachel S. van der Post, Mathijs Sanders, Jürgen Weitz, Jenny C. Taylor, Clare Turnbull, Lilian Vreede, Tom van Wezel, Celina Whalley, Claudia Arnedo-Pac, Giulio Caravagna, William Cross, Daniel Chubb, Anna Frangou, Andreas J. Gruber, Ben Kinnersley, Boris Noyvert, David Church, Trevor Graham, Richard Houlston, Nuria Lopez-Bigas, Andrea Sottoriva, David Wedge, Mark A. Jenkins, Roland P. Kuiper, Andrew W. Roberts, Jeremy P. Cheadle, Marjolijn J.L. Ligtenberg, Nicoline Hoogerbrugge, Viktor H. Koelzer, Andres Dacal Rivas, Ingrid M. Winship, Clara Ruiz Ponte, Daniel D. Buchanan, Derek G. Power, Andrew Green, Ian P.M. Tomlinson, Julian R. Sampson, Ian J. Majewski, Richarda M. de Voer
Publikováno v:
American Journal of Human Genetics, 109(5), 953-960. Cell Press
Palles, C, West, H, Chew, E, Galavotti, S, Flensburg, C, Grolleman, J, Jansen, E, Curley, H, Chedwiggen, L, Arbe-Barnes, E, Lander, N, Truscot, R, Pagan, J, Bajel, A, Sherwood, K, Martin, L, Thomas, H, Georgiou, D, Fostira, F, Goldberg, Y, Adams, D, van der Biezen, S, Christie, M, Clendenning, M, Thomas, L, Deltas, C, Dimovski, A, Dymerska, D, Lubinski, J, Mahmood, K, van der Post, R, Sanders, M, Weitz, J, Taylor, J, Turnbull, C, Vreede, L, van Wezel, T, Whalley, C, Arnedo, C, Caravagna, G, Cross, W, Chubb, D, Frangou, A, Gruber, A, Kinnersley, B, Noyvert, B, Church, D, Graham, T, Houlston, R, Lopez, N, Sottoriva, A, Wedge, D, Jenkins, M, Kuiper, R, Roberts, A, Cheadle, J, Ligtenberg, M, Hoogerbrugge, N, Koelzer, V, Dacal Rivas, A, Winship, I, Ruiz Ponte, C, Buchanan, D, Power, D, Green, A, Tomlinson, I P M, Sampson, J, Majewski, I & M. de Voer, R 2022, ' Germline MBD4-deficiency causes a multi-tumor predisposition syndrome ', American Journal of Human Genetics, vol. 109, no. 5, pp. 953-960 . https://doi.org/10.1016/j.ajhg.2022.03.018
American Journal of Human Genetics, 109, 953-960
American Journal of Human Genetics, 109, 5, pp. 953-960
Palles, C, West, H, Chew, E, Galavotti, S, Flensburg, C, Grolleman, J, Jansen, E, Curley, H, Chedwiggen, L, Arbe-Barnes, E, Lander, N, Truscot, R, Pagan, J, Bajel, A, Sherwood, K, Martin, L, Thomas, H, Georgiou, D, Fostira, F, Goldberg, Y, Adams, D, van der Biezen, S, Christie, M, Clendenning, M, Thomas, L, Deltas, C, Dimovski, A, Dymerska, D, Lubinski, J, Mahmood, K, van der Post, R, Sanders, M, Weitz, J, Taylor, J, Turnbull, C, Vreede, L, van Wezel, T, Whalley, C, Arnedo, C, Caravagna, G, Cross, W, Chubb, D, Frangou, A, Gruber, A, Kinnersley, B, Noyvert, B, Church, D, Graham, T, Houlston, R, Lopez, N, Sottoriva, A, Wedge, D, Jenkins, M, Kuiper, R, Roberts, A, Cheadle, J, Ligtenberg, M, Hoogerbrugge, N, Koelzer, V, Dacal Rivas, A, Winship, I, Ruiz Ponte, C, Buchanan, D, Power, D, Green, A, Tomlinson, I P M, Sampson, J, Majewski, I & M. de Voer, R 2022, ' Germline MBD4-deficiency causes a multi-tumor predisposition syndrome ', American Journal of Human Genetics, vol. 109, no. 5, pp. 953-960 . https://doi.org/10.1016/j.ajhg.2022.03.018
American Journal of Human Genetics, 109, 953-960
American Journal of Human Genetics, 109, 5, pp. 953-960
Contains fulltext : 251996.pdf (Publisher’s version ) (Open Access) We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision repair (BER) gene MBD4. We
Autor:
Annalise Katz-Summercorn, Iliana Peneva, Anna Frangou, Sriganesh Jammula, Maria O'Donovan, Monika Tripathi, Shalini Malhotra, Massimiliano di Pietro, Ginny Devonshire, Aisling Redmond, David Wedge, Rebecca Fitzgerald
Publikováno v:
British Journal of Surgery. 109
Background Intra-tumour heterogeneity has been well-described in oesophageal adenocarcinoma and Barrett's oesophagus (BE) segments also consist of multiple clones (groups of cells which share mutations). In BE there is some suggestion that the number
Autor:
Ian Tomlinson, Alex Cornish, Andreas Gruber, Richard Houlston, Amit Sud, Philip Law, Eszter Lakatos, Richard Culliford, Jacob Househam, Trevor Graham, Henry Wood, Philip Quirke, Nuria Lopez-Bigas, Claudia Arnedo-Pac, Daniel Chubb, Maire Ni Leathlobhair, Boris Noyvert, Ben Kinnersley, William Cross, Nirupa Murugaesu, Alona Sosinsky, Jonathan Mitchell, Ludmil Alexandrov, Luis Zapata, Juan Fernandez-Tajes, Steve Thorn, Kitty Sherwood, Guler Gul, Aliah Hawari, Andrea Sottoriva, David Church, Giulio Caravagna, David Wedge, Anna Frangou
To characterise the somatic alterations in colorectal cancer (CRC), we conducted whole-genome sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution map to date of somatic mutations in CRC, and demonstrate associations wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d667ff9c3f5ecfc24c3d589c03f2d1a
https://doi.org/10.21203/rs.3.rs-2273265/v1
https://doi.org/10.21203/rs.3.rs-2273265/v1
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256229 (2021)
PLoS ONE
PLoS ONE
Humans deploy a number of specific behaviours for forming social bonds, one of which is laughter. However, two questions have not yet been investigated with respect to laughter: (1) Does laughter increase the sense of bonding to those with whom we la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b52ade7393e541e2d630deb6583e8e
https://doi.org/10.1371/journal.pone.0256229
https://doi.org/10.1371/journal.pone.0256229
Autor:
Persephone Borrow, Hayato Murakoshi, Nicola Ternette, Andrew G. Smith, Thomas Partridge, Annalisa Nicastri, Anna Frangou, Shinichi Oka, Robert Parker, Wayne Paes, German Leonov, Takayuki Chikata, Ian Williams, Beatrice H. Hahn, Masafumi Takiguchi, Andrew J. McMichael, Barton F. Haynes, Gerald H. Learn, Pierre Pellegrino, Simon Brackenridge, Yingying Li, George M. Shaw
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance CD8+ T cells target virus-infected and tumor cells by recognition of peptides presented on human leukocyte antigen (HLA)-I molecules. Many of these peptides are generated by proteasome-mediated protein degradation. Proteasomes can also
Autor:
Annalise Katz-Summercorn, Sriganesh Jammula, Anna Frangou, Iliana Peneva, Maria O'Donovan, Monika Tripathi, Shalini Malhotra, Massimiliano di Pietro, Shujath Abbas, Ginny Devonshire, Wladyslaw Januszewicz, Adrienn Blasko, Karol Nowicki-Osuch, Shona MacRae, Alex Northrop, Aisling Redmond, David Wedge, Rebecca Fitzgerald
Publikováno v:
British Journal of Surgery. 108
Background Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma (OAC), yet few patients ever go on to progress to cancer. The acquisition of events during the metaplasia-dysplasia-cancer sequence is po
Autor:
Thomas M. Carroll, Joseph A. Chadwick, Richard P. Owen, Michael J. White, Joseph Kaplinsky, Iliana Peneva, Anna Frangou, Jaeho Chang, Phil F. Xie, Andrew Roth, Bob Amess, Hantao Lou, Katy J. McCann, Georgina Berridge, Roman Fischer, Chansavath Phetsouphanh, Ayo O. Omiyale, Brittany-Amber Jacobs, David Ahern, Simon R. Lord, Stewart Norris-Bulpitt, Sam T. Dobbie, Lucinda Griffiths, Kristen Aufiero Ramirez, Toni Ricciardi, Mary J. Macri, Aileen Ryan, Ralph R. Venhaus, Benoit J. Van den Eynde, Ioannis Karydis, Benedikt M. Kessler, Benjamin Schuster-Böckler, Mark R. Middleton, Xin Lu
Publikováno v:
Cancer Research. 82:1247-1247
For patients with inoperable esophageal adenocarcinoma (EAC), prognosis on conventional chemotherapy (CTX) remains poor. In 2021, the FDA approved two αPD-1 immune checkpoint inhibitors (ICI) for addition to fluoropyrimidine/platinum-containing CTX
Autor:
Khalid Mahmood, Chew E, Dagmara Dymerska, Roberts Aw, Mark Clendenning, Christoffer Flensburg, Nicoline Hoogerbrugge, Ben Kinnersley, Goldberg Y, Boris Noyvert, Jenny C. Taylor, Mathijs A. Sanders, van Wezel T, Lilian Vreede, Giulio Caravagna, Daniel D. Buchanan, Curley H, van der Biezen Sa, Richard S. Houlston, Celina Whalley, Michael Christie, Laura Chegwidden, Georgiou D, Judith E. Grolleman, Huw Thomas, Galavotti S, Sherwood K, Sottoriva A, Erik A. M. Jansen, Aleksandar Dimovski, Mark A. Jenkins, M.J.L. Ligtenberg, Roland P. Kuiper, Ian J. Majewski, Bajel A, Jakub Lubiński, Ian Tomlinson, Anna Frangou, Claire Palles, Pac Ca, Florentia Fostira, Deltas C, Clare Turnbull, Ingrid Winship, David N. Church, Lynn Martin, William Cross, Jürgen Weitz, David C. Wedge, Koelzer Vh, Rivas Ad, Barnes Ea, Nuria Lopez-Bigas, David J. Adams, van der Post Rs, Daniel Chubb, de Voer Rm, Trevor A. Graham, Andreas J. Gruber, Ponte Cr
Inherited defects in base-excision repair (BER) predispose to adenomatous polyposis and colorectal cancer (CRC), yet our understanding of this important DNA repair pathway remains incomplete. By combining detailed clinical, histological and molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0577ac58ac91b90d3d096b44b8aabcf
https://doi.org/10.1101/2021.04.27.441137
https://doi.org/10.1101/2021.04.27.441137