The oral ferroportin inhibitor vamifeport prevents liver iron overload in a mouse model of hemochromatosis

Autor: Naja Nyffenegger, Anna Flace, Ahmet Varol, Patrick Altermatt, Cédric Doucerain, Hanna Sundstrom, Franz Dürrenberger, Vania Manolova

Publikováno v: HemaSphere, Vol 8, Iss 9, Pp n/a-n/a (2024)

Abstract Hemochromatosis is an inherited iron overload condition caused by mutations that reduce the levels of the iron‐regulatory hormone hepcidin or its binding to ferroportin. The hepcidin–ferroportin axis is pivotal to iron homeostasis, provi

Externí odkaz: https://doaj.org/article/6275d404ed394da882c80dfa9aa97074

The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia

Autor: Cédric Doucerain, Anna Flace, Vania Manolova, Naja Nyffenegger, Franz Dürrenberger

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 873, p 873 (2021)

In &beta
thalassemia, ineffective erythropoiesis leads to anemia and systemic iron overload. The management of iron overload by chelation therapy is a standard of care. However, iron chelation does not improve the ineffective erythropoiesis. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee67481c66a7139c37bc0807a905c8e

Adjusted particle size eliminates the need of linkage of antigen and adjuvants for appropriated T cell responses in virus-like particle-based vaccines

Autor: Vania Manolova, Ariane C Gomes, Franziska Zabel, Aadil El Turabi, Philippe Saudan, Anna Flace, Martin F. Bachmann, Gustavo Cabral-Miranda

Publikováno v: Frontiers in Immunology
Gomes, Ariane C; Flace, Anna; Saudan, Philippe; Zabel, Franziska; Cabral-Miranda, Gustavo; Turabi, Aadil El; Manolova, Vania; Bachmann, Martin (2017). Adjusted Particle Size Eliminates the Need of Linkage of Antigen and Adjuvants for Appropriated T Cell Responses in Virus-Like Particle-Based Vaccines. Frontiers in immunology, 8, p. 226. Frontiers Research Foundation 10.3389/fimmu.2017.00226

Since the discovery of the first VLP derived from Hepatitis B virus in 19801, the field has expanded substantially. Besides successful use of VLPs as safe autologous virus-targeting vaccines, the powerful immunogenicity of VLPs has been also harnesse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cb0296bfd6af2e6d996c4969170236
https://ora.ox.ac.uk/objects/uuid:24f8ff88-07d4-4f1a-89fd-4f4965368f16

Nanoparticles target distinct dendritic cell populations according to their size

Autor: Katrin Schwarz, Vania Manolova, Monika Bauer, Martin F. Bachmann, Anna Flace, Philippe Saudan

Publikováno v: European Journal of Immunology. 38:1404-1413

The efficiency of a vaccine largely depends on the appropriate targeting of the innate immune system, mainly through prolonged delivery of antigens and immunomodulatory substances to professional antigen-presenting cells in the lymphoid environment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daebe86dfdd4e4324eed61528140708e
https://doi.org/10.1002/eji.200737984

Cover Picture: Nanoparticles target distinct dendritic cell populations according to their size – Eur. J. Immunol. 5/2008

Autor: Anna Flace, Philippe Saudan, Katrin Schwarz, Monika Bauer, Martin F. Bachmann, Vania Manolova

Publikováno v: European Journal of Immunology. 38

The cover shows a colour series of mouse footpads injected with small fluorescent nanoparticles. The image depicts the afferent lymphatic vessels connecting the injection site with the draining popliteal lymph node and the more distal sciatic lymph n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::048aa4ba62a8bf18d50257b8514b05ba
https://doi.org/10.1002/eji.200890018