A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.

Autor: David Lutje Hulsik, Ying-ying Liu, Nika M Strokappe, Simone Battella, Mohamed El Khattabi, Laura E McCoy, Charles Sabin, Andreas Hinz, Miriam Hock, Pauline Macheboeuf, Alexandre M J J Bonvin, Johannes P M Langedijk, David Davis, Anna Forsman Quigley, Marlén M I Aasa-Chapman, Michael S Seaman, Alejandra Ramos, Pascal Poignard, Adrien Favier, Jean-Pierre Simorre, Robin A Weiss, C Theo Verrips, Winfried Weissenhorn, Lucy Rutten

Publikováno v: PLoS Pathogens, Vol 9, Iss 3, p e1003202 (2013)

The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodie

Externí odkaz: https://doaj.org/article/bedacc53dae644739bdc70b2ea981c66

Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site

Autor: Tongqing Zhou, Lei Chen, Jason Gorman, Shuishu Wang, Young D. Kwon, Bob C. Lin, Mark K. Louder, Reda Rawi, Erik-Stephane D. Stancofski, Yongping Yang, Baoshan Zhang, Anna Forsman Quigley, Laura E. McCoy, Lucy Rutten, Theo Verrips, Robin A. Weiss, Nicole A. Doria-Rose, Lawrence Shapiro, Peter D. Kwong

Publikováno v: Structure. 30:862-875.e4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19bbf7830eac3eb50289f37ac9fe1b78
https://doi.org/10.1016/j.str.2022.03.012

Llama Antibody Fragments Have Good Potential for Application as HIV Type 1 Topical Microbicides

Autor: Andrea Gorlani, H. De Haard, P. van der Bijl, Karl Malcolm, Joachim Brouwers, Theo Verrips, Christopher F McConville, Anna Forsman Quigley, Robin A. Weiss, Patrick Augustijns

Publikováno v: AIDS Research and Human Retroviruses. 28:198-205

There is an urgent global need for preventive strategies against HIV-1 infections. Llama heavy-chain antibody fragments (VHH) are a class of molecules recently described as potent cross-clade HIV-1 entry inhibitors. We studied the potential of a VHH-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf9a569637e729d9965cbadad291124
https://doi.org/10.1089/aid.2011.0133

Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C

Autor: Andrea Gorlani, David Lutje Hulsik, Anna Forsman Quigley, Lei Chen, Agnieszka Szynol, Marlén M. I. Aasa-Chapman, Nika M. Strokappe, Robin A. Weiss, Hans de Haard, Theo Verrips

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33298 (2012)
PloS one, vol 7, iss 3
PLoS ONE

Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an important target for antibody-based therapy. Variable doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf42588a745fedf0732b00df6b1433ca
http://europepmc.org/articles/PMC3305327?pdf=render

A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

Autor: Laura E. McCoy, Simone Battella, Charles Sabin, Alexandre M. J. J. Bonvin, Andreas Hinz, Robin A. Weiss, Michael S. Seaman, David Lutje Hulsik, Lucy Rutten, Miriam Hock, C. Theo Verrips, Alejandra Ramos, Winfried Weissenhorn, Nika M. Strokappe, Pauline Macheboeuf, Johannes P. M. Langedijk, Mohamed El Khattabi, Adrien Favier, Pascal Poignard, Ying-ying Liu, David Davis, Marlén M. I. Aasa-Chapman, Jean-Pierre Simorre, Anna Forsman Quigley

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2013, 9 (3), pp.e1003202. ⟨10.1371/journal.ppat.1003202⟩
PLoS Pathogens, Vol 9, Iss 3, p e1003202 (2013)
PLoS Pathogens, Public Library of Science, 2013, 9 (3), pp.e1003202. ⟨10.1371/journal.ppat.1003202⟩
PLoS Pathogens, 9(3), 1. Public Library of Science
'PLoS Pathogens ', vol: 9, pages: e1003202-1-e1003202-16 (2013)

The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5c6dd9dabec61231951a4a657160d3
https://doi.org/10.1371/journal.ppat.1003202