Assessing the Neurodevelopmental Impact of Fluoxetine, Citalopram, and Paroxetine on Neural Stem Cell-Derived Neurons

Autor: Kimia Hosseini, Andrea Cediel-Ulloa, Mohamed H. AL-Sabri, Anna Forsby, Robert Fredriksson

Publikováno v: Pharmaceuticals, Vol 17, Iss 10, p 1392 (2024)

Background/Objectives: Many pregnant women globally suffer from depression and are routinely prescribed selective serotonin reuptake inhibitors (SSRIs). These drugs function by blocking the re-uptake of serotonin by the serotonin transporter (SERT) i

Externí odkaz: https://doaj.org/article/28e518c6a79a4335a483e26fd54245ba

Whole genome microarray analysis of neural progenitor C17.2 cells during differentiation and validation of 30 neural mRNA biomarkers for estimation of developmental neurotoxicity.

Autor: Kristina Attoff, Anda Gliga, Jessica Lundqvist, Ulf Norinder, Anna Forsby

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0190066 (2017)

Despite its high relevance, developmental neurotoxicity (DNT) is one of the least studied forms of toxicity. Current guidelines for DNT testing are based on in vivo testing and they require extensive resources. Transcriptomic approaches using relevan

Externí odkaz: https://doaj.org/article/09e564ab65294e28a07fa117e17c430d

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autor: Paul Jennings, Giada Carta, Johannes P Schimming, Erik H.J. Danen, Marcel Leist, Giulia Callegaro, Nanette G Vrijenhoek, Joost B. Beltman, Anna Forsby, Johannes Delp, Andrew White, Bob van de Water, Sylvia E. Le Dévédec, Huan Yang, Wanda van der Stel, Salihanur Darici

Publikováno v: van der Stel, W, Yang, H, Vrijenhoek, N G, Schimming, J P, Callegaro, G, Carta, G, Darici, S, Delp, J, Forsby, A, White, A, le Dévédec, S, Leist, M, Jennings, P, Beltman, J B, van de Water, B & Danen, E H J 2022, ' Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation ', Archives of Toxicology, vol. 96, no. 1, pp. 259-285 . https://doi.org/10.1007/s00204-021-03160-7
Archives of Toxicology, 96
Archives of Toxicology
Archives of Toxicology, 96(1), 259-285. Springer Verlag

Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron transport chain (ETC) complex I, II, or III (CI, CII and CIII) inhibitors affect mitochondrial functionality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e5ec3b4fb4c6608dfe265e2934a630
https://hdl.handle.net/1871.1/e0b19077-5a27-48fb-bc1b-0dc3bbb415f8

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

Autor: Dominik Loser, Timm Danker, Clemens Möller, Markus Brüll, Jonathan Blum, Anna Forsby, Maria G. Hinojosa, Ylva Johansson, Udo Kraushaar, Ilinca Suciu, Iain Gardner, Gerhard F. Ecker, Karin Grillberger, Jasmin Schaefer, Marcel Leist, Susanne Hougaard Bennekou

Publikováno v: Loser, D, Hinojosa, M G, Blum, J, Schaefer, J, Brüll, M, Johansson, Y, Suciu, I, Grillberger, K, Danker, T, Möller, C, Gardner, I, Ecker, G F, Bennekou, S H, Forsby, A, Kraushaar, U & Leist, M 2021, ' Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons ', Archives of Toxicology, vol. 95, pp. 2081–2107 . https://doi.org/10.1007/s00204-021-03031-1
Archives of Toxicology

Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637d24dda1e3a374f3fd40abcf58d2b1
https://orbit.dtu.dk/en/publications/fb84aa7a-e600-436e-b76d-3a0e4345e020

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

Autor: Anna Forsby, Iain Gardner, Erik H.J. Danen, Paul Jennings, Julie Eakins, Susanne Hougaard Bennekou, Marcel Leist, Wanda van der Stel, Salihanur Darici, Giada Carta, Johannes Delp, Bob van de Water, Paul Walker

Publikováno v: Arch Toxicol
van der Stel, W, Carta, G, Eakins, J, Darici, S, Delp, J, Forsby, A, Bennekou, S H, Gardner, I, Leist, M, Danen, E H J, Walker, P, van de Water, B & Jennings, P 2020, ' Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals ', Archives of Toxicology, vol. 94, pp. 2707–2729 . https://doi.org/10.1007/s00204-020-02792-5
Archives of Toxicology
van der Stel, W, Carta, G, Eakins, J, Darici, S, Delp, J, Forsby, A, Bennekou, S H, Gardner, I, Leist, M, Danen, E H J, Walker, P, van de Water, B & Jennings, P 2020, ' Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals ', Archives of Toxicology, vol. 94, no. 8, pp. 2707-2729 . https://doi.org/10.1007/s00204-020-02792-5
Archives of Toxicology, 94(8), 2707-2729
Archives of Toxicology, 94(8), 2707-2729. Springer Verlag

Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies including metabolic diseases, accelerated ageing, neurodegenerative diseases and in certain xenobiotic-induced organ toxicity. Assessing mitochondrial pertu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c62e4a962eeafee36938d0bc3f7c14
https://doi.org/10.1007/s00204-020-02792-5